DegronMD

Uniprot ID: O60292

Source protein: Signal-induced proliferation-associated 1-like protein 3

Source gene: SIPA1L3

Class: DEG_SCF_FBW7_1

Location: 1697:1703

E3 ligase: FBXW7

DEGRON score: 0.9848

ASA_SCORE: 99.6429

COIL: 0.9571

CONS_SCORE: 0.3937

DSS_SCORE: 0.7763

HELIX: 0.015

FCONS_SCORE: 1.0967

RIG_SCORE: 0.543

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1703I	TCGA-2W-A8YY	CESC	TCGA	PPTPRTT	DEG_SCF_FBW7_1	0.8189
p.T1703I	DO223732	CESC	ICGC	PPTPRTT	DEG_SCF_FBW7_1	0.8189
p.E1694Q	TCGA-91-6830	LUAD	TCGA	PPTPRTT	DEG_SCF_FBW7_1	0.25
p.E1694Q	DO25867	LUAD	ICGC	PPTPRTT	DEG_SCF_FBW7_1	0.25
p.P1697S	TCGA-AA-3672	COAD	TCGA	PPTPRTT	DEG_SCF_FBW7_1	0.6752
p.P1697S	DO9010	COAD	ICGC	PPTPRTT	DEG_SCF_FBW7_1	0.6752
p.P1698L	TCGA-AK-3465	KIRC	TCGA	PPTPRTT	DEG_SCF_FBW7_1	0.6471
p.L1693P	TCGA-B5-A1MW	UCEC	TCGA	PPTPRTT	DEG_SCF_FBW7_1	0.2222
p.L1693P	DO42913	UCEC	ICGC	PPTPRTT	DEG_SCF_FBW7_1	0.2222
p.S1692G	TCGA-BR-8372	STAD	TCGA	PPTPRTT	DEG_SCF_FBW7_1	0.6389
p.S1692G	DO47873	STAD	ICGC	PPTPRTT	DEG_SCF_FBW7_1	0.6389
p.E1694D	TCGA-DK-A2I4	BLCA	TCGA	PPTPRTT	DEG_SCF_FBW7_1	0.25
p.E1694D	DO465	BLCA	ICGC	PPTPRTT	DEG_SCF_FBW7_1	0.25
p.E1694D	ACH-000600	Kidney Cancer	CCLE	PPTPRTT	DEG_SCF_FBW7_1	0.25
p.E1708K	TCGA-EP-A2KC	LIHC	TCGA	PPTPRTT	DEG_SCF_FBW7_1	0.1944
p.E1708K	DO22966	LIHC	ICGC	PPTPRTT	DEG_SCF_FBW7_1	0.1944
p.S1707T	DO234194	ESAD	ICGC	PPTPRTT	DEG_SCF_FBW7_1	0.6667
p.E1709D	DO46374	OV	ICGC	PPTPRTT	DEG_SCF_FBW7_1	0.1667
p.M1706I	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPTPRTT	DEG_SCF_FBW7_1	0.25
p.M1706I	ACH-002253	Lymphoma	CCLE	PPTPRTT	DEG_SCF_FBW7_1	0.25
p.M1706I	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPRTT	DEG_SCF_FBW7_1	0.25
p.P1697A	ACH-000961	Endometrial/Uterine Cancer	CCLE	PPTPRTT	DEG_SCF_FBW7_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_SCF_FBW7_1	1697:1703	PPTPRTT	FBXW7	0.9848	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons