DegronMD - O60292(SIPA1L3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y824D	TCGA-12-0778	GBM	TCGA	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.0833
p.Y824D	DO11411	GBM	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.0833
p.R1123W	TCGA-16-0848	GBM	TCGA	IVPFRE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.7523
p.R1123W	DO12196	GBM	ICGC	IVPFRE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.7523
p.T836N	TCGA-22-4595	LUSC	TCGA	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation altering degron motif	0.7055
p.T836N	DO26641	LUSC	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation altering degron motif	0.7055
p.T1703I	TCGA-2W-A8YY	CESC	TCGA	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation altering degron motif	0.8189
p.T1703I	DO223732	CESC	ICGC	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation altering degron motif	0.8189
p.P452L	TCGA-32-2616	GBM	TCGA	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation altering degron motif	0.6471
p.P452L	DO13462	GBM	ICGC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation altering degron motif	0.6471
p.T1053S	TCGA-4A-A93W	KIRP	TCGA	IPPFED	LIG_APCC_ABBA_1	1038:1043	Mutation rewiring degron network	0.0556
p.T1053S	DO219688	KIRP	ICGC	IPPFED	LIG_APCC_ABBA_1	1038:1043	Mutation rewiring degron network	0.0556
p.R1123L	TCGA-55-7910	LUAD	TCGA	IVPFRE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.7316
p.R1123L	DO23669	LUAD	ICGC	IVPFRE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.7316
p.P1118T	TCGA-5M-AATA	COAD	TCGA	IVPFRE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.3056
p.V442M	TCGA-86-8358	LUAD	TCGA	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.0833
p.V442M	TCGA-EO-A22U	UCEC	TCGA	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.0833
p.V442M	DO25471	LUAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.0833
p.V442M	DO43755	UCEC	ICGC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.0833
p.D1043Y	TCGA-86-8358	LUAD	TCGA	IPPFED	LIG_APCC_ABBA_1	1038:1043	Mutation altering degron motif	0.7325
p.D1043Y	DO25471	LUAD	ICGC	IPPFED	LIG_APCC_ABBA_1	1038:1043	Mutation altering degron motif	0.7325
p.E1694Q	TCGA-91-6830	LUAD	TCGA	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation rewiring degron network	0.25
p.E1694Q	DO25867	LUAD	ICGC	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation rewiring degron network	0.25
p.P1329S	TCGA-A2-A0YI	BRCA	TCGA	DTTLYTSSP	CBL_PTK	1312:1320	Mutation rewiring degron network	0.0833
p.P1329S	DO4341	BRCA	ICGC	DTTLYTSSP	CBL_PTK	1312:1320	Mutation rewiring degron network	0.0833
p.V1033L	TCGA-A5-A0G1	UCEC	TCGA	IPPFED	LIG_APCC_ABBA_1	1038:1043	Mutation rewiring degron network	0.1944
p.V1033L	DO42472	UCEC	ICGC	IPPFED	LIG_APCC_ABBA_1	1038:1043	Mutation rewiring degron network	0.1944
p.E823A	TCGA-A8-A09Z	BRCA	TCGA	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.0556
p.E823A	DO5521	BRCA	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.0556
p.R1047Q	TCGA-AA-3538	COAD	TCGA	IPPFED	LIG_APCC_ABBA_1	1038:1043	Mutation rewiring degron network	0.2222
p.R1047Q	DO9626	COAD	ICGC	IPPFED	LIG_APCC_ABBA_1	1038:1043	Mutation rewiring degron network	0.2222
p.R1047Q	DO233634	GACA	ICGC	IPPFED	LIG_APCC_ABBA_1	1038:1043	Mutation rewiring degron network	0.2222
p.P1697S	TCGA-AA-3672	COAD	TCGA	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation altering degron motif	0.6752
p.P1697S	DO9010	COAD	ICGC	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation altering degron motif	0.6752
p.A466D	TCGA-AD-6964	COAD	TCGA	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.0556
p.A466D	DO8360	COAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.0556
p.P1698L	TCGA-AK-3465	KIRC	TCGA	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation altering degron motif	0.6471
p.I1119M	TCGA-AN-A0AK	BRCA	TCGA	IVPFRE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.6507
p.I1119M	DO1608	BRCA	ICGC	IVPFRE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.6507
p.S465G	TCGA-AP-A054	UCEC	TCGA	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.0833
p.S465G	DO42256	UCEC	ICGC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.0833
p.Y1506C	TCGA-AX-A063	UCEC	TCGA	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.1667
p.Y1506C	DO42201	UCEC	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.1667
p.L1693P	TCGA-B5-A1MW	UCEC	TCGA	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation rewiring degron network	0.2222
p.L1693P	DO42913	UCEC	ICGC	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation rewiring degron network	0.2222
p.A1494S	TCGA-B6-A0IQ	BRCA	TCGA	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation altering degron motif	0.6477
p.A1494S	DO4847	BRCA	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation altering degron motif	0.6477
p.K1034T	TCGA-BQ-5882	KIRP	TCGA	IPPFED	LIG_APCC_ABBA_1	1038:1043	Mutation substituting flanking lysine	0.3333
p.K1034T	DO20758	KIRP	ICGC	IPPFED	LIG_APCC_ABBA_1	1038:1043	Mutation substituting flanking lysine	0.3333
p.A460T	TCGA-BR-4257	STAD	TCGA	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.2222
p.A460T	DO38683	STAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.2222
p.S1692G	TCGA-BR-8372	STAD	TCGA	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation blocking phosphorylation signal	0.6389
p.S1692G	DO47873	STAD	ICGC	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation blocking phosphorylation signal	0.6389
p.G1044D	TCGA-BS-A0TE	UCEC	TCGA	IPPFED	LIG_APCC_ABBA_1	1038:1043	Mutation rewiring degron network	0.3056
p.G1044D	DO43506	UCEC	ICGC	IPPFED	LIG_APCC_ABBA_1	1038:1043	Mutation rewiring degron network	0.3056
p.M117I	TCGA-D3-A2JP	SKCM	TCGA	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation rewiring degron network	0.0833
p.M117I	TCGA-D3-A2JP	SKCM	TCGA	PPTST	DEG_SPOP_SBC_1	125:129	Mutation rewiring degron network	0.1111
p.M117I	DO47407	SKCM	ICGC	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation rewiring degron network	0.0833
p.M117I	DO47407	SKCM	ICGC	PPTST	DEG_SPOP_SBC_1	125:129	Mutation rewiring degron network	0.1111
p.P837R	TCGA-D8-A1JP	BRCA	TCGA	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation altering degron motif	0.7512
p.P837R	DO5857	BRCA	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation altering degron motif	0.7512
p.E1694D	TCGA-DK-A2I4	BLCA	TCGA	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation rewiring degron network	0.25
p.E1694D	DO465	BLCA	ICGC	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation rewiring degron network	0.25
p.E1694D	ACH-000600	Kidney Cancer	CCLE	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation rewiring degron network	0.25
p.P1490L	TCGA-E6-A2P8	UCEC	TCGA	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.2778
p.P1490L	DO234459	ESAD	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.2778
p.P1490L	DO40924	UCEC	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.2778
p.L825F	TCGA-E9-A22E	BRCA	TCGA	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1111
p.L825F	DO2131	BRCA	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1111
p.S848F	TCGA-EB-A41A	SKCM	TCGA	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1111
p.S848F	DO37429	SKCM	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1111
p.P1502S	TCGA-EE-A2GC	SKCM	TCGA	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.2778
p.P1502S	DO37839	SKCM	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.2778
p.P1502L	TCGA-EE-A2GC	SKCM	TCGA	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.2778
p.P1502L	DO37839	SKCM	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.2778
p.P1121L	TCGA-EE-A2GJ	SKCM	TCGA	IVPFRE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.6471
p.P1121L	DO37746	SKCM	ICGC	IVPFRE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.6471
p.K1303N	TCGA-EE-A2GO	SKCM	TCGA	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation substituting flanking lysine	0.3056
p.K1303N	TCGA-EE-A2GO	SKCM	TCGA	DTTLYTSSP	CBL_PTK	1312:1320	Mutation substituting flanking lysine	0.1944
p.K1303N	DO37823	SKCM	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation substituting flanking lysine	0.3056
p.K1303N	DO37823	SKCM	ICGC	DTTLYTSSP	CBL_PTK	1312:1320	Mutation substituting flanking lysine	0.1944
p.Q121H	TCGA-EO-A22R	UCEC	TCGA	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation rewiring degron network	0.1944
p.Q121H	TCGA-EO-A22R	UCEC	TCGA	PPTST	DEG_SPOP_SBC_1	125:129	Mutation rewiring degron network	0.2222
p.Q121H	DO42713	UCEC	ICGC	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation rewiring degron network	0.1944
p.Q121H	DO42713	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	125:129	Mutation rewiring degron network	0.2222
p.E1708K	TCGA-EP-A2KC	LIHC	TCGA	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation rewiring degron network	0.1944
p.E1708K	DO22966	LIHC	ICGC	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation rewiring degron network	0.1944
p.P837H	TCGA-ER-A2NE	SKCM	TCGA	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation altering degron motif	0.7694
p.P837H	DO48663	SKCM	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation altering degron motif	0.7694
p.S448F	TCGA-FS-A4F9	SKCM	TCGA	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.25
p.S448F	DO38069	SKCM	ICGC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.25
p.D1308Y	TCGA-FU-A3TQ	CESC	TCGA	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation altering degron motif	0.7325
p.D1308Y	DO44295	CESC	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation altering degron motif	0.7325
p.D1308Y	DO229041	LICA	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation altering degron motif	0.7325
p.L828M	TCGA-IB-7651	PAAD	TCGA	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1944
p.L828M	DO46657	PAAD	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1944
p.R140L	TCGA-L9-A7SV	LUAD	TCGA	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation rewiring degron network	0.1389
p.R140L	DO49875	LUAD	ICGC	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation rewiring degron network	0.1389
p.R140Q	TCGA-OR-A5KB	ACC	TCGA	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation rewiring degron network	0.1389
p.A466T	TCGA-VQ-A8PD	STAD	TCGA	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.0556
p.A466T	DO51768	STAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.0556
p.R388L	DO936	BOCA	ICGC	AFTST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.0556
p.G842S	DO220824	BRCA	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.2778
p.G394D	DO227646	COCA	ICGC	AFTST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.2222
p.R1500Q	DO222492	COCA	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation altering degron motif	0.6218
p.R1500Q	SIDM00213	Thyroid Gland Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation altering degron motif	0.6218
p.R1500Q	ACH-000903	Thyroid Cancer	CCLE	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation altering degron motif	0.6218
p.R1500Q	FTC-133	thyroid	COSMIC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation altering degron motif	0.6218
p.D1299E	DO229003	COCA	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM00303	Ovarian Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM01034	B-Lymphoblastic Leukemia	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM00589	Oral Cavity Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM00492	Glioblastoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM00905	Cervical Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM00054	Pancreatic Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM00294	Small Cell Lung Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM00498	Colorectal Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM00618	Hepatocellular Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM00613	Glioblastoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM00503	Gastric Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM01018	Hodgkin's Lymphoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM01727	Chronic Myelogenous Leukemia	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM01577	Plasma Cell Myeloma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM01470	Acute Myeloid Leukemia	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM01749	Osteosarcoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM01320	Pancreatic Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM01776	Plasma Cell Myeloma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM01378	Ovarian Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.D1299E	SIDM01574	Plasma Cell Myeloma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.R1503W	DO50448	ESAD	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.R1503W	SIDM01278	Colorectal Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.R1503W	SIDM01020	Plasma Cell Myeloma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.R1503W	SIDM00586	Hepatocellular Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.R1503W	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.R1503W	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.R1503W	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.R1503W	SIDM00596	Endometrial Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.R1503W	SIDM00410	Other Blood Cancers	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.R1503W	SIDM00609	Kidney Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.R1503W	SIDM01019	Acute Myeloid Leukemia	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.R1503W	SIDM00239	Kidney Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.R1503W	SIDM00603	Head and Neck Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.R1503W	SIDM01735	Biliary Tract Carcinoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.S1707T	DO234194	ESAD	ICGC	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation blocking phosphorylation signal	0.6667
p.E456K	DO222636	ESCA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation altering degron motif	0.7022
p.G393R	DO233088	GACA	ICGC	AFTST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1944
p.G393R	SIDM00024	Non-Cancerous	GDSC	AFTST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1944
p.G393R	ACH-001699	Head and Neck Cancer	CCLE	AFTST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.1944
p.S116F	DO233652	GACA	ICGC	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation rewiring degron network	0.0556
p.S116F	DO233652	GACA	ICGC	PPTST	DEG_SPOP_SBC_1	125:129	Mutation rewiring degron network	0.0833
p.S116F	DO220892	MELA	ICGC	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation rewiring degron network	0.0556
p.S116F	DO220892	MELA	ICGC	PPTST	DEG_SPOP_SBC_1	125:129	Mutation rewiring degron network	0.0833
p.D1299G	DO233864	GACA	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.R1330Q	DO233941	GACA	ICGC	DTTLYTSSP	CBL_PTK	1312:1320	Mutation rewiring degron network	0.0556
p.R446W	DO229346	LAML	ICGC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.1944
p.G1310V	DO228948	LICA	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation altering degron motif	0.7532
p.K1115N	DO229018	LICA	ICGC	IVPFRE	LIG_APCC_ABBA_1	1119:1124	Mutation substituting flanking lysine	0.3333
p.D827Y	DO229022	LICA	ICGC	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1667
p.S454I	DO229025	LICA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation altering degron motif	0.7341
p.A1326S	DO229025	LICA	ICGC	DTTLYTSSP	CBL_PTK	1312:1320	Mutation rewiring degron network	0.1667
p.V1486F	DO229025	LICA	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.1667
p.G457V	DO229024	LICA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.3056
p.S443I	DO229026	LICA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.1111
p.G1044V	DO229031	LICA	ICGC	IPPFED	LIG_APCC_ABBA_1	1038:1043	Mutation rewiring degron network	0.3056
p.M1323I	DO229031	LICA	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0833
p.M1323I	DO229031	LICA	ICGC	DTTLYTSSP	CBL_PTK	1312:1320	Mutation rewiring degron network	0.25
p.G134V	DO229008	LICA	ICGC	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation rewiring degron network	0.3056
p.G134V	DO229008	LICA	ICGC	PPTST	DEG_SPOP_SBC_1	125:129	Mutation rewiring degron network	0.1944
p.A131T	DO50970	LICA	ICGC	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation altering degron motif	0.6028
p.S465N	DO23236	LINC	ICGC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.0833
p.N1485T	DO228372	MALY	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.1389
p.S1324F	DO220891	MELA	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0556
p.S1324F	DO220891	MELA	ICGC	DTTLYTSSP	CBL_PTK	1312:1320	Mutation rewiring degron network	0.2222
p.S1324F	SIDM00867	Glioblastoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0556
p.S1324F	SIDM00867	Glioblastoma	GDSC	DTTLYTSSP	CBL_PTK	1312:1320	Mutation rewiring degron network	0.2222
p.S1324F	ACH-000863	Brain Cancer	CCLE	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0556
p.S1324F	ACH-000863	Brain Cancer	CCLE	DTTLYTSSP	CBL_PTK	1312:1320	Mutation rewiring degron network	0.2222
p.S1324F	DBTRG-05MG	central nervous system	COSMIC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.0556
p.S1324F	DBTRG-05MG	central nervous system	COSMIC	DTTLYTSSP	CBL_PTK	1312:1320	Mutation rewiring degron network	0.2222
p.R1112W	DO220912	MELA	ICGC	IVPFRE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.1389
p.H115Y	DO222743	MELA	ICGC	PPTST	DEG_SPOP_SBC_1	125:129	Mutation rewiring degron network	0.0556
p.E1709D	DO46374	OV	ICGC	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation rewiring degron network	0.1667
p.S1495F	DO229453	SKCA	ICGC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation altering degron motif	0.7982
p.P1040S	DO229456	SKCA	ICGC	IPPFED	LIG_APCC_ABBA_1	1038:1043	Mutation altering degron motif	0.6752
p.S135F	SIDM02041	Colorectal Carcinoma	GDSC	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation blocking phosphorylation signal	0.7222
p.S135F	SIDM02041	Colorectal Carcinoma	GDSC	PPTST	DEG_SPOP_SBC_1	125:129	Mutation blocking phosphorylation signal	0.6111
p.S133P	SIDM01954	Colorectal Carcinoma	GDSC	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation altering degron motif	0.7863
p.S1306C	SIDM02030	Colorectal Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation rewiring degron network	0.2778
p.S1306C	SIDM02030	Colorectal Carcinoma	GDSC	DTTLYTSSP	CBL_PTK	1312:1320	Mutation rewiring degron network	0.1667
p.A131V	SIDM00377	Other Sarcomas	GDSC	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation altering degron motif	0.5825
p.A131V	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation altering degron motif	0.5825
p.A131V	SIDM00380	Acute Myeloid Leukemia	GDSC	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation altering degron motif	0.5825
p.A131V	SIDM00168	Head and Neck Carcinoma	GDSC	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation altering degron motif	0.5825
p.A131V	SKM-1	haematopoietic and lymphoid tissue	COSMIC	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation altering degron motif	0.5825
p.R1330L	SIDM00969	Ovarian Carcinoma	GDSC	DTTLYTSSP	CBL_PTK	1312:1320	Mutation rewiring degron network	0.0556
p.R1330L	SIDM00032	Bladder Carcinoma	GDSC	DTTLYTSSP	CBL_PTK	1312:1320	Mutation rewiring degron network	0.0556
p.R1330L	SIDM00808	Burkitt's Lymphoma	GDSC	DTTLYTSSP	CBL_PTK	1312:1320	Mutation rewiring degron network	0.0556
p.R1330L	SIDM01254	Burkitt's Lymphoma	GDSC	DTTLYTSSP	CBL_PTK	1312:1320	Mutation rewiring degron network	0.0556
p.R140P	SIDM01174	Cervical Carcinoma	GDSC	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation rewiring degron network	0.1389
p.R1503Q	SIDM00202	Ewing's Sarcoma	GDSC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.R1503Q	ACH-001057	Lymphoma	CCLE	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.R1503Q	ACH-002118	Bone Cancer	CCLE	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.R1503Q	EW-3	bone	COSMIC	LRASLRDLR	DEG_APCC_DBOX_1	1492:1500	Mutation rewiring degron network	0.25
p.K826E	SIDM00596	Endometrial Carcinoma	GDSC	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation substituting flanking lysine	0.25
p.K826E	ACH-000941	Endometrial/Uterine Cancer	CCLE	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation substituting flanking lysine	0.25
p.K826E	ACH-000954	Endometrial/Uterine Cancer	CCLE	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation substituting flanking lysine	0.25
p.K826E	ACH-001517	Endometrial/Uterine Cancer	CCLE	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation substituting flanking lysine	0.25
p.K826E	HEC-1	endometrium	COSMIC	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation substituting flanking lysine	0.25
p.K1131Q	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	IVPFRE	LIG_APCC_ABBA_1	1119:1124	Mutation substituting flanking lysine	0.25
p.K1131Q	ACH-000784	Esophageal Cancer	CCLE	IVPFRE	LIG_APCC_ABBA_1	1119:1124	Mutation substituting flanking lysine	0.25
p.K1131Q	KYSE-70	oesophagus	COSMIC	IVPFRE	LIG_APCC_ABBA_1	1119:1124	Mutation substituting flanking lysine	0.25
p.L825V	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1111
p.L825V	ACH-000861	Lung Cancer	CCLE	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1111
p.L825V	HOP-62	lung	COSMIC	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.1111
p.G1310S	SIDM00420	Bladder Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation altering degron motif	0.6993
p.G1310S	SIDM01525	Acute Myeloid Leukemia	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation altering degron motif	0.6993
p.G1310S	SW1710	urinary tract	COSMIC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation altering degron motif	0.6993
p.M1706I	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation rewiring degron network	0.25
p.M1706I	ACH-002253	Lymphoma	CCLE	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation rewiring degron network	0.25
p.M1706I	JSC-1	haematopoietic and lymphoid tissue	COSMIC	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation rewiring degron network	0.25
p.A463V	SIDM00901	Endometrial Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.1389
p.A463V	ACH-000940	Endometrial/Uterine Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.1389
p.A463V	AN3-CA	endometrium	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.1389
p.V449M	SIDM00415	B-Cell Non-Hodgkin's Lymphoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.2778
p.V449M	ACH-001639	Leukemia	CCLE	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.2778
p.V449M	ROS-50	haematopoietic and lymphoid tissue	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.2778
p.D1312N	SIDM01679	Small Cell Lung Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1308:1314	Mutation altering degron motif	0.5821
p.D1312N	SIDM01679	Small Cell Lung Carcinoma	GDSC	DTTLYTSSP	CBL_PTK	1312:1320	Mutation altering degron motif	0.5821
p.G455S	SIDM00163	Biliary Tract Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation altering degron motif	0.6993
p.P1697A	ACH-000961	Endometrial/Uterine Cancer	CCLE	PPTPRTT	DEG_SCF_FBW7_1	1697:1703	Mutation altering degron motif	0.7503
p.S135P	ACH-000978	Endometrial/Uterine Cancer	CCLE	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation blocking phosphorylation signal	0.7222
p.S135P	ACH-000978	Endometrial/Uterine Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	125:129	Mutation blocking phosphorylation signal	0.6111
p.S135P	EN	endometrium	COSMIC	PTSTPASS	DEG_SCF_FBW7_1	126:133	Mutation blocking phosphorylation signal	0.7222
p.S135P	EN	endometrium	COSMIC	PPTST	DEG_SPOP_SBC_1	125:129	Mutation blocking phosphorylation signal	0.6111
p.P397T	ACH-001057	Lymphoma	CCLE	AFTST	DEG_SPOP_SBC_1	398:402	Mutation rewiring degron network	0.3056
p.N831D	ACH-001418	Ovarian Cancer	CCLE	VSNTPIDS	DEG_SCF_FBW7_1	833:840	Mutation rewiring degron network	0.2778
p.A447P	ACH-001554	Eye Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.2222
p.A447P	ACH-001955	Bone Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	451:456	Mutation rewiring degron network	0.2222
p.V1120I	ACH-002287	Colon/Colorectal Cancer	CCLE	IVPFRE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.5965
p.V1120I	NCI-H630	large intestine	COSMIC	IVPFRE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.5965

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SIPA1L3

UniProt ID: O60292

Entrez ID: 23094

Protein name: Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SIPA1L3 in