DegronMD - Q7Z4S6(KIF21A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1180V	TCGA-06-5416	GBM	TCGA	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.1944
p.T1187I	TCGA-55-1592	LUAD	TCGA	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation altering degron motif	0.7078
p.H178N	TCGA-AA-3977	COAD	TCGA	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation altering degron motif	0.7423
p.H178N	DO8730	COAD	ICGC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation altering degron motif	0.7423
p.A1548S	TCGA-AX-A2HC	UCEC	TCGA	PPHY	ITCH	1540:1543	Mutation rewiring degron network	0.1944
p.G1184D	TCGA-BR-4184	STAD	TCGA	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.3056
p.D180Y	TCGA-BS-A0UF	UCEC	TCGA	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation altering degron motif	0.7325
p.D180Y	TCGA-FD-A3B5	BLCA	TCGA	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation altering degron motif	0.7325
p.D180Y	DO714	BLCA	ICGC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation altering degron motif	0.7325
p.D180Y	DO41488	UCEC	ICGC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation altering degron motif	0.7325
p.E1539A	TCGA-CA-6717	COAD	TCGA	PPHY	ITCH	1540:1543	Mutation rewiring degron network	0.3056
p.S1181Y	TCGA-FI-A2D5	UCEC	TCGA	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.2222
p.P1541L	TCGA-FW-A3R5	SKCM	TCGA	PPHY	ITCH	1540:1543	Mutation altering degron motif	0.7582
p.H1542Y	TCGA-G9-6343	PRAD	TCGA	PPHY	ITCH	1540:1543	Mutation altering degron motif	0.6118
p.T182S	TCGA-HT-7689	LGG	TCGA	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.2778
p.T182S	DO22740	LGG	ICGC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.2778
p.I1195F	TCGA-IR-A3LH	CESC	TCGA	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.2222
p.E1194D	TCGA-IR-A3LH	CESC	TCGA	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.25
p.Q1552K	TCGA-KQ-A41N	BLCA	TCGA	PPHY	ITCH	1540:1543	Mutation rewiring degron network	0.0833
p.S173L	TCGA-WE-A8ZX	SKCM	TCGA	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.2778
p.S173L	DO51291	SKCM	ICGC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.2778
p.I1201T	DO1774	BRCA	ICGC	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.0556
p.I1175F	DO44381	CESC	ICGC	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.0556
p.R1187K	DO10373	COAD	ICGC	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation altering degron motif	0.7237
p.E1190V	DO222589	ESCA	ICGC	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation altering degron motif	0.7693
p.K1200E	DO13372	GBM	ICGC	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.0833
p.V190L	DO228945	LICA	ICGC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.0556
p.P1195T	DO229027	LICA	ICGC	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.2222
p.T1181K	DO229031	LICA	ICGC	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.2222
p.T1184N	DO229045	LICA	ICGC	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.3056
p.V1542L	DO26449	LUSC	ICGC	PPHY	ITCH	1540:1543	Mutation altering degron motif	0.6765
p.H178Y	DO220891	MELA	ICGC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation altering degron motif	0.6118
p.S181L	DO222749	MELA	ICGC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.3056
p.T1184I	DO29638	OV	ICGC	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.3056
p.V190I	DO35442	PACA	ICGC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.0556
p.P1198S	DO50284	SKCM	ICGC	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.1389
p.G189S	DO229257	THCA	ICGC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.0833
p.T1534S	DO229272	THCA	ICGC	PPHY	ITCH	1540:1543	Mutation rewiring degron network	0.1667
p.Q1535K	DO229221	THCA	ICGC	PPHY	ITCH	1540:1543	Mutation rewiring degron network	0.1944
p.S1199F	DO219585	THCA	ICGC	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.1111
p.K1189N	DO41235	UCEC	ICGC	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation altering degron motif	0.6918
p.R176K	SIDM00422	Hodgkin's Lymphoma	GDSC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation altering degron motif	0.6126
p.R176K	ACH-001203	Lymphoma	CCLE	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation altering degron motif	0.6126
p.R176K	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation altering degron motif	0.6126
p.S170N	SIDM00845	Burkitt's Lymphoma	GDSC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.1944
p.S170N	SIDM00461	Acute Myeloid Leukemia	GDSC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.1944
p.S170N	SIDM01519	Head and Neck Carcinoma	GDSC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.1944
p.S170N	ACH-000786	Lymphoma	CCLE	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.1944
p.S170N	ACH-000992	Head and Neck Cancer	CCLE	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.1944
p.D165Y	SIDM00796	Head and Neck Carcinoma	GDSC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.0556
p.D165Y	ACH-000740	Head and Neck Cancer	CCLE	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.0556
p.D165Y	A253	salivary gland	COSMIC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.0556
p.V188M	SIDM00878	Breast Carcinoma	GDSC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.1111
p.V188M	ACH-000930	Breast Cancer	CCLE	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.1111
p.V188M	HCC1569	breast	COSMIC	IRIHED	LIG_APCC_ABBA_1	175:180	Mutation rewiring degron network	0.1111
p.D1179E	SIDM00879	Breast Carcinoma	GDSC	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.1667
p.D1179E	ACH-000349	Breast Cancer	CCLE	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.1667
p.D1179E	HCC1500	breast	COSMIC	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.1667
p.V1532M	SIDM00937	Oral Cavity Carcinoma	GDSC	PPHY	ITCH	1540:1543	Mutation rewiring degron network	0.1111
p.V1532M	ACH-000832	Head and Neck Cancer	CCLE	PPHY	ITCH	1540:1543	Mutation rewiring degron network	0.1111
p.V1532M	CAL-27	upper aerodigestive tract	COSMIC	PPHY	ITCH	1540:1543	Mutation rewiring degron network	0.1111
p.H1543R	NCI-H630	large intestine	COSMIC	PPHY	ITCH	1540:1543	Mutation altering degron motif	0.8244
p.D1537E	SBC-1	lung	COSMIC	PPHY	ITCH	1540:1543	Mutation rewiring degron network	0.25
p.D1537E	huH-1	liver	COSMIC	PPHY	ITCH	1540:1543	Mutation rewiring degron network	0.25
p.D1537Y	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PPHY	ITCH	1540:1543	Mutation rewiring degron network	0.25
p.G1549V	SW756	cervix	COSMIC	PPHY	ITCH	1540:1543	Mutation rewiring degron network	0.1667
p.S1195L	SCH	stomach	COSMIC	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.2222
p.P1200A	H2369	pleura	COSMIC	PLTPVAE	DEG_SCF_FBW7_2	1185:1191	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF21A

UniProt ID: Q7Z4S6

Entrez ID: 55605

Protein name: Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF21A in