DegronMD - Q8NC67(NETO2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D405G	TCGA-BR-6706	STAD	TCGA	PPHY	ITCH	395:398	Mutation rewiring degron network	0.1389
p.D405G	DO38211	STAD	ICGC	PPHY	ITCH	395:398	Mutation rewiring degron network	0.1389
p.S456Y	TCGA-CA-6717	COAD	TCGA	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6009
p.P396L	TCGA-CG-4460	STAD	TCGA	PPHY	ITCH	395:398	Mutation altering degron motif	0.7582
p.P396L	TCGA-EE-A2MC	SKCM	TCGA	PPHY	ITCH	395:398	Mutation altering degron motif	0.7582
p.P396L	DO37559	SKCM	ICGC	PPHY	ITCH	395:398	Mutation altering degron motif	0.7582
p.P396L	DO38427	STAD	ICGC	PPHY	ITCH	395:398	Mutation altering degron motif	0.7582
p.G388R	TCGA-FV-A495	LIHC	TCGA	PPHY	ITCH	395:398	Mutation rewiring degron network	0.1389
p.G388R	DO44890	LIHC	ICGC	PPHY	ITCH	395:398	Mutation rewiring degron network	0.1389
p.S450R	TCGA-NC-A5HF	LUSC	TCGA	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6316
p.S449Y	DO8264	COAD	ICGC	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.3056
p.R455Q	DO234230	ESAD	ICGC	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.7329
p.A444D	DO229018	LICA	ICGC	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1667
p.P468T	DO229025	LICA	ICGC	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.0556
p.D407E	DO229045	LICA	ICGC	PPHY	ITCH	395:398	Mutation rewiring degron network	0.0833
p.D404Y	DO23580	LUAD	ICGC	PPHY	ITCH	395:398	Mutation rewiring degron network	0.1667
p.T387S	DO231043	LUSC	ICGC	PPHY	ITCH	395:398	Mutation rewiring degron network	0.1111
p.S443R	DO219185	LUSC	ICGC	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1389
p.N453Y	DO46897	RECA	ICGC	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.5948
p.P453S	DO218863	SKCA	ICGC	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6752
p.P453S	MCC13	skin	COSMIC	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6752
p.K386R	SIDM01233	Colorectal Carcinoma	GDSC	PPHY	ITCH	395:398	Mutation blocking ubiquitination signal	0.5278
p.K386R	ACH-000003		CCLE	PPHY	ITCH	395:398	Mutation blocking ubiquitination signal	0.5278
p.K386R	ACH-000009	Colon/Colorectal Cancer	CCLE	PPHY	ITCH	395:398	Mutation blocking ubiquitination signal	0.5278
p.K386R	C2BBe1	large intestine	COSMIC	PPHY	ITCH	395:398	Mutation blocking ubiquitination signal	0.5278
p.S456T	SIDM00656	Burkitt's Lymphoma	GDSC	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6005
p.S456T	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6005
p.S456T	SIDM01112	Osteosarcoma	GDSC	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6005
p.S456T	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6005
p.S456T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6005
p.S456T	SIDM00641	Burkitt's Lymphoma	GDSC	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6005
p.P460S	SIDM00007	Other Solid Cancers	GDSC	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.2778
p.P460S	ACH-001550	Skin Cancer	CCLE	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.2778
p.P460S	MCC13	skin	COSMIC	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.2778
p.S442L	SIDM00193	Colorectal Carcinoma	GDSC	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1111
p.S442L	ACH-000991	Colon/Colorectal Cancer	CCLE	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1111
p.S442L	SNU-81	large intestine	COSMIC	SRTNLSSME	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1111
p.G388E	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PPHY	ITCH	395:398	Mutation rewiring degron network	0.1389
p.G388E	ACH-001738	Leukemia	CCLE	PPHY	ITCH	395:398	Mutation rewiring degron network	0.1389
p.G388E	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PPHY	ITCH	395:398	Mutation rewiring degron network	0.1389
p.E391K	SIDM00567	Other Solid Cancers	GDSC	PPHY	ITCH	395:398	Mutation rewiring degron network	0.2222
p.E391K	ACH-000776	Brain Cancer	CCLE	PPHY	ITCH	395:398	Mutation rewiring degron network	0.2222
p.E391K	ONS-76	central nervous system	COSMIC	PPHY	ITCH	395:398	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NETO2

UniProt ID: Q8NC67

Entrez ID: 81831

Protein name: Neuropilin and tolloid-like protein 2 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NETO2 in