DegronMD - Q13621(SLC12A1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A139T	TCGA-06-5416	GBM	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.2222
p.A139T	TCGA-D3-A8GL	SKCM	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.2222
p.A139T	DO10880	GBM	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.2222
p.A139T	DO50287	SKCM	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.2222
p.A139T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.2222
p.A139T	SIDM00656	Burkitt's Lymphoma	GDSC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.2222
p.A139T	SIDM01099	Neuroblastoma	GDSC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.2222
p.A139T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.2222
p.A139T	SIDM00641	Burkitt's Lymphoma	GDSC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.2222
p.T40N	TCGA-17-Z057	LUAD	TCGA	PPHY	ITCH	42:45	Mutation rewiring degron network	0.2778
p.S120N	TCGA-22-5483	LUSC	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation blocking phosphorylation signal	0.5833
p.S120N	DO26614	LUSC	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation blocking phosphorylation signal	0.5833
p.A36G	TCGA-34-2605	LUSC	TCGA	PPHY	ITCH	42:45	Mutation rewiring degron network	0.1667
p.A36G	DO26471	LUSC	ICGC	PPHY	ITCH	42:45	Mutation rewiring degron network	0.1667
p.L131M	TCGA-44-2656	LUAD	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.711
p.L131M	DO26052	LUAD	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.711
p.D52Y	TCGA-91-A4BC	LUAD	TCGA	PPHY	ITCH	42:45	Mutation rewiring degron network	0.1389
p.D52Y	DO45422	LUAD	ICGC	PPHY	ITCH	42:45	Mutation rewiring degron network	0.1389
p.E136K	TCGA-AP-A056	UCEC	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.3056
p.E136K	DO43971	UCEC	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.3056
p.D41G	TCGA-B5-A11E	UCEC	TCGA	PPHY	ITCH	42:45	Mutation rewiring degron network	0.3056
p.D41G	DO41644	UCEC	ICGC	PPHY	ITCH	42:45	Mutation rewiring degron network	0.3056
p.D37E	TCGA-CC-A3M9	LIHC	TCGA	PPHY	ITCH	42:45	Mutation rewiring degron network	0.1944
p.D37E	DO44946	LIHC	ICGC	PPHY	ITCH	42:45	Mutation rewiring degron network	0.1944
p.R128Q	TCGA-CV-6954	HNSC	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.7329
p.R128Q	DO15959	HNSC	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.7329
p.P124H	TCGA-CV-A45W	HNSC	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.25
p.P124H	TCGA-GS-A9TT	DLBC	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.25
p.P124H	DO219912	DLBC	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.25
p.P124H	DO52060	HNSC	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.25
p.T118I	TCGA-D3-A2JD	SKCM	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation blocking phosphorylation signal	0.5278
p.T118I	DO37543	SKCM	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation blocking phosphorylation signal	0.5278
p.S49Y	TCGA-E6-A1M0	UCEC	TCGA	PPHY	ITCH	42:45	Mutation rewiring degron network	0.2222
p.S49Y	DO222884	COCA	ICGC	PPHY	ITCH	42:45	Mutation rewiring degron network	0.2222
p.S49Y	DO43682	UCEC	ICGC	PPHY	ITCH	42:45	Mutation rewiring degron network	0.2222
p.T145I	TCGA-F1-6874	STAD	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.0556
p.T145I	DO38201	STAD	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.0556
p.L138I	DO52603	BOCA	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.25
p.T145A	DO233732	GACA	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.0556
p.G51W	DO229026	LICA	ICGC	PPHY	ITCH	42:45	Mutation rewiring degron network	0.1667
p.S120I	DO229038	LICA	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation blocking phosphorylation signal	0.5833
p.P124T	DO231155	LUSC	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.25
p.E133Q	DO51047	PRAD	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.5633
p.G123E	DO36556	READ	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.2222
p.Q137K	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.2778
p.Q137K	ACH-001680	Lymphoma	CCLE	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.2778
p.Q137K	U-698-M	haematopoietic and lymphoid tissue	COSMIC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.2778
p.S33N	SIDM00687	Gastric Carcinoma	GDSC	PPHY	ITCH	42:45	Mutation rewiring degron network	0.0833
p.S33N	ACH-000793	Gastric Cancer	CCLE	PPHY	ITCH	42:45	Mutation rewiring degron network	0.0833
p.S33N	KATOIII	stomach	COSMIC	PPHY	ITCH	42:45	Mutation rewiring degron network	0.0833
p.P124S	SIDM01146	Gastric Carcinoma	GDSC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.25
p.P124S	ACH-000932	Gastric Cancer	CCLE	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.25
p.P124S	NCI-SNU-1	stomach	COSMIC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.25
p.N127K	SIDM00153	T-Lymphoblastic Leukemia	GDSC	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.5806
p.N127K	ACH-000964	Leukemia	CCLE	NRPSLLEIH	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.5806
p.D38A	SIDM01320	Pancreatic Carcinoma	GDSC	PPHY	ITCH	42:45	Mutation rewiring degron network	0.2222
p.D38A	ACH-000468	Pancreatic Cancer	CCLE	PPHY	ITCH	42:45	Mutation rewiring degron network	0.2222
p.D38A	ACH-001277	Sarcoma	CCLE	PPHY	ITCH	42:45	Mutation rewiring degron network	0.2222
p.D38A	ACH-001607	Gallbladder Cancer	CCLE	PPHY	ITCH	42:45	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC12A1

UniProt ID: Q13621

Entrez ID: 6557

Protein name: Solute carrier family 12 member 1 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (Kidney-specific Na-K-Cl symporter)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC12A1 in