DegronMD

Uniprot ID: Q6ZV50

Source protein: DNA-binding protein RFX8

Source gene: RFX8

Class: DEG_Kelch_Keap1_1

Location: 8:13

E3 ligase: KEAP1

DEGRON score: 0.8762

ASA_SCORE: 80.8333

COIL: 0.9332

CONS_SCORE: 0.3578

DSS_SCORE: 0.6504

HELIX: 0.046

FCONS_SCORE: 0.7587

RIG_SCORE: 0.5439

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E7D	TCGA-F5-6814	READ	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.3056
p.E7D	DO36556	READ	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.3056
p.V6M	DO222782	COCA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.S20R	DO229036	LICA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.1389
p.A2T	DO38404	STAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.1667
p.V6L	SIDM00120	Prostate Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.V6L	DU-145	prostate	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.T8N	SIDM00731	Small Cell Lung Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.7055
p.T8N	NCI-H2196	lung	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	0.7055
p.P19L	SIDM00849	Kidney Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.1667
p.P19L	SIDM00672	Hepatocellular Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.1667
p.P19L	SIDM00793	Burkitt's Lymphoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.1667
p.P19L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.1667
p.P19L	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.1667
p.P18L	ACH-000670	Lung Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MU46	Smoothelin-like protein 1	DEG_Kelch_Keap1_1	320:325	SPSSGE	KEAP1	0.8915	More...
O15457	MutS protein homolog 4	DEG_Kelch_Keap1_1	17:22	SPSSGE	KEAP1	0.9846	More...
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_Kelch_Keap1_1	451:456	SPSSGE	KEAP1	0.9304	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_Kelch_Keap1_1	717:722	SPSSGE	KEAP1	0.9938	More...
Q9UIF9	Bromodomain adjacent to zinc finger domain protein 2A	DEG_Kelch_Keap1_1	26:31	SPSSGE	KEAP1	0.9651	More...
Q6ZV50	DNA-binding protein RFX8	DEG_Kelch_Keap1_1	8:13	SPSSGE	KEAP1	0.8762	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons