DegronMD

Uniprot ID: O15457

Source protein: MutS protein homolog 4

Source gene: MSH4

Class: DEG_Kelch_Keap1_1

Location: 17:22

E3 ligase: KEAP1

DEGRON score: 0.9846

ASA_SCORE: 80.1333

COIL: 0.9208

CONS_SCORE: 0.2729

DSS_SCORE: 0.7648

HELIX: 0.0357

FCONS_SCORE: 1.0299

RIG_SCORE: 0.4967

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q27H	TCGA-39-5040	LUSC	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.1944
p.Q27H	TCGA-CV-6933	HNSC	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.1944
p.Q27H	DO14164	HNSC	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.1944
p.Q27H	DO45436	LUSC	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.1944
p.Q27H	SIDM00789	Colorectal Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.1944
p.Q27H	ACH-000997	Colon/Colorectal Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.1944
p.Q27H	ACH-001061	Colon/Colorectal Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.1944
p.Q27H	HCT-15	large_intestine	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	0.1944
p.S20W	TCGA-55-1595	LUAD	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.7874
p.S20W	DO23558	LUAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.7874
p.S12C	TCGA-62-8399	LUAD	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.1944
p.S12C	DO24606	LUAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.1944
p.R30H	TCGA-AA-3663	COAD	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.1111
p.R30H	DO9346	COAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.1111
p.A15V	TCGA-AX-A2HD	UCEC	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.A15V	DO42608	UCEC	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.A15V	ACH-001842	Bile Duct Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.A15V	ACH-001991	Primary	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.S12T	TCGA-CI-6624	READ	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.1944
p.S12T	DO37130	READ	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.1944
p.P14L	TCGA-EE-A29V	SKCM	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.25
p.P14L	DO38006	SKCM	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.25
p.P29S	TCGA-GN-A4U8	SKCM	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.1389
p.P29S	DO47320	SKCM	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.1389
p.S20L	TCGA-IB-7651	PAAD	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.7667
p.S20L	DO46657	PAAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.7667
p.R24L	TCGA-MN-A4N4	LUAD	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.R24L	DO229029	LICA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.R24L	DO26250	LUAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.R30C	DO233942	GACA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.1111
p.P18S	DO222868	MELA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.5641
p.S17F	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.7982
p.S17F	ACH-000694	Esophageal Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.7982
p.S17F	TE-9	oesophagus	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	0.7982
p.S7P	SIDM01617	Endometrial Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.0556
p.S7P	ACH-000994	Endometrial/Uterine Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.0556
p.V16A	ACH-001669	Leukemia	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.3056
p.V16A	ACH-002238	Leukemia	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.3056
p.V16A	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MU46	Smoothelin-like protein 1	DEG_Kelch_Keap1_1	320:325	SPSSGE	KEAP1	0.8915	More...
O15457	MutS protein homolog 4	DEG_Kelch_Keap1_1	17:22	SPSSGE	KEAP1	0.9846	More...
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_Kelch_Keap1_1	451:456	SPSSGE	KEAP1	0.9304	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_Kelch_Keap1_1	717:722	SPSSGE	KEAP1	0.9938	More...
Q9UIF9	Bromodomain adjacent to zinc finger domain protein 2A	DEG_Kelch_Keap1_1	26:31	SPSSGE	KEAP1	0.9651	More...
Q6ZV50	DNA-binding protein RFX8	DEG_Kelch_Keap1_1	8:13	SPSSGE	KEAP1	0.8762	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SPSSGE

Degron related mutations and impact score

Drug responses associated with MSH4 mutations

All proteins holding degron of SPSSGE