DegronMD

Uniprot ID: Q8NC67

Source protein: Neuropilin and tolloid-like protein 2

Source gene: NETO2

Class: DEG_APCC_DBOX_1

Location: 450:458

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5701

ASA_SCORE: 62.2111

COIL: 0.5384

CONS_SCORE: 0.4887

DSS_SCORE: 0.5326

HELIX: 0.0343

FCONS_SCORE: 1.2208

RIG_SCORE: 0.6796

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S456Y	TCGA-CA-6717	COAD	TCGA	SRTNLSSME	DEG_APCC_DBOX_1	0.6009
p.S450R	TCGA-NC-A5HF	LUSC	TCGA	SRTNLSSME	DEG_APCC_DBOX_1	0.6316
p.S449Y	DO8264	COAD	ICGC	SRTNLSSME	DEG_APCC_DBOX_1	0.3056
p.R455Q	DO234230	ESAD	ICGC	SRTNLSSME	DEG_APCC_DBOX_1	0.7329
p.A444D	DO229018	LICA	ICGC	SRTNLSSME	DEG_APCC_DBOX_1	0.1667
p.P468T	DO229025	LICA	ICGC	SRTNLSSME	DEG_APCC_DBOX_1	0.0556
p.S443R	DO219185	LUSC	ICGC	SRTNLSSME	DEG_APCC_DBOX_1	0.1389
p.N453Y	DO46897	RECA	ICGC	SRTNLSSME	DEG_APCC_DBOX_1	0.5948
p.P453S	DO218863	SKCA	ICGC	SRTNLSSME	DEG_APCC_DBOX_1	0.6752
p.P453S	MCC13	skin	COSMIC	SRTNLSSME	DEG_APCC_DBOX_1	0.6752
p.S456T	SIDM00656	Burkitt's Lymphoma	GDSC	SRTNLSSME	DEG_APCC_DBOX_1	0.6005
p.S456T	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	SRTNLSSME	DEG_APCC_DBOX_1	0.6005
p.S456T	SIDM01112	Osteosarcoma	GDSC	SRTNLSSME	DEG_APCC_DBOX_1	0.6005
p.S456T	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	SRTNLSSME	DEG_APCC_DBOX_1	0.6005
p.S456T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	SRTNLSSME	DEG_APCC_DBOX_1	0.6005
p.S456T	SIDM00641	Burkitt's Lymphoma	GDSC	SRTNLSSME	DEG_APCC_DBOX_1	0.6005
p.P460S	SIDM00007	Other Solid Cancers	GDSC	SRTNLSSME	DEG_APCC_DBOX_1	0.2778
p.P460S	ACH-001550	Skin Cancer	CCLE	SRTNLSSME	DEG_APCC_DBOX_1	0.2778
p.P460S	MCC13	skin	COSMIC	SRTNLSSME	DEG_APCC_DBOX_1	0.2778
p.S442L	SIDM00193	Colorectal Carcinoma	GDSC	SRTNLSSME	DEG_APCC_DBOX_1	0.1111
p.S442L	ACH-000991	Colon/Colorectal Cancer	CCLE	SRTNLSSME	DEG_APCC_DBOX_1	0.1111
p.S442L	SNU-81	large_intestine	COSMIC	SRTNLSSME	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NC67	Neuropilin and tolloid-like protein 2	DEG_APCC_DBOX_1	450:458	SRTNLSSME	APC,CDC20,FZR1	0.5701	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons