DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DTTLYTSSP
Uniprot ID:
O60292
Source protein:
Signal-induced proliferation-associated 1-like protein 3
Source gene:
SIPA1L3
Class:
CBL_PTK
Location:
1312:1320
E3 ligase:
CBL
DEGRON score:
0.9829
ASA_SCORE:
75.9
COIL:
0.8657
CONS_SCORE:
0.367
DSS_SCORE:
0.5285
HELIX:
0.0883
FCONS_SCORE:
0.9896
RIG_SCORE:
0.6926
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P1329S
TCGA-A2-A0YI
BRCA
TCGA
DTTLYTSSP
CBL_PTK
0.0833
p.P1329S
DO4341
BRCA
ICGC
DTTLYTSSP
CBL_PTK
0.0833
p.K1303N
TCGA-EE-A2GO
SKCM
TCGA
DTTLYTSSP
CBL_PTK
0.1944
p.K1303N
DO37823
SKCM
ICGC
DTTLYTSSP
CBL_PTK
0.1944
p.R1330Q
DO233941
GACA
ICGC
DTTLYTSSP
CBL_PTK
0.0556
p.A1326S
DO229025
LICA
ICGC
DTTLYTSSP
CBL_PTK
0.1667
p.M1323I
DO229031
LICA
ICGC
DTTLYTSSP
CBL_PTK
0.25
p.S1324F
DO220891
MELA
ICGC
DTTLYTSSP
CBL_PTK
0.2222
p.S1324F
SIDM00867
Glioblastoma
GDSC
DTTLYTSSP
CBL_PTK
0.2222
p.S1324F
ACH-000863
Brain Cancer
CCLE
DTTLYTSSP
CBL_PTK
0.2222
p.S1324F
DBTRG-05MG
central_nervous_system
COSMIC
DTTLYTSSP
CBL_PTK
0.2222
p.S1306C
SIDM02030
Colorectal Carcinoma
GDSC
DTTLYTSSP
CBL_PTK
0.1667
p.R1330L
SIDM00969
Ovarian Carcinoma
GDSC
DTTLYTSSP
CBL_PTK
0.0556
p.R1330L
SIDM00032
Bladder Carcinoma
GDSC
DTTLYTSSP
CBL_PTK
0.0556
p.R1330L
SIDM00808
Burkitt's Lymphoma
GDSC
DTTLYTSSP
CBL_PTK
0.0556
p.R1330L
SIDM01254
Burkitt's Lymphoma
GDSC
DTTLYTSSP
CBL_PTK
0.0556
p.D1312N
SIDM01679
Small Cell Lung Carcinoma
GDSC
DTTLYTSSP
CBL_PTK
0.5821
Drug responses associated with SIPA1L3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DTTLYTSSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60292
Signal-induced proliferation-associated 1-like protein 3
CBL_PTK
1312:1320
DTTLYTSSP
CBL
0.9829
More...
