DegronMD

Uniprot ID: Q6WKZ4

Source protein: Rab11 family-interacting protein 1

Source gene: RAB11FIP1

Class: DEG_Kelch_Keap1_1

Location: 717:722

E3 ligase: KEAP1

DEGRON score: 0.9938

ASA_SCORE: 74.85

COIL: 0.8425

CONS_SCORE: 0.2798

DSS_SCORE: 0.5663

HELIX: 0.1352

FCONS_SCORE: 1.0668

RIG_SCORE: 0.599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P727S	TCGA-2W-A8YY	CESC	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.1944
p.P727S	DO223732	CESC	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.1944
p.Q714L	TCGA-86-A4JF	LUAD	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.25
p.Q714L	DO45317	LUAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.25
p.P707Q	TCGA-ER-A2NH	SKCM	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.0556
p.P707Q	DO47683	SKCM	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.0556
p.Q724K	DO228974	LICA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.L730I	DO229026	LICA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.1111
p.P710S	DO27943	ORCA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.1389
p.P707L	DO33128	PACA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.0556
p.P707L	SIDM00210	Ovarian Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MU46	Smoothelin-like protein 1	DEG_Kelch_Keap1_1	320:325	SPSSGE	KEAP1	0.8915	More...
O15457	MutS protein homolog 4	DEG_Kelch_Keap1_1	17:22	SPSSGE	KEAP1	0.9846	More...
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_Kelch_Keap1_1	451:456	SPSSGE	KEAP1	0.9304	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_Kelch_Keap1_1	717:722	SPSSGE	KEAP1	0.9938	More...
Q9UIF9	Bromodomain adjacent to zinc finger domain protein 2A	DEG_Kelch_Keap1_1	26:31	SPSSGE	KEAP1	0.9651	More...
Q6ZV50	DNA-binding protein RFX8	DEG_Kelch_Keap1_1	8:13	SPSSGE	KEAP1	0.8762	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons