DegronMD - O75923(DYSF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1801Q	TCGA-37-3789	LUSC	TCGA	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.1111
p.F205S	TCGA-43-7656	LUSC	TCGA	PPHY	ITCH	194:197	Mutation rewiring degron network	0.1111
p.D1827N	TCGA-AJ-A3EL	UCEC	TCGA	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.0556
p.D1827N	TCGA-EO-A22R	UCEC	TCGA	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.0556
p.D1827N	SIDM01611	Endometrial Carcinoma	GDSC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.0556
p.D1827N	ACH-000996	Endometrial/Uterine Cancer	CCLE	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.0556
p.D191Y	TCGA-AP-A1DV	UCEC	TCGA	PPHY	ITCH	194:197	Mutation blocking phosphorylation signal	0.6944
p.F81L	TCGA-AX-A06H	UCEC	TCGA	VLATPSLS	DEG_SCF_FBW7_1	91:98	Mutation rewiring degron network	0.0556
p.P1801L	TCGA-BR-4368	STAD	TCGA	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.1111
p.G196E	TCGA-CQ-5333	HNSC	TCGA	PPHY	ITCH	194:197	Mutation altering degron motif	0.7199
p.E1818K	TCGA-EE-A29L	SKCM	TCGA	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.3056
p.P105L	TCGA-EE-A29V	SKCM	TCGA	VLATPSLS	DEG_SCF_FBW7_1	91:98	Mutation rewiring degron network	0.1389
p.P105L	DO38006	SKCM	ICGC	VLATPSLS	DEG_SCF_FBW7_1	91:98	Mutation rewiring degron network	0.1389
p.R1807L	TCGA-EO-A22R	UCEC	TCGA	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.2778
p.L206M	TCGA-G7-6797	KIRP	TCGA	PPHY	ITCH	194:197	Mutation rewiring degron network	0.0833
p.L206M	DO20917	KIRP	ICGC	PPHY	ITCH	194:197	Mutation rewiring degron network	0.0833
p.T191A	DO223086	ESCA	ICGC	PPHY	ITCH	194:197	Mutation blocking phosphorylation signal	0.6944
p.A94T	DO233260	GACA	ICGC	VLATPSLS	DEG_SCF_FBW7_1	91:98	Mutation altering degron motif	0.7139
p.E1804D	DO229025	LICA	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation blocking phosphorylation signal	0.6389
p.E203D	DO229006	LICA	ICGC	PPHY	ITCH	194:197	Mutation substituting flanking lysine	0.2778
p.Q1818H	DO229006	LICA	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.3056
p.T184M	DO23210	LINC	ICGC	PPHY	ITCH	194:197	Mutation blocking phosphorylation signal	0.5
p.T184M	ACH-000869	Lung Cancer	CCLE	PPHY	ITCH	194:197	Mutation blocking phosphorylation signal	0.5
p.Q1822K	DO228451	MALY	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.1944
p.E1810K	DO222599	MELA	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation altering degron motif	0.7022
p.E1810K	DO37835	SKCM	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation altering degron motif	0.7022
p.P96L	DO222837	MELA	ICGC	VLATPSLS	DEG_SCF_FBW7_1	91:98	Mutation altering degron motif	0.7582
p.P1809L	DO33091	PACA	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation altering degron motif	0.7582
p.V1805I	DO46905	RECA	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.2222
p.P1808S	DO37442	SKCM	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.3056
p.Y1809N	DO229213	THCA	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation altering degron motif	0.7059
p.D190Y	DO43186	UCEC	ICGC	PPHY	ITCH	194:197	Mutation rewiring degron network	0.2222
p.D1806N	DO41542	UCEC	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.25
p.D1806N	DO42713	UCEC	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.25
p.A100D	SIDM02063	Colorectal Carcinoma	GDSC	VLATPSLS	DEG_SCF_FBW7_1	91:98	Mutation rewiring degron network	0.2778
p.S1806P	SIDM00680	Colorectal Carcinoma	GDSC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.25
p.S1806P	ACH-000957	Colon/Colorectal Cancer	CCLE	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.25
p.S1806P	LS-180	large intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.25
p.D108G	SIDM00983	Bladder Carcinoma	GDSC	VLATPSLS	DEG_SCF_FBW7_1	91:98	Mutation rewiring degron network	0.0556
p.D108G	ACH-000896	Bladder Cancer	CCLE	VLATPSLS	DEG_SCF_FBW7_1	91:98	Mutation rewiring degron network	0.0556
p.D108G	647-V	urinary tract	COSMIC	VLATPSLS	DEG_SCF_FBW7_1	91:98	Mutation rewiring degron network	0.0556
p.P96H	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	VLATPSLS	DEG_SCF_FBW7_1	91:98	Mutation altering degron motif	0.7694
p.P96H	ACH-000875	Lung Cancer	CCLE	VLATPSLS	DEG_SCF_FBW7_1	91:98	Mutation altering degron motif	0.7694
p.P96H	NCI-H2347	lung	COSMIC	VLATPSLS	DEG_SCF_FBW7_1	91:98	Mutation altering degron motif	0.7694
p.E1802D	SIDM00534	Colorectal Carcinoma	GDSC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.1389
p.E1802D	ACH-000986	Colon/Colorectal Cancer	CCLE	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.1389
p.E1802D	HT-115	large intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.1389
p.G1820W	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.25
p.V1826I	ACH-000706	Lung Cancer	CCLE	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.0833
p.L1809I	ACH-000954	Endometrial/Uterine Cancer	CCLE	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation altering degron motif	0.7174
p.M1824I	ACH-000985	Colon/Colorectal Cancer	CCLE	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.1389
p.L93F	ACH-001513	Cervical Cancer	CCLE	VLATPSLS	DEG_SCF_FBW7_1	91:98	Mutation altering degron motif	0.6981
p.L106R	ACH-002024	Colon/Colorectal Cancer	CCLE	VLATPSLS	DEG_SCF_FBW7_1	91:98	Mutation rewiring degron network	0.1111
p.P95H	NCI-H2347	lung	COSMIC	VLATPSLS	DEG_SCF_FBW7_1	91:98	Mutation altering degron motif	0.7694
p.S1805P	LS-180	large intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.2222
p.E1801D	HT-115	large intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.1111
p.L1826P	KM12	large intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.0833
p.L1815P	KM12	large intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation altering degron motif	0.7582
p.D107G	647-V	urinary tract	COSMIC	VLATPSLS	DEG_SCF_FBW7_1	91:98	Mutation rewiring degron network	0.0833
p.L1825P	KM12	large intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.1111
p.L1816P	KM12	large intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation altering degron motif	0.7582
p.L1802P	KM12	large intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.1389
p.L1811P	KM12	large intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation altering degron motif	0.7582
p.S1799P	LS-180	large intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation rewiring degron network	0.0556
p.L1812P	KM12	large intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	1809:1817	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DYSF

UniProt ID: O75923

Entrez ID: 8291

Protein name: Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DYSF in