DegronMD

Uniprot ID: O75923

Source protein: Dysferlin

Source gene: DYSF

Class: DEG_APCC_DBOX_1

Location: 1809:1817

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5736

ASA_SCORE: 48.6444

COIL: 0.2243

CONS_SCORE: 0.5772

DSS_SCORE: 0.044

HELIX: 0.0196

FCONS_SCORE: 1.1762

RIG_SCORE: 0.9674

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1801Q	TCGA-37-3789	LUSC	TCGA	RRFFLRCII	DEG_APCC_DBOX_1	0.1111
p.D1827N	TCGA-AJ-A3EL	UCEC	TCGA	RRFFLRCII	DEG_APCC_DBOX_1	0.0556
p.D1827N	TCGA-EO-A22R	UCEC	TCGA	RRFFLRCII	DEG_APCC_DBOX_1	0.0556
p.D1827N	SIDM01611	Endometrial Carcinoma	GDSC	RRFFLRCII	DEG_APCC_DBOX_1	0.0556
p.D1827N	ACH-000996	Endometrial/Uterine Cancer	CCLE	RRFFLRCII	DEG_APCC_DBOX_1	0.0556
p.P1801L	TCGA-BR-4368	STAD	TCGA	RRFFLRCII	DEG_APCC_DBOX_1	0.1111
p.E1818K	TCGA-EE-A29L	SKCM	TCGA	RRFFLRCII	DEG_APCC_DBOX_1	0.3056
p.R1807L	TCGA-EO-A22R	UCEC	TCGA	RRFFLRCII	DEG_APCC_DBOX_1	0.2778
p.E1804D	DO229025	LICA	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	0.6389
p.Q1818H	DO229006	LICA	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	0.3056
p.Q1822K	DO228451	MALY	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	0.1944
p.E1810K	DO222599	MELA	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	0.7022
p.E1810K	DO37835	SKCM	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	0.7022
p.P1809L	DO33091	PACA	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	0.7582
p.V1805I	DO46905	RECA	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	0.2222
p.P1808S	DO37442	SKCM	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	0.3056
p.Y1809N	DO229213	THCA	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	0.7059
p.D1806N	DO41542	UCEC	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	0.25
p.D1806N	DO42713	UCEC	ICGC	RRFFLRCII	DEG_APCC_DBOX_1	0.25
p.S1806P	SIDM00680	Colorectal Carcinoma	GDSC	RRFFLRCII	DEG_APCC_DBOX_1	0.25
p.S1806P	ACH-000957	Colon/Colorectal Cancer	CCLE	RRFFLRCII	DEG_APCC_DBOX_1	0.25
p.S1806P	LS-180	large_intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	0.25
p.E1802D	SIDM00534	Colorectal Carcinoma	GDSC	RRFFLRCII	DEG_APCC_DBOX_1	0.1389
p.E1802D	ACH-000986	Colon/Colorectal Cancer	CCLE	RRFFLRCII	DEG_APCC_DBOX_1	0.1389
p.E1802D	HT-115	large_intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	0.1389
p.G1820W	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	RRFFLRCII	DEG_APCC_DBOX_1	0.25
p.V1826I	ACH-000706	Lung Cancer	CCLE	RRFFLRCII	DEG_APCC_DBOX_1	0.0833
p.L1809I	ACH-000954	Endometrial/Uterine Cancer	CCLE	RRFFLRCII	DEG_APCC_DBOX_1	0.7174
p.M1824I	ACH-000985	Colon/Colorectal Cancer	CCLE	RRFFLRCII	DEG_APCC_DBOX_1	0.1389
p.S1805P	LS-180	large_intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	0.2222
p.E1801D	HT-115	large_intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	0.1111
p.L1826P	KM12	large_intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	0.0833
p.L1815P	KM12	large_intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	0.7582
p.L1825P	KM12	large_intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	0.1111
p.L1816P	KM12	large_intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	0.7582
p.L1802P	KM12	large_intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	0.1389
p.L1811P	KM12	large_intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	0.7582
p.S1799P	LS-180	large_intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	0.0556
p.L1812P	KM12	large_intestine	COSMIC	RRFFLRCII	DEG_APCC_DBOX_1	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRFFLRCII

Degron related mutations and impact score

Drug responses associated with DYSF mutations

All proteins holding degron of RRFFLRCII

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75923	Dysferlin	DEG_APCC_DBOX_1	1809:1817	RRFFLRCII	APC,CDC20,FZR1	0.5736	More...