DegronMD - O15156(ZBTB7B)

FUNCTION: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity). {ECO:0000250|UniProtKB:Q64321, ECO:0000269|PubMed:9370309}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G543V	TCGA-69-A59K	LUAD	TCGA	PTTPQAE	DEG_SCF_FBW7_2	527:533	Mutation rewiring degron network	0.0556
p.N522S	TCGA-91-6835	LUAD	TCGA	PTTPQAE	DEG_SCF_FBW7_2	527:533	Mutation rewiring degron network	0.1944
p.N522S	TCGA-D1-A15X	UCEC	TCGA	PTTPQAE	DEG_SCF_FBW7_2	527:533	Mutation rewiring degron network	0.1944
p.R481C	TCGA-A5-A0G2	UCEC	TCGA	PPHY	ITCH	468:471	Mutation rewiring degron network	0.0556
p.R481C	TCGA-B5-A3S1	UCEC	TCGA	PPHY	ITCH	468:471	Mutation rewiring degron network	0.0556
p.R481C	SIDM02041	Colorectal Carcinoma	GDSC	PPHY	ITCH	468:471	Mutation rewiring degron network	0.0556
p.F535C	TCGA-B5-A1MR	UCEC	TCGA	PTTPQAE	DEG_SCF_FBW7_2	527:533	Mutation rewiring degron network	0.2778
p.R462Q	TCGA-C8-A26Z	BRCA	TCGA	PPHY	ITCH	468:471	Mutation rewiring degron network	0.1667
p.E476D	TCGA-D3-A2JO	SKCM	TCGA	PPHY	ITCH	468:471	Mutation rewiring degron network	0.1944
p.G460R	TCGA-EE-A2GT	SKCM	TCGA	PPHY	ITCH	468:471	Mutation rewiring degron network	0.1111
p.K475N	TCGA-EE-A2MQ	SKCM	TCGA	PPHY	ITCH	468:471	Mutation rewiring degron network	0.2222
p.D477G	TCGA-HC-A8D1	PRAD	TCGA	PPHY	ITCH	468:471	Mutation rewiring degron network	0.1667
p.A540V	TCGA-VQ-A91E	STAD	TCGA	PTTPQAE	DEG_SCF_FBW7_2	527:533	Mutation rewiring degron network	0.1389
p.D466N	DO225009	BRCA	ICGC	PPHY	ITCH	468:471	Mutation rewiring degron network	0.2778
p.D466N	DO52556	BRCA	ICGC	PPHY	ITCH	468:471	Mutation rewiring degron network	0.2778
p.D466N	DO35315	PACA	ICGC	PPHY	ITCH	468:471	Mutation rewiring degron network	0.2778
p.E523Q	DO224847	BRCA	ICGC	PTTPQAE	DEG_SCF_FBW7_2	527:533	Mutation rewiring degron network	0.2222
p.E523Q	DO227473	BRCA	ICGC	PTTPQAE	DEG_SCF_FBW7_2	527:533	Mutation rewiring degron network	0.2222
p.R463L	DO233622	GACA	ICGC	PPHY	ITCH	468:471	Mutation rewiring degron network	0.1944
p.R458C	DO233764	GACA	ICGC	PPHY	ITCH	468:471	Mutation rewiring degron network	0.0556
p.R458C	DO10880	GBM	ICGC	PPHY	ITCH	468:471	Mutation rewiring degron network	0.0556
p.A479T	DO41644	UCEC	ICGC	PPHY	ITCH	468:471	Mutation rewiring degron network	0.1111
p.D519N	SIDM02021	Esophageal Carcinoma	GDSC	PTTPQAE	DEG_SCF_FBW7_2	527:533	Mutation rewiring degron network	0.1111
p.M536L	ACH-000865	Esophageal Cancer	CCLE	PTTPQAE	DEG_SCF_FBW7_2	527:533	Mutation rewiring degron network	0.25
p.E524G	ACH-000994	Endometrial/Uterine Cancer	CCLE	PTTPQAE	DEG_SCF_FBW7_2	527:533	Mutation rewiring degron network	0.25
p.T459P	MOLM-16	haematopoietic and lymphoid tissue	COSMIC	PPHY	ITCH	468:471	Mutation rewiring degron network	0.0833

Kaplan plot for ZBTB7B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZBTB7B

UniProt ID: O15156

Entrez ID: 51043

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZBTB7B in