DegronMD

Uniprot ID: P98160

Source protein: Basement membrane-specific heparan sulfate proteoglycan core protein

Source gene: HSPG2

Class: ITCH

Location: 1704:1707

E3 ligase: ITCH,NEDD4

DEGRON score: 0.6355

ASA_SCORE: 72.85

COIL: 0.6275

CONS_SCORE: 0.3742

DSS_SCORE: 0.4363

HELIX: 0.011

FCONS_SCORE: 1.1357

RIG_SCORE: 0.6699

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1716W	TCGA-2W-A8YY	CESC	TCGA	PPHY	ITCH	0.0833
p.R1716W	DO223732	CESC	ICGC	PPHY	ITCH	0.0833
p.S1695F	TCGA-90-A4ED	LUSC	TCGA	PPHY	ITCH	0.0833
p.S1695F	TCGA-L5-A43I	ESCA	TCGA	PPHY	ITCH	0.0833
p.S1695F	DO233793	GACA	ICGC	PPHY	ITCH	0.0833
p.S1695F	DO45482	LUSC	ICGC	PPHY	ITCH	0.0833
p.S1695F	SIDM01106	Melanoma	GDSC	PPHY	ITCH	0.0833
p.S1695F	ACH-000822	Skin Cancer	CCLE	PPHY	ITCH	0.0833
p.S1695F	SK-MEL-24	skin	COSMIC	PPHY	ITCH	0.0833
p.R1712C	TCGA-AJ-A3BH	UCEC	TCGA	PPHY	ITCH	0.1944
p.R1712C	TCGA-FD-A62S	BLCA	TCGA	PPHY	ITCH	0.1944
p.R1712C	DO44044	BLCA	ICGC	PPHY	ITCH	0.1944
p.R1712C	DO41638	UCEC	ICGC	PPHY	ITCH	0.1944
p.S1711P	TCGA-CI-6621	READ	TCGA	PPHY	ITCH	0.2222
p.S1711P	DO36970	READ	ICGC	PPHY	ITCH	0.2222
p.Q1699K	TCGA-D3-A1Q1	SKCM	TCGA	PPHY	ITCH	0.1944
p.Q1699K	DO37445	SKCM	ICGC	PPHY	ITCH	0.1944
p.P1705L	TCGA-EE-A2MH	SKCM	TCGA	PPHY	ITCH	0.7582
p.P1705L	DO222628	MELA	ICGC	PPHY	ITCH	0.7582
p.P1705L	DO37539	SKCM	ICGC	PPHY	ITCH	0.7582
p.Q1699H	TCGA-EE-A3AD	SKCM	TCGA	PPHY	ITCH	0.1944
p.Q1699H	DO37707	SKCM	ICGC	PPHY	ITCH	0.1944
p.R1697L	TCGA-FS-A1ZR	SKCM	TCGA	PPHY	ITCH	0.1389
p.R1697L	DO37651	SKCM	ICGC	PPHY	ITCH	0.1389
p.R1697W	TCGA-MX-A5UJ	STAD	TCGA	PPHY	ITCH	0.1389
p.R1697W	DO233940	GACA	ICGC	PPHY	ITCH	0.1389
p.R1697W	DO48547	STAD	ICGC	PPHY	ITCH	0.1389
p.R1697W	SIDM00216	Colorectal Carcinoma	GDSC	PPHY	ITCH	0.1389
p.R1697W	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PPHY	ITCH	0.1389
p.R1697W	ACH-000953	Leukemia	CCLE	PPHY	ITCH	0.1389
p.R1697W	ACH-000989	Colon/Colorectal Cancer	CCLE	PPHY	ITCH	0.1389
p.R1697W	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PPHY	ITCH	0.1389
p.H1706N	DO229022	LICA	ICGC	PPHY	ITCH	0.6312
p.R1716L	DO41199	UCEC	ICGC	PPHY	ITCH	0.0833
p.V1700F	SIDM00511	Small Cell Lung Carcinoma	GDSC	PPHY	ITCH	0.2222
p.V1700F	ACH-000257	Lung Cancer	CCLE	PPHY	ITCH	0.2222
p.V1700F	COR-L279	lung	COSMIC	PPHY	ITCH	0.2222
p.Q1699P	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	PPHY	ITCH	0.1944
p.Q1699P	ACH-000416	Lung Cancer	CCLE	PPHY	ITCH	0.1944
p.Q1699P	NCI-H838	lung	COSMIC	PPHY	ITCH	0.1944

Drug responses associated with HSPG2 mutations

All proteins holding degron of PPHY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15156	Zinc finger and BTB domain-containing protein 7B	ITCH	468:471	PPHY	ITCH,NEDD4	0.632	More...
O75081	Protein CBFA2T3	ITCH	339:342	PPHY	ITCH,NEDD4	0.9949	More...
O75618	Death effector domain-containing protein	ITCH	146:149	PPHY	ITCH,NEDD4	0.9035	More...
O75923	Dysferlin	ITCH	194:197	PPHY	ITCH,NEDD4	0.877	More...
O94855	Protein transport protein Sec24D	ITCH	23:26	PPHY	ITCH,NEDD4	0.9579	More...
P14866	Heterogeneous nuclear ribonucleoprotein L	ITCH	337:340	PPHY	ITCH,NEDD4	0.9935	More...
P56693	Transcription factor SOX-10	ITCH	366:369	PPHY	ITCH,NEDD4	0.9951	More...
P62072	Mitochondrial import inner membrane translocase subunit Tim10	ITCH	35:38	PPHY	ITCH,NEDD4	0.6439	More...
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	ITCH	1704:1707	PPHY	ITCH,NEDD4	0.6355	More...
Q13227	G protein pathway suppressor 2	ITCH	194:197	PPHY	ITCH,NEDD4	0.9693	More...
Q13621	Solute carrier family 12 member 1	ITCH	42:45	PPHY	ITCH,NEDD4	0.9792	More...
Q6W2J9	BCL-6 corepressor	ITCH	249:252	PPHY	ITCH,NEDD4	0.7281	More...
Q6ZRV2	Protein FAM83H	ITCH	21:24	PPHY	ITCH,NEDD4	0.9628	More...
Q7Z4S6	Kinesin-like protein KIF21A	ITCH	1540:1543	PPHY	ITCH,NEDD4	0.7904	More...
Q86Y56	Dynein axonemal assembly factor 5	ITCH	335:338	PPHY	ITCH,NEDD4	0.6455	More...
Q8NC67	Neuropilin and tolloid-like protein 2	ITCH	395:398	PPHY	ITCH,NEDD4	0.9529	More...
Q8NEA6	Zinc finger protein GLIS3	ITCH	680:683	PPHY	ITCH,NEDD4	0.969	More...
Q8NFH8	RalBP1-associated Eps domain-containing protein 2	ITCH	200:203	PPHY	ITCH,NEDD4	0.9985	More...
Q9NZB2	Constitutive coactivator of PPAR-gamma-like protein 1	ITCH	339:342	PPHY	ITCH,NEDD4	0.7758	More...
Q9Y2G1	Myelin regulatory factor	ITCH	195:198	PPHY	ITCH,NEDD4	0.9944	More...
Q9Y2K2	Serine/threonine-protein kinase SIK3	ITCH	939:942	PPHY	ITCH,NEDD4	0.9973	More...
Q8TF68	Zinc finger protein 384	ITCH	46:49	PPHY	ITCH,NEDD4	0.9991	More...
Q96A35	39S ribosomal protein L24, mitochondrial	ITCH	16:19	PPHY	ITCH,NEDD4	0.837	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPHY

Degron related mutations and impact score

Drug responses associated with HSPG2 mutations

All proteins holding degron of PPHY