DegronMD

Uniprot ID: A8MU46

Source protein: Smoothelin-like protein 1

Source gene: SMTNL1

Class: DEG_Kelch_Keap1_1

Location: 320:325

E3 ligase: KEAP1

DEGRON score: 0.8915

ASA_SCORE: 80.6333

COIL: 0.9085

CONS_SCORE: 0.5115

DSS_SCORE: 0.8419

HELIX: 0.0657

FCONS_SCORE: 0.9333

RIG_SCORE: 0.4314

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D312G	DO229010	COCA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.1111
p.D312Y	DO228948	LICA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.1111
p.S334I	DO228952	LICA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.0833
p.G317E	DO222402	MELA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.25
p.P328H	DO229229	THCA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.25
p.G324A	SIDM00947	Glioblastoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.754
p.G324A	ACH-000244	Brain Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.754
p.G324A	DK-MG	central_nervous_system	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	0.754
p.P318S	SIDM00628	Breast Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.P318S	ACH-000849	Breast Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.P318S	MDA-MB-468	breast	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.R312H	ACH-000986	Colon/Colorectal Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.1111
p.R312H	HT-115	large_intestine	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	0.1111
p.V335I	ACH-001991	Primary	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.0556
p.R331H	IGROV-1	ovary	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	0.1667
p.V316M	TOV-21G	ovary	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	0.2222
p.T327M	EFO-27	ovary	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MU46	Smoothelin-like protein 1	DEG_Kelch_Keap1_1	320:325	SPSSGE	KEAP1	0.8915	More...
O15457	MutS protein homolog 4	DEG_Kelch_Keap1_1	17:22	SPSSGE	KEAP1	0.9846	More...
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_Kelch_Keap1_1	451:456	SPSSGE	KEAP1	0.9304	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_Kelch_Keap1_1	717:722	SPSSGE	KEAP1	0.9938	More...
Q9UIF9	Bromodomain adjacent to zinc finger domain protein 2A	DEG_Kelch_Keap1_1	26:31	SPSSGE	KEAP1	0.9651	More...
Q6ZV50	DNA-binding protein RFX8	DEG_Kelch_Keap1_1	8:13	SPSSGE	KEAP1	0.8762	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons