DegronMD

Uniprot ID: Q13621

Source protein: Solute carrier family 12 member 1

Source gene: SLC12A1

Class: DEG_APCC_DBOX_1

Location: 127:135

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9984

ASA_SCORE: 61.7556

COIL: 0.4318

CONS_SCORE: 0.355

DSS_SCORE: 0.4265

HELIX: 0.5453

FCONS_SCORE: 1.2798

RIG_SCORE: 0.777

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A139T	TCGA-06-5416	GBM	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	0.2222
p.A139T	TCGA-D3-A8GL	SKCM	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	0.2222
p.A139T	DO10880	GBM	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	0.2222
p.A139T	DO50287	SKCM	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	0.2222
p.A139T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	NRPSLLEIH	DEG_APCC_DBOX_1	0.2222
p.A139T	SIDM00656	Burkitt's Lymphoma	GDSC	NRPSLLEIH	DEG_APCC_DBOX_1	0.2222
p.A139T	SIDM01099	Neuroblastoma	GDSC	NRPSLLEIH	DEG_APCC_DBOX_1	0.2222
p.A139T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	NRPSLLEIH	DEG_APCC_DBOX_1	0.2222
p.A139T	SIDM00641	Burkitt's Lymphoma	GDSC	NRPSLLEIH	DEG_APCC_DBOX_1	0.2222
p.S120N	TCGA-22-5483	LUSC	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	0.5833
p.S120N	DO26614	LUSC	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	0.5833
p.L131M	TCGA-44-2656	LUAD	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	0.711
p.L131M	DO26052	LUAD	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	0.711
p.E136K	TCGA-AP-A056	UCEC	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	0.3056
p.E136K	DO43971	UCEC	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	0.3056
p.R128Q	TCGA-CV-6954	HNSC	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	0.7329
p.R128Q	DO15959	HNSC	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	0.7329
p.P124H	TCGA-CV-A45W	HNSC	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	0.25
p.P124H	TCGA-GS-A9TT	DLBC	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	0.25
p.P124H	DO219912	DLBC	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	0.25
p.P124H	DO52060	HNSC	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	0.25
p.T118I	TCGA-D3-A2JD	SKCM	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	0.5278
p.T118I	DO37543	SKCM	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	0.5278
p.T145I	TCGA-F1-6874	STAD	TCGA	NRPSLLEIH	DEG_APCC_DBOX_1	0.0556
p.T145I	DO38201	STAD	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	0.0556
p.L138I	DO52603	BOCA	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	0.25
p.T145A	DO233732	GACA	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	0.0556
p.S120I	DO229038	LICA	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	0.5833
p.P124T	DO231155	LUSC	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	0.25
p.E133Q	DO51047	PRAD	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	0.5633
p.G123E	DO36556	READ	ICGC	NRPSLLEIH	DEG_APCC_DBOX_1	0.2222
p.Q137K	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	NRPSLLEIH	DEG_APCC_DBOX_1	0.2778
p.Q137K	ACH-001680	Lymphoma	CCLE	NRPSLLEIH	DEG_APCC_DBOX_1	0.2778
p.Q137K	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	NRPSLLEIH	DEG_APCC_DBOX_1	0.2778
p.P124S	SIDM01146	Gastric Carcinoma	GDSC	NRPSLLEIH	DEG_APCC_DBOX_1	0.25
p.P124S	ACH-000932	Gastric Cancer	CCLE	NRPSLLEIH	DEG_APCC_DBOX_1	0.25
p.P124S	NCI-SNU-1	stomach	COSMIC	NRPSLLEIH	DEG_APCC_DBOX_1	0.25
p.N127K	SIDM00153	T-Lymphoblastic Leukemia	GDSC	NRPSLLEIH	DEG_APCC_DBOX_1	0.5806
p.N127K	ACH-000964	Leukemia	CCLE	NRPSLLEIH	DEG_APCC_DBOX_1	0.5806

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NRPSLLEIH

Degron related mutations and impact score

Drug responses associated with SLC12A1 mutations

All proteins holding degron of NRPSLLEIH

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13621	Solute carrier family 12 member 1	DEG_APCC_DBOX_1	127:135	NRPSLLEIH	APC,CDC20,FZR1	0.9984	More...