DegronMD - O75081(CBFA2T3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R317Q	TCGA-19-5956	GBM	TCGA	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.1944
p.R317Q	DO13863	GBM	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.1944
p.R317Q	ACH-001390	Breast Cancer	CCLE	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.1944
p.R306S	TCGA-75-6211	LUAD	TCGA	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.7427
p.R306S	DO25173	LUAD	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.7427
p.V469M	TCGA-A6-6780	COAD	TCGA	PRSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.0556
p.V469M	DO10244	COAD	ICGC	PRSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.0556
p.R298M	TCGA-AX-A2HC	UCEC	TCGA	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.1111
p.R298M	DO41572	UCEC	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.1111
p.P340L	TCGA-CX-7082	HNSC	TCGA	PPHY	ITCH	339:342	Mutation altering degron motif	0.7582
p.R343H	TCGA-D1-A17L	UCEC	TCGA	PPHY	ITCH	339:342	Mutation rewiring degron network	0.3056
p.R343H	DO40847	UCEC	ICGC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.3056
p.G303R	TCGA-EE-A2GO	SKCM	TCGA	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.25
p.G303R	DO37823	SKCM	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.25
p.P465L	TCGA-FI-A2D5	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1667
p.P465L	DO41331	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1667
p.G303E	TCGA-FR-A728	SKCM	TCGA	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.25
p.P338Q	TCGA-FS-A1Z0	SKCM	TCGA	PPHY	ITCH	339:342	Mutation rewiring degron network	0.3056
p.P338Q	DO37431	SKCM	ICGC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.3056
p.C143R	TCGA-G4-6302	COAD	TCGA	PATSS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.0833
p.A348S	TCGA-GN-A266	SKCM	TCGA	PPHY	ITCH	339:342	Mutation rewiring degron network	0.1667
p.P450T	TCGA-L9-A444	LUAD	TCGA	PRSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1944
p.P450T	DO26015	LUAD	ICGC	PRSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1944
p.E463K	TCGA-MY-A913	CESC	TCGA	PRSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.2222
p.E463K	DO49980	CESC	ICGC	PRSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.2222
p.R147Q	DO10459	COAD	ICGC	PATSS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1944
p.R320H	DO8786	COAD	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.1111
p.R320H	DO227695	PACA	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.1111
p.R320H	DO37251	READ	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.1111
p.Q462H	DO8240	COAD	ICGC	PRSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.25
p.R330C	DO222864	COCA	ICGC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.0833
p.R330C	DO38607	STAD	ICGC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.0833
p.R330C	DO42129	UCEC	ICGC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.0833
p.D297N	DO222877	COCA	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.0833
p.P301L	DO233768	GACA	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.1944
p.P334L	DO233905	GACA	ICGC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.1944
p.P142Q	DO16037	HNSC	ICGC	PATSS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.0556
p.P302L	DO14268	HNSC	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.2222
p.R340Q	DO44868	LICA	ICGC	PPHY	ITCH	339:342	Mutation altering degron motif	0.7329
p.E351K	DO23018	LIHC	ICGC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.0833
p.E307K	DO222402	MELA	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.7022
p.D165N	DO222731	MELA	ICGC	PATSS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.0833
p.D165N	DO229218	THCA	ICGC	PATSS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.0833
p.R306H	DO218861	SKCA	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.8244
p.R306H	SIDM00957	Colorectal Carcinoma	GDSC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.8244
p.R306H	ACH-000350	Colon/Colorectal Cancer	CCLE	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.8244
p.A310S	DO37432	SKCM	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.7588
p.R316Q	DO51774	STAD	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation substituting flanking lysine	0.3333
p.E301D	DO229224	THCA	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.1944
p.R343C	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.3056
p.R343C	ACH-000983	Leukemia	CCLE	PPHY	ITCH	339:342	Mutation rewiring degron network	0.3056
p.R343C	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.3056
p.T157A	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PATSS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.3056
p.T157A	SIDM01685	B-Lymphoblastic Leukemia	GDSC	PATSS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.3056
p.T157A	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PATSS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.3056
p.P340S	SIDM00433	T-Lymphoblastic Leukemia	GDSC	PPHY	ITCH	339:342	Mutation altering degron motif	0.6752
p.P340S	ACH-000795	Leukemia	CCLE	PPHY	ITCH	339:342	Mutation altering degron motif	0.6752
p.P340S	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	PPHY	ITCH	339:342	Mutation altering degron motif	0.6752
p.A451T	SIDM00262	Ewing's Sarcoma	GDSC	PRSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.2222
p.A451T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.2222
p.A451T	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.2222
p.A451T	ACH-000964	Leukemia	CCLE	PRSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.2222
p.A451T	ACH-001127	Leukemia	CCLE	PRSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.2222
p.A451T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.2222
p.A451T	ES6	bone	COSMIC	PRSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.2222
p.R306G	SIDM01120	Other Solid Cancers	GDSC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.7568
p.E312K	SIDM00383	Gastric Carcinoma	GDSC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.7022
p.E312K	SIDM00280	Gastric Carcinoma	GDSC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.7022
p.E312K	SIDM00560	Gastric Carcinoma	GDSC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.7022
p.E312K	SIDM01709	Melanoma	GDSC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.7022
p.E312K	SCH	stomach	COSMIC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.7022
p.E312K	ECC10	stomach	COSMIC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.7022
p.E312K	MKN7	stomach	COSMIC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.7022
p.P318S	SIDM00487	Colorectal Carcinoma	GDSC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.1667
p.P318S	ACH-000963	Colon/Colorectal Cancer	CCLE	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.1667
p.P318S	CCK-81	large intestine	COSMIC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.1667
p.P311A	SIDM00324	Neuroblastoma	GDSC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.6392
p.P311A	ACH-001674	Neuroblastoma	CCLE	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.6392
p.P311A	TGW	autonomic ganglia	COSMIC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.6392
p.P329L	SIDM00380	Acute Myeloid Leukemia	GDSC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.0556
p.P329L	ACH-000373	Leukemia	CCLE	PPHY	ITCH	339:342	Mutation rewiring degron network	0.0556
p.P329L	SKM-1	haematopoietic and lymphoid tissue	COSMIC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.0556
p.H310Y	ACH-000761	Gastric Cancer	CCLE	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.6118
p.L309P	ACH-000963	Colon/Colorectal Cancer	CCLE	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation altering degron motif	0.7582
p.D297G	ACH-001354	Neuroblastoma	CCLE	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.0833
p.A350T	ACH-001518	Endometrial/Uterine Cancer	CCLE	PPHY	ITCH	339:342	Mutation rewiring degron network	0.1111
p.I297F	DSH1	urinary tract	COSMIC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	306:312	Mutation rewiring degron network	0.0833
p.R335H	SNU-1040	large intestine	COSMIC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.2222
p.H163Y	HCC1806	breast	COSMIC	PATSS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1389
p.R351C	NCC010	kidney	COSMIC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.0833
p.R350W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.1111
p.E468K	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.0833
p.R351H	PF-382	haematopoietic and lymphoid tissue	COSMIC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CBFA2T3

UniProt ID: O75081

Entrez ID: 863

Protein name: Protein CBFA2T3 (MTG8-related protein 2) (Myeloid translocation gene on chromosome 16 protein) (hMTG16) (Zinc finger MYND domain-containing protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CBFA2T3 in