DegronMD - P98160(HSPG2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F1055V	TCGA-06-5416	GBM	TCGA	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation rewiring degron network	0.3056
p.F1055V	DO10880	GBM	ICGC	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation rewiring degron network	0.3056
p.E259D	TCGA-12-1088	GBM	TCGA	VETTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.E259D	DO13701	GBM	ICGC	VETTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.Q1062K	TCGA-13-0884	OV	TCGA	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation rewiring degron network	0.3056
p.Q1062K	DO28913	OV	ICGC	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation rewiring degron network	0.3056
p.E3418V	TCGA-19-1790	GBM	TCGA	VQVTPQLE	DEG_SCF_FBW7_2	3402:3409	Mutation rewiring degron network	0.0833
p.E3418V	DO12328	GBM	ICGC	VQVTPQLE	DEG_SCF_FBW7_2	3402:3409	Mutation rewiring degron network	0.0833
p.D1068N	TCGA-29-1697	OV	TCGA	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation rewiring degron network	0.1389
p.D1068N	DO230326	COCA	ICGC	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation rewiring degron network	0.1389
p.D1068N	DO28140	OV	ICGC	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation rewiring degron network	0.1389
p.G2775D	TCGA-2W-A8YY	CESC	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.3056
p.G2775D	DO223732	CESC	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.3056
p.G2775S	TCGA-2W-A8YY	CESC	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.3056
p.G2775S	DO223732	CESC	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.3056
p.R1716W	TCGA-2W-A8YY	CESC	TCGA	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.0833
p.R1716W	DO223732	CESC	ICGC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.0833
p.R1133C	TCGA-2W-A8YY	CESC	TCGA	PPGY	ITCH	1129:1132	Mutation rewiring degron network	0.3056
p.R1133C	TCGA-DU-7012	LGG	TCGA	PPGY	ITCH	1129:1132	Mutation rewiring degron network	0.3056
p.R1133C	DO223732	CESC	ICGC	PPGY	ITCH	1129:1132	Mutation rewiring degron network	0.3056
p.R1133C	DO22187	LGG	ICGC	PPGY	ITCH	1129:1132	Mutation rewiring degron network	0.3056
p.C1137F	TCGA-86-7713	LUAD	TCGA	PPGY	ITCH	1129:1132	Mutation rewiring degron network	0.1944
p.C1137F	DO24712	LUAD	ICGC	PPGY	ITCH	1129:1132	Mutation rewiring degron network	0.1944
p.S1695F	TCGA-90-A4ED	LUSC	TCGA	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.0833
p.S1695F	TCGA-L5-A43I	ESCA	TCGA	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.0833
p.S1695F	DO233793	GACA	ICGC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.0833
p.S1695F	DO45482	LUSC	ICGC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.0833
p.S1695F	SIDM01106	Melanoma	GDSC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.0833
p.S1695F	ACH-000822	Skin Cancer	CCLE	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.0833
p.S1695F	SK-MEL-24	skin	COSMIC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.0833
p.R2794P	TCGA-90-A59Q	LUSC	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.0556
p.R2794P	DO50103	LUSC	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.0556
p.C2793F	TCGA-90-A59Q	LUSC	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.0833
p.C2793F	DO50103	LUSC	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.0833
p.M263T	TCGA-95-7567	LUAD	TCGA	VETTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0556
p.M263T	DO25564	LUAD	ICGC	VETTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0556
p.R1712C	TCGA-AJ-A3BH	UCEC	TCGA	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1944
p.R1712C	TCGA-FD-A62S	BLCA	TCGA	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1944
p.R1712C	DO44044	BLCA	ICGC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1944
p.R1712C	DO41638	UCEC	ICGC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1944
p.R2794Q	TCGA-AP-A0LM	UCEC	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.0556
p.R2794Q	DO43306	UCEC	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.0556
p.R2794Q	SIDM01147	Gastric Carcinoma	GDSC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.0556
p.L2767I	TCGA-AP-A1DK	UCEC	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.0833
p.L2767I	DO42033	UCEC	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.0833
p.R1060W	TCGA-B5-A11H	UCEC	TCGA	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation altering degron motif	0.7523
p.R1060W	DO42825	UCEC	ICGC	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation altering degron motif	0.7523
p.R1066W	TCGA-B5-A1MW	UCEC	TCGA	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation rewiring degron network	0.1944
p.R1066W	DO42913	UCEC	ICGC	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation rewiring degron network	0.1944
p.V1057L	TCGA-C5-A1MN	CESC	TCGA	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation altering degron motif	0.5654
p.V1057L	DO6257	CESC	ICGC	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation altering degron motif	0.5654
p.S1711P	TCGA-CI-6621	READ	TCGA	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.2222
p.S1711P	DO36970	READ	ICGC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.2222
p.R2777L	TCGA-CN-A63W	HNSC	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation altering degron motif	0.8428
p.R2777L	TCGA-L9-A7SV	LUAD	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation altering degron motif	0.8428
p.R2777L	DO49031	HNSC	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation altering degron motif	0.8428
p.R2777L	DO49875	LUAD	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation altering degron motif	0.8428
p.R2794W	TCGA-CV-6955	HNSC	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.0556
p.R2794W	DO14338	HNSC	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.0556
p.Q1699K	TCGA-D3-A1Q1	SKCM	TCGA	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1944
p.Q1699K	DO37445	SKCM	ICGC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1944
p.Q2772H	TCGA-D3-A1Q3	SKCM	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.2222
p.Y1132F	TCGA-DD-AACK	LIHC	TCGA	PPGY	ITCH	1129:1132	Mutation altering degron motif	0.7528
p.Y1132F	DO52207	LIHC	ICGC	PPGY	ITCH	1129:1132	Mutation altering degron motif	0.7528
p.D1068G	TCGA-E6-A1LX	UCEC	TCGA	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation rewiring degron network	0.1389
p.D1068G	DO41020	UCEC	ICGC	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation rewiring degron network	0.1389
p.A1883V	TCGA-E7-A8O8	BLCA	TCGA	PTPTLE	DEG_SCF_FBW7_2	1893:1898	Mutation rewiring degron network	0.0556
p.A1883V	DO219020	BLCA	ICGC	PTPTLE	DEG_SCF_FBW7_2	1893:1898	Mutation rewiring degron network	0.0556
p.A1883V	SIDM00854	Burkitt's Lymphoma	GDSC	PTPTLE	DEG_SCF_FBW7_2	1893:1898	Mutation rewiring degron network	0.0556
p.A1883V	SIDM00828	Other Sarcomas	GDSC	PTPTLE	DEG_SCF_FBW7_2	1893:1898	Mutation rewiring degron network	0.0556
p.A1883V	SIDM01085	Bladder Carcinoma	GDSC	PTPTLE	DEG_SCF_FBW7_2	1893:1898	Mutation rewiring degron network	0.0556
p.R2779W	TCGA-ED-A66Y	LIHC	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation altering degron motif	0.7523
p.R2779W	DO230346	COCA	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation altering degron motif	0.7523
p.R2779W	DO44874	LIHC	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation altering degron motif	0.7523
p.P1705L	TCGA-EE-A2MH	SKCM	TCGA	PPHY	ITCH	1704:1707	Mutation altering degron motif	0.7582
p.P1705L	DO222628	MELA	ICGC	PPHY	ITCH	1704:1707	Mutation altering degron motif	0.7582
p.P1705L	DO37539	SKCM	ICGC	PPHY	ITCH	1704:1707	Mutation altering degron motif	0.7582
p.Q1699H	TCGA-EE-A3AD	SKCM	TCGA	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1944
p.Q1699H	DO37707	SKCM	ICGC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1944
p.I1056T	TCGA-EL-A4K9	THCA	TCGA	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation altering degron motif	0.7078
p.I1056T	DO39139	THCA	ICGC	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation altering degron motif	0.7078
p.S2486L	TCGA-EO-A3B0	UCEC	TCGA	SRLRLLQVT	DEG_APCC_DBOX_1	2486:2494	Mutation altering degron motif	0.7667
p.S2486L	DO219773	UCEC	ICGC	SRLRLLQVT	DEG_APCC_DBOX_1	2486:2494	Mutation altering degron motif	0.7667
p.V2625M	TCGA-EY-A548	UCEC	TCGA	SGSSHVPSV	DEG_COP1_1	2620:2628	Mutation altering degron motif	0.7208
p.V2625M	DO48173	UCEC	ICGC	SGSSHVPSV	DEG_COP1_1	2620:2628	Mutation altering degron motif	0.7208
p.V3402M	TCGA-F4-6808	COAD	TCGA	VQVTPQLE	DEG_SCF_FBW7_2	3402:3409	Mutation altering degron motif	0.6097
p.V3402M	DO8946	COAD	ICGC	VQVTPQLE	DEG_SCF_FBW7_2	3402:3409	Mutation altering degron motif	0.6097
p.S242I	TCGA-FS-A1Z0	SKCM	TCGA	VETTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.S242I	DO37431	SKCM	ICGC	VETTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.R1697L	TCGA-FS-A1ZR	SKCM	TCGA	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1389
p.R1697L	DO37651	SKCM	ICGC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1389
p.V2615I	TCGA-G4-6320	COAD	TCGA	SGSSHVPSV	DEG_COP1_1	2620:2628	Mutation rewiring degron network	0.1944
p.V2615I	DO8159	COAD	ICGC	SGSSHVPSV	DEG_COP1_1	2620:2628	Mutation rewiring degron network	0.1944
p.V2615I	SIDM00535	Chondrosarcoma	GDSC	SGSSHVPSV	DEG_COP1_1	2620:2628	Mutation rewiring degron network	0.1944
p.S2769G	TCGA-HU-A4H8	STAD	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.1389
p.S2769G	DO47869	STAD	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.1389
p.R1697W	TCGA-MX-A5UJ	STAD	TCGA	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1389
p.R1697W	DO233940	GACA	ICGC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1389
p.R1697W	DO48547	STAD	ICGC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1389
p.R1697W	SIDM00216	Colorectal Carcinoma	GDSC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1389
p.R1697W	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1389
p.R1697W	ACH-000953	Leukemia	CCLE	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1389
p.R1697W	ACH-000989	Colon/Colorectal Cancer	CCLE	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1389
p.R1697W	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1389
p.P2768S	TCGA-OD-A75X	SKCM	TCGA	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.1111
p.P2768S	DO48601	SKCM	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.1111
p.T1894M	TCGA-OR-A5LK	ACC	TCGA	PTPTLE	DEG_SCF_FBW7_2	1893:1898	Mutation altering degron motif	0.7423
p.P2478L	TCGA-QC-A7B5	SARC	TCGA	SRLRLLQVT	DEG_APCC_DBOX_1	2486:2494	Mutation rewiring degron network	0.1111
p.P2478L	DO220239	SARC	ICGC	SRLRLLQVT	DEG_APCC_DBOX_1	2486:2494	Mutation rewiring degron network	0.1111
p.P2478S	TCGA-QC-A7B5	SARC	TCGA	SRLRLLQVT	DEG_APCC_DBOX_1	2486:2494	Mutation rewiring degron network	0.1111
p.P2478S	DO220239	SARC	ICGC	SRLRLLQVT	DEG_APCC_DBOX_1	2486:2494	Mutation rewiring degron network	0.1111
p.P3028L	TCGA-S9-A6TS	LGG	TCGA	PPSST	DEG_SPOP_SBC_1	3028:3032	Mutation altering degron motif	0.7582
p.P3028L	DO50181	LGG	ICGC	PPSST	DEG_SPOP_SBC_1	3028:3032	Mutation altering degron motif	0.7582
p.P1058R	DO225065	BRCA	ICGC	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation altering degron motif	0.7512
p.D2787E	DO225090	BRCA	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.25
p.D1141N	DO224917	BRCA	ICGC	PPGY	ITCH	1129:1132	Mutation rewiring degron network	0.0833
p.P1049S	DO222796	BTCA	ICGC	IVPFRE	LIG_APCC_ABBA_1	1056:1061	Mutation rewiring degron network	0.1389
p.T2616S	DO7262	CLLE	ICGC	SGSSHVPSV	DEG_COP1_1	2620:2628	Mutation rewiring degron network	0.2222
p.M263I	DO230309	COCA	ICGC	VETTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0556
p.M263I	SIDM00309	Mesothelioma	GDSC	VETTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0556
p.G1131R	DO233254	GACA	ICGC	PPGY	ITCH	1129:1132	Mutation altering degron motif	0.6457
p.A1889T	DO233823	GACA	ICGC	PTPTLE	DEG_SCF_FBW7_2	1893:1898	Mutation rewiring degron network	0.2222
p.R2489G	DO229493	LAML	ICGC	SRLRLLQVT	DEG_APCC_DBOX_1	2486:2494	Mutation altering degron motif	0.6457
p.Q1906K	DO229019	LICA	ICGC	PTPTLE	DEG_SCF_FBW7_2	1893:1898	Mutation rewiring degron network	0.1111
p.P1895T	DO229022	LICA	ICGC	PTPTLE	DEG_SCF_FBW7_2	1893:1898	Mutation altering degron motif	0.7031
p.H1706N	DO229022	LICA	ICGC	PPHY	ITCH	1704:1707	Mutation altering degron motif	0.6312
p.H2781N	DO229032	LICA	ICGC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation altering degron motif	0.6312
p.S2627R	DO229036	LICA	ICGC	SGSSHVPSV	DEG_COP1_1	2620:2628	Mutation altering degron motif	0.7427
p.T1896N	DO229037	LICA	ICGC	PTPTLE	DEG_SCF_FBW7_2	1893:1898	Mutation altering degron motif	0.5944
p.D1141E	DO229006	LICA	ICGC	PPGY	ITCH	1129:1132	Mutation rewiring degron network	0.0833
p.F3419L	DO44810	LICA	ICGC	VQVTPQLE	DEG_SCF_FBW7_2	3402:3409	Mutation rewiring degron network	0.0556
p.R2480W	DO231075	LUSC	ICGC	SRLRLLQVT	DEG_APCC_DBOX_1	2486:2494	Mutation rewiring degron network	0.1667
p.R2480W	SIDM01199	Hepatocellular Carcinoma	GDSC	SRLRLLQVT	DEG_APCC_DBOX_1	2486:2494	Mutation rewiring degron network	0.1667
p.R2480W	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	SRLRLLQVT	DEG_APCC_DBOX_1	2486:2494	Mutation rewiring degron network	0.1667
p.R2480W	SIDM00489	Oral Cavity Carcinoma	GDSC	SRLRLLQVT	DEG_APCC_DBOX_1	2486:2494	Mutation rewiring degron network	0.1667
p.R2480W	SIDM01434	Hepatocellular Carcinoma	GDSC	SRLRLLQVT	DEG_APCC_DBOX_1	2486:2494	Mutation rewiring degron network	0.1667
p.G1905N	DO222843	MELA	ICGC	PTPTLE	DEG_SCF_FBW7_2	1893:1898	Mutation rewiring degron network	0.1389
p.T252K	DO232849	NACA	ICGC	VETTS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7306
p.S2612L	DO34616	PACA	ICGC	SGSSHVPSV	DEG_COP1_1	2620:2628	Mutation rewiring degron network	0.1111
p.P3395S	DO232761	PBCA	ICGC	VQVTPQLE	DEG_SCF_FBW7_2	3402:3409	Mutation rewiring degron network	0.1389
p.P3395S	ACH-000423	Skin Cancer	CCLE	VQVTPQLE	DEG_SCF_FBW7_2	3402:3409	Mutation rewiring degron network	0.1389
p.V2625A	DO232761	PBCA	ICGC	SGSSHVPSV	DEG_COP1_1	2620:2628	Mutation altering degron motif	0.6936
p.P3022L	DO229234	THCA	ICGC	PPSST	DEG_SPOP_SBC_1	3028:3032	Mutation rewiring degron network	0.1667
p.R1716L	DO41199	UCEC	ICGC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.0833
p.V3033M	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPSST	DEG_SPOP_SBC_1	3028:3032	Mutation rewiring degron network	0.3056
p.V3033M	ACH-000365	Lymphoma	CCLE	PPSST	DEG_SPOP_SBC_1	3028:3032	Mutation rewiring degron network	0.3056
p.V3033M	SU-DHL-4	haematopoietic and lymphoid tissue	COSMIC	PPSST	DEG_SPOP_SBC_1	3028:3032	Mutation rewiring degron network	0.3056
p.S3412G	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VQVTPQLE	DEG_SCF_FBW7_2	3402:3409	Mutation rewiring degron network	0.25
p.C1126R	SIDM00216	Colorectal Carcinoma	GDSC	PPGY	ITCH	1129:1132	Mutation rewiring degron network	0.25
p.C1126R	ACH-000989	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	1129:1132	Mutation rewiring degron network	0.25
p.S2788L	SIDM00615	Hepatocellular Carcinoma	GDSC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.2222
p.S2788L	ACH-000217	Liver Cancer	CCLE	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.2222
p.S2788L	JHH-6	liver	COSMIC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.2222
p.R1886C	SIDM01090	Colorectal Carcinoma	GDSC	PTPTLE	DEG_SCF_FBW7_2	1893:1898	Mutation rewiring degron network	0.1389
p.R1886C	RKO	large intestine	COSMIC	PTPTLE	DEG_SCF_FBW7_2	1893:1898	Mutation rewiring degron network	0.1389
p.R2774H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.2778
p.R2774H	ACH-002256	Leukemia	CCLE	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.2778
p.R2774H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.2778
p.R2777Q	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation altering degron motif	0.7329
p.R2777Q	SIDM01336	Glioblastoma	GDSC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation altering degron motif	0.7329
p.Y2791C	SIDM01045	Endometrial Carcinoma	GDSC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.1389
p.Y2791C	ACH-000978	Endometrial/Uterine Cancer	CCLE	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.1389
p.Y2791C	EN	endometrium	COSMIC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.1389
p.P1129Q	SIDM00054	Pancreatic Carcinoma	GDSC	PPGY	ITCH	1129:1132	Mutation altering degron motif	0.7035
p.P1129Q	ACH-001619	Gallbladder Cancer	CCLE	PPGY	ITCH	1129:1132	Mutation altering degron motif	0.7035
p.P1129Q	ACH-002185	Pancreatic Cancer	CCLE	PPGY	ITCH	1129:1132	Mutation altering degron motif	0.7035
p.P1129Q	PL18	pancreas	COSMIC	PPGY	ITCH	1129:1132	Mutation altering degron motif	0.7035
p.V1700F	SIDM00511	Small Cell Lung Carcinoma	GDSC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.2222
p.V1700F	ACH-000257	Lung Cancer	CCLE	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.2222
p.V1700F	COR-L279	lung	COSMIC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.2222
p.P2785L	SIDM00254	Neuroblastoma	GDSC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.3056
p.S2627G	SIDM00217	Colorectal Carcinoma	GDSC	SGSSHVPSV	DEG_COP1_1	2620:2628	Mutation altering degron motif	0.6993
p.S2627G	ACH-000999	Colon/Colorectal Cancer	CCLE	SGSSHVPSV	DEG_COP1_1	2620:2628	Mutation altering degron motif	0.6993
p.S2627G	SNU-1040	large intestine	COSMIC	SGSSHVPSV	DEG_COP1_1	2620:2628	Mutation altering degron motif	0.6993
p.V2792M	SIDM01228	Melanoma	GDSC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.1111
p.V2792M	CHL-1	skin	COSMIC	SRLRLHHVS	DEG_APCC_DBOX_1	2776:2784	Mutation rewiring degron network	0.1111
p.Q1699P	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1944
p.Q1699P	ACH-000416	Lung Cancer	CCLE	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1944
p.Q1699P	NCI-H838	lung	COSMIC	PPHY	ITCH	1704:1707	Mutation rewiring degron network	0.1944
p.I241M	ACH-000694	Esophageal Cancer	CCLE	VETTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1111
p.F245L	ACH-000901	Lung Cancer	CCLE	VETTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2222
p.A1120V	ACH-000941	Endometrial/Uterine Cancer	CCLE	PPGY	ITCH	1129:1132	Mutation rewiring degron network	0.0833
p.R2504L	ACH-001608	Brain Cancer	CCLE	SRLRLLQVT	DEG_APCC_DBOX_1	2486:2494	Mutation rewiring degron network	0.0556
p.P255S	ACH-001982	Metastasis	CCLE	VETTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.V2493M	ACH-002026	Endometrial/Uterine Cancer	CCLE	SRLRLLQVT	DEG_APCC_DBOX_1	2486:2494	Mutation altering degron motif	0.6097

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HSPG2

UniProt ID: P98160

Entrez ID: 3339

Protein name: Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HSPG2 in