DegronMD - O15457(MSH4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R129G	TCGA-13-0764	OV	TCGA	LKTPLST	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.1944
p.R129G	DO30930	OV	ICGC	LKTPLST	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.1944
p.Q27H	TCGA-39-5040	LUSC	TCGA	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.1944
p.Q27H	TCGA-CV-6933	HNSC	TCGA	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.1944
p.Q27H	DO14164	HNSC	ICGC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.1944
p.Q27H	DO45436	LUSC	ICGC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.1944
p.Q27H	SIDM00789	Colorectal Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.1944
p.Q27H	ACH-000997	Colon/Colorectal Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.1944
p.Q27H	ACH-001061	Colon/Colorectal Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.1944
p.Q27H	HCT-15	large intestine	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.1944
p.S20W	TCGA-55-1595	LUAD	TCGA	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation altering degron motif	0.7874
p.S20W	DO23558	LUAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation altering degron motif	0.7874
p.S12C	TCGA-62-8399	LUAD	TCGA	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.1944
p.S12C	DO24606	LUAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.1944
p.R30H	TCGA-AA-3663	COAD	TCGA	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.1111
p.R30H	DO9346	COAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.1111
p.A15V	TCGA-AX-A2HD	UCEC	TCGA	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.2778
p.A15V	DO42608	UCEC	ICGC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.2778
p.A15V	ACH-001842	Bile Duct Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.2778
p.A15V	ACH-001991	Primary	CCLE	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.2778
p.D111Y	TCGA-BS-A0UF	UCEC	TCGA	LKTPLST	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.1389
p.D111Y	DO41488	UCEC	ICGC	LKTPLST	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.1389
p.S12T	TCGA-CI-6624	READ	TCGA	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.1944
p.S12T	DO37130	READ	ICGC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.1944
p.P14L	TCGA-EE-A29V	SKCM	TCGA	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.25
p.P14L	DO38006	SKCM	ICGC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.25
p.P29S	TCGA-GN-A4U8	SKCM	TCGA	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.1389
p.P29S	DO47320	SKCM	ICGC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.1389
p.S20L	TCGA-IB-7651	PAAD	TCGA	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation altering degron motif	0.7667
p.S20L	DO46657	PAAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation altering degron motif	0.7667
p.D111N	TCGA-IZ-8196	KIRP	TCGA	LKTPLST	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.1389
p.D111N	DO44461	KIRP	ICGC	LKTPLST	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.1389
p.R24L	TCGA-MN-A4N4	LUAD	TCGA	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.2778
p.R24L	DO229029	LICA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.2778
p.R24L	DO26250	LUAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.2778
p.A109T	DO222769	COCA	ICGC	LKTPLST	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.0833
p.R30C	DO233942	GACA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.1111
p.P18S	DO222868	MELA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation altering degron motif	0.5641
p.P121L	DO218898	SKCA	ICGC	LKTPLST	DEG_SCF_FBW7_1	118:124	Mutation altering degron motif	0.7582
p.P127L	SIDM00545	Melanoma	GDSC	LKTPLST	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.25
p.P127L	ACH-000987	Skin Cancer	CCLE	LKTPLST	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.25
p.P127L	Mewo	skin	COSMIC	LKTPLST	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.25
p.S17F	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation altering degron motif	0.7982
p.S17F	ACH-000694	Esophageal Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation altering degron motif	0.7982
p.S17F	TE-9	oesophagus	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation altering degron motif	0.7982
p.S7P	SIDM01617	Endometrial Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.0556
p.S7P	ACH-000994	Endometrial/Uterine Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.0556
p.V16A	ACH-001669	Leukemia	CCLE	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.3056
p.V16A	ACH-002238	Leukemia	CCLE	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.3056
p.V16A	GR-ST	haematopoietic and lymphoid tissue	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MSH4

UniProt ID: O15457

Entrez ID: 4438

Protein name: MutS protein homolog 4 (hMSH4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MSH4 in