DegronMD

Uniprot ID: O60292

Source protein: Signal-induced proliferation-associated 1-like protein 3

Source gene: SIPA1L3

Class: LIG_APCC_ABBA_1

Location: 1119:1124

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9858

ASA_SCORE: 105.0167

COIL: 0.9118

CONS_SCORE: 0.3383

DSS_SCORE: 0.6426

HELIX: 0.0448

FCONS_SCORE: 0.958

RIG_SCORE: 0.7139

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1123W	TCGA-16-0848	GBM	TCGA	IVPFRE	LIG_APCC_ABBA_1	0.7523
p.R1123W	DO12196	GBM	ICGC	IVPFRE	LIG_APCC_ABBA_1	0.7523
p.R1123L	TCGA-55-7910	LUAD	TCGA	IVPFRE	LIG_APCC_ABBA_1	0.7316
p.R1123L	DO23669	LUAD	ICGC	IVPFRE	LIG_APCC_ABBA_1	0.7316
p.P1118T	TCGA-5M-AATA	COAD	TCGA	IVPFRE	LIG_APCC_ABBA_1	0.3056
p.I1119M	TCGA-AN-A0AK	BRCA	TCGA	IVPFRE	LIG_APCC_ABBA_1	0.6507
p.I1119M	DO1608	BRCA	ICGC	IVPFRE	LIG_APCC_ABBA_1	0.6507
p.P1121L	TCGA-EE-A2GJ	SKCM	TCGA	IVPFRE	LIG_APCC_ABBA_1	0.6471
p.P1121L	DO37746	SKCM	ICGC	IVPFRE	LIG_APCC_ABBA_1	0.6471
p.K1115N	DO229018	LICA	ICGC	IVPFRE	LIG_APCC_ABBA_1	0.3333
p.R1112W	DO220912	MELA	ICGC	IVPFRE	LIG_APCC_ABBA_1	0.1389
p.K1131Q	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	IVPFRE	LIG_APCC_ABBA_1	0.25
p.K1131Q	ACH-000784	Esophageal Cancer	CCLE	IVPFRE	LIG_APCC_ABBA_1	0.25
p.K1131Q	KYSE-70	oesophagus	COSMIC	IVPFRE	LIG_APCC_ABBA_1	0.25
p.V1120I	ACH-002287	Colon/Colorectal Cancer	CCLE	IVPFRE	LIG_APCC_ABBA_1	0.5965
p.V1120I	NCI-H630	large_intestine	COSMIC	IVPFRE	LIG_APCC_ABBA_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60292	Signal-induced proliferation-associated 1-like protein 3	LIG_APCC_ABBA_1	1119:1124	IVPFRE	APC,CDC20,FZR1	0.9858	More...
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	LIG_APCC_ABBA_1	1056:1061	IVPFRE	APC,CDC20,FZR1	0.5362	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons