DegronMD

Uniprot ID: O15156

Source protein: Zinc finger and BTB domain-containing protein 7B

Source gene: ZBTB7B

Class: DEG_SCF_FBW7_2

Location: 527:533

E3 ligase: FBXW7

DEGRON score: 0.6434

ASA_SCORE: 91.6

COIL: 0.8384

CONS_SCORE: 0.5033

DSS_SCORE: 0.9742

HELIX: 0.1459

FCONS_SCORE: 0.8805

RIG_SCORE: 0.6116

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G543V	TCGA-69-A59K	LUAD	TCGA	PTTPQAE	DEG_SCF_FBW7_2	0.0556
p.N522S	TCGA-91-6835	LUAD	TCGA	PTTPQAE	DEG_SCF_FBW7_2	0.1944
p.N522S	TCGA-D1-A15X	UCEC	TCGA	PTTPQAE	DEG_SCF_FBW7_2	0.1944
p.F535C	TCGA-B5-A1MR	UCEC	TCGA	PTTPQAE	DEG_SCF_FBW7_2	0.2778
p.A540V	TCGA-VQ-A91E	STAD	TCGA	PTTPQAE	DEG_SCF_FBW7_2	0.1389
p.E523Q	DO224847	BRCA	ICGC	PTTPQAE	DEG_SCF_FBW7_2	0.2222
p.E523Q	DO227473	BRCA	ICGC	PTTPQAE	DEG_SCF_FBW7_2	0.2222
p.D519N	SIDM02021	Esophageal Carcinoma	GDSC	PTTPQAE	DEG_SCF_FBW7_2	0.1111
p.M536L	ACH-000865	Esophageal Cancer	CCLE	PTTPQAE	DEG_SCF_FBW7_2	0.25
p.E524G	ACH-000994	Endometrial/Uterine Cancer	CCLE	PTTPQAE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15156	Zinc finger and BTB domain-containing protein 7B	DEG_SCF_FBW7_2	527:533	PTTPQAE	FBXW7	0.6434	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons