DegronMD

Uniprot ID: O75923

Source protein: Dysferlin

Source gene: DYSF

Class: DEG_SCF_FBW7_1

Location: 91:98

E3 ligase: FBXW7

DEGRON score: 0.5442

ASA_SCORE: 57.2125

COIL: 0.6545

CONS_SCORE: 0.236

DSS_SCORE: 0.26

HELIX: 0.0624

FCONS_SCORE: 0.9073

RIG_SCORE: 0.769

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F81L	TCGA-AX-A06H	UCEC	TCGA	VLATPSLS	DEG_SCF_FBW7_1	0.0556
p.P105L	TCGA-EE-A29V	SKCM	TCGA	VLATPSLS	DEG_SCF_FBW7_1	0.1389
p.P105L	DO38006	SKCM	ICGC	VLATPSLS	DEG_SCF_FBW7_1	0.1389
p.A94T	DO233260	GACA	ICGC	VLATPSLS	DEG_SCF_FBW7_1	0.7139
p.P96L	DO222837	MELA	ICGC	VLATPSLS	DEG_SCF_FBW7_1	0.7582
p.A100D	SIDM02063	Colorectal Carcinoma	GDSC	VLATPSLS	DEG_SCF_FBW7_1	0.2778
p.D108G	SIDM00983	Bladder Carcinoma	GDSC	VLATPSLS	DEG_SCF_FBW7_1	0.0556
p.D108G	ACH-000896	Bladder Cancer	CCLE	VLATPSLS	DEG_SCF_FBW7_1	0.0556
p.D108G	647-V	urinary_tract	COSMIC	VLATPSLS	DEG_SCF_FBW7_1	0.0556
p.P96H	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	VLATPSLS	DEG_SCF_FBW7_1	0.7694
p.P96H	ACH-000875	Lung Cancer	CCLE	VLATPSLS	DEG_SCF_FBW7_1	0.7694
p.P96H	NCI-H2347	lung	COSMIC	VLATPSLS	DEG_SCF_FBW7_1	0.7694
p.L93F	ACH-001513	Cervical Cancer	CCLE	VLATPSLS	DEG_SCF_FBW7_1	0.6981
p.L106R	ACH-002024	Colon/Colorectal Cancer	CCLE	VLATPSLS	DEG_SCF_FBW7_1	0.1111
p.P95H	NCI-H2347	lung	COSMIC	VLATPSLS	DEG_SCF_FBW7_1	0.7694
p.D107G	647-V	urinary_tract	COSMIC	VLATPSLS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75923	Dysferlin	DEG_SCF_FBW7_1	91:98	VLATPSLS	FBXW7	0.5442	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons