DegronMD

Uniprot ID: Q7Z4S6

Source protein: Kinesin-like protein KIF21A

Source gene: KIF21A

Class: DEG_SCF_FBW7_2

Location: 1185:1191

E3 ligase: FBXW7

DEGRON score: 0.986

ASA_SCORE: 77.3714

COIL: 0.8169

CONS_SCORE: 0.4262

DSS_SCORE: 0.6987

HELIX: 0.1374

FCONS_SCORE: 1.0512

RIG_SCORE: 0.6764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1180V	TCGA-06-5416	GBM	TCGA	PLTPVAE	DEG_SCF_FBW7_2	0.1944
p.T1187I	TCGA-55-1592	LUAD	TCGA	PLTPVAE	DEG_SCF_FBW7_2	0.7078
p.G1184D	TCGA-BR-4184	STAD	TCGA	PLTPVAE	DEG_SCF_FBW7_2	0.3056
p.S1181Y	TCGA-FI-A2D5	UCEC	TCGA	PLTPVAE	DEG_SCF_FBW7_2	0.2222
p.I1195F	TCGA-IR-A3LH	CESC	TCGA	PLTPVAE	DEG_SCF_FBW7_2	0.2222
p.E1194D	TCGA-IR-A3LH	CESC	TCGA	PLTPVAE	DEG_SCF_FBW7_2	0.25
p.I1201T	DO1774	BRCA	ICGC	PLTPVAE	DEG_SCF_FBW7_2	0.0556
p.I1175F	DO44381	CESC	ICGC	PLTPVAE	DEG_SCF_FBW7_2	0.0556
p.R1187K	DO10373	COAD	ICGC	PLTPVAE	DEG_SCF_FBW7_2	0.7237
p.E1190V	DO222589	ESCA	ICGC	PLTPVAE	DEG_SCF_FBW7_2	0.7693
p.K1200E	DO13372	GBM	ICGC	PLTPVAE	DEG_SCF_FBW7_2	0.0833
p.P1195T	DO229027	LICA	ICGC	PLTPVAE	DEG_SCF_FBW7_2	0.2222
p.T1181K	DO229031	LICA	ICGC	PLTPVAE	DEG_SCF_FBW7_2	0.2222
p.T1184N	DO229045	LICA	ICGC	PLTPVAE	DEG_SCF_FBW7_2	0.3056
p.T1184I	DO29638	OV	ICGC	PLTPVAE	DEG_SCF_FBW7_2	0.3056
p.P1198S	DO50284	SKCM	ICGC	PLTPVAE	DEG_SCF_FBW7_2	0.1389
p.S1199F	DO219585	THCA	ICGC	PLTPVAE	DEG_SCF_FBW7_2	0.1111
p.K1189N	DO41235	UCEC	ICGC	PLTPVAE	DEG_SCF_FBW7_2	0.6918
p.D1179E	SIDM00879	Breast Carcinoma	GDSC	PLTPVAE	DEG_SCF_FBW7_2	0.1667
p.D1179E	ACH-000349	Breast Cancer	CCLE	PLTPVAE	DEG_SCF_FBW7_2	0.1667
p.D1179E	HCC1500	breast	COSMIC	PLTPVAE	DEG_SCF_FBW7_2	0.1667
p.S1195L	SCH	stomach	COSMIC	PLTPVAE	DEG_SCF_FBW7_2	0.2222
p.P1200A	H2369	pleura	COSMIC	PLTPVAE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z4S6	Kinesin-like protein KIF21A	DEG_SCF_FBW7_2	1185:1191	PLTPVAE	FBXW7	0.986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons