DegronMD

Uniprot ID: O75081

Source protein: Protein CBFA2T3

Source gene: CBFA2T3

Class: LIG_APCC_ABBAyCdc20_2

Location: 306:312

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.917

ASA_SCORE: 92.0857

COIL: 0.8403

CONS_SCORE: 0.4532

DSS_SCORE: 0.7737

HELIX: 0.1403

FCONS_SCORE: 1.0522

RIG_SCORE: 0.5989

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R317Q	TCGA-19-5956	GBM	TCGA	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R317Q	DO13863	GBM	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R317Q	ACH-001390	Breast Cancer	CCLE	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R306S	TCGA-75-6211	LUAD	TCGA	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.7427
p.R306S	DO25173	LUAD	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.7427
p.R298M	TCGA-AX-A2HC	UCEC	TCGA	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R298M	DO41572	UCEC	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G303R	TCGA-EE-A2GO	SKCM	TCGA	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.25
p.G303R	DO37823	SKCM	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.25
p.G303E	TCGA-FR-A728	SKCM	TCGA	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.25
p.R320H	DO8786	COAD	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R320H	DO227695	PACA	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R320H	DO37251	READ	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.1111
p.D297N	DO222877	COCA	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.P301L	DO233768	GACA	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P302L	DO14268	HNSC	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E307K	DO222402	MELA	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.7022
p.R306H	DO218861	SKCA	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R306H	SIDM00957	Colorectal Carcinoma	GDSC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R306H	ACH-000350	Colon/Colorectal Cancer	CCLE	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.8244
p.A310S	DO37432	SKCM	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.7588
p.R316Q	DO51774	STAD	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.3333
p.E301D	DO229224	THCA	ICGC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R306G	SIDM01120	Other Solid Cancers	GDSC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.7568
p.E312K	SIDM00383	Gastric Carcinoma	GDSC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E312K	SIDM00280	Gastric Carcinoma	GDSC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E312K	SIDM00560	Gastric Carcinoma	GDSC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E312K	SIDM01709	Melanoma	GDSC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E312K	SCH	stomach	COSMIC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E312K	ECC10	stomach	COSMIC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E312K	MKN7	stomach	COSMIC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.7022
p.P318S	SIDM00487	Colorectal Carcinoma	GDSC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P318S	ACH-000963	Colon/Colorectal Cancer	CCLE	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P318S	CCK-81	large_intestine	COSMIC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P311A	SIDM00324	Neuroblastoma	GDSC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.6392
p.P311A	ACH-001674	Neuroblastoma	CCLE	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.6392
p.P311A	TGW	autonomic_ganglia	COSMIC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.6392
p.H310Y	ACH-000761	Gastric Cancer	CCLE	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.6118
p.L309P	ACH-000963	Colon/Colorectal Cancer	CCLE	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.7582
p.D297G	ACH-001354	Neuroblastoma	CCLE	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.I297F	DSH1	urinary_tract	COSMIC	RDPLHPE	LIG_APCC_ABBAyCdc20_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RDPLHPE

Degron related mutations and impact score

Drug responses associated with CBFA2T3 mutations

All proteins holding degron of RDPLHPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75081	Protein CBFA2T3	LIG_APCC_ABBAyCdc20_2	306:312	RDPLHPE	APC,CDC20,FZR1	0.917	More...