DegronMD

Uniprot ID: P98160

Source protein: Basement membrane-specific heparan sulfate proteoglycan core protein

Source gene: HSPG2

Class: LIG_APCC_ABBA_1

Location: 1056:1061

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5362

ASA_SCORE: 58.4167

COIL: 0.3245

CONS_SCORE: 0.3769

DSS_SCORE: 0.557

HELIX: 0.0378

FCONS_SCORE: 1.0792

RIG_SCORE: 0.8034

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1055V	TCGA-06-5416	GBM	TCGA	IVPFRE	LIG_APCC_ABBA_1	0.3056
p.F1055V	DO10880	GBM	ICGC	IVPFRE	LIG_APCC_ABBA_1	0.3056
p.Q1062K	TCGA-13-0884	OV	TCGA	IVPFRE	LIG_APCC_ABBA_1	0.3056
p.Q1062K	DO28913	OV	ICGC	IVPFRE	LIG_APCC_ABBA_1	0.3056
p.D1068N	TCGA-29-1697	OV	TCGA	IVPFRE	LIG_APCC_ABBA_1	0.1389
p.D1068N	DO230326	COCA	ICGC	IVPFRE	LIG_APCC_ABBA_1	0.1389
p.D1068N	DO28140	OV	ICGC	IVPFRE	LIG_APCC_ABBA_1	0.1389
p.R1060W	TCGA-B5-A11H	UCEC	TCGA	IVPFRE	LIG_APCC_ABBA_1	0.7523
p.R1060W	DO42825	UCEC	ICGC	IVPFRE	LIG_APCC_ABBA_1	0.7523
p.R1066W	TCGA-B5-A1MW	UCEC	TCGA	IVPFRE	LIG_APCC_ABBA_1	0.1944
p.R1066W	DO42913	UCEC	ICGC	IVPFRE	LIG_APCC_ABBA_1	0.1944
p.V1057L	TCGA-C5-A1MN	CESC	TCGA	IVPFRE	LIG_APCC_ABBA_1	0.5654
p.V1057L	DO6257	CESC	ICGC	IVPFRE	LIG_APCC_ABBA_1	0.5654
p.D1068G	TCGA-E6-A1LX	UCEC	TCGA	IVPFRE	LIG_APCC_ABBA_1	0.1389
p.D1068G	DO41020	UCEC	ICGC	IVPFRE	LIG_APCC_ABBA_1	0.1389
p.I1056T	TCGA-EL-A4K9	THCA	TCGA	IVPFRE	LIG_APCC_ABBA_1	0.7078
p.I1056T	DO39139	THCA	ICGC	IVPFRE	LIG_APCC_ABBA_1	0.7078
p.P1058R	DO225065	BRCA	ICGC	IVPFRE	LIG_APCC_ABBA_1	0.7512
p.P1049S	DO222796	BTCA	ICGC	IVPFRE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60292	Signal-induced proliferation-associated 1-like protein 3	LIG_APCC_ABBA_1	1119:1124	IVPFRE	APC,CDC20,FZR1	0.9858	More...
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	LIG_APCC_ABBA_1	1056:1061	IVPFRE	APC,CDC20,FZR1	0.5362	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons