DegronMD

Uniprot ID: Q7Z4S6

Source protein: Kinesin-like protein KIF21A

Source gene: KIF21A

Class: LIG_APCC_ABBA_1

Location: 175:180

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.507

ASA_SCORE: 43.2

COIL: 0.2567

CONS_SCORE: 0.6052

DSS_SCORE: 0.341

HELIX: 0.004

FCONS_SCORE: 1.2684

RIG_SCORE: 0.7599

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H178N	TCGA-AA-3977	COAD	TCGA	IRIHED	LIG_APCC_ABBA_1	0.7423
p.H178N	DO8730	COAD	ICGC	IRIHED	LIG_APCC_ABBA_1	0.7423
p.D180Y	TCGA-BS-A0UF	UCEC	TCGA	IRIHED	LIG_APCC_ABBA_1	0.7325
p.D180Y	TCGA-FD-A3B5	BLCA	TCGA	IRIHED	LIG_APCC_ABBA_1	0.7325
p.D180Y	DO714	BLCA	ICGC	IRIHED	LIG_APCC_ABBA_1	0.7325
p.D180Y	DO41488	UCEC	ICGC	IRIHED	LIG_APCC_ABBA_1	0.7325
p.T182S	TCGA-HT-7689	LGG	TCGA	IRIHED	LIG_APCC_ABBA_1	0.2778
p.T182S	DO22740	LGG	ICGC	IRIHED	LIG_APCC_ABBA_1	0.2778
p.S173L	TCGA-WE-A8ZX	SKCM	TCGA	IRIHED	LIG_APCC_ABBA_1	0.2778
p.S173L	DO51291	SKCM	ICGC	IRIHED	LIG_APCC_ABBA_1	0.2778
p.V190L	DO228945	LICA	ICGC	IRIHED	LIG_APCC_ABBA_1	0.0556
p.H178Y	DO220891	MELA	ICGC	IRIHED	LIG_APCC_ABBA_1	0.6118
p.S181L	DO222749	MELA	ICGC	IRIHED	LIG_APCC_ABBA_1	0.3056
p.V190I	DO35442	PACA	ICGC	IRIHED	LIG_APCC_ABBA_1	0.0556
p.G189S	DO229257	THCA	ICGC	IRIHED	LIG_APCC_ABBA_1	0.0833
p.R176K	SIDM00422	Hodgkin's Lymphoma	GDSC	IRIHED	LIG_APCC_ABBA_1	0.6126
p.R176K	ACH-001203	Lymphoma	CCLE	IRIHED	LIG_APCC_ABBA_1	0.6126
p.R176K	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	IRIHED	LIG_APCC_ABBA_1	0.6126
p.S170N	SIDM00845	Burkitt's Lymphoma	GDSC	IRIHED	LIG_APCC_ABBA_1	0.1944
p.S170N	SIDM00461	Acute Myeloid Leukemia	GDSC	IRIHED	LIG_APCC_ABBA_1	0.1944
p.S170N	SIDM01519	Head and Neck Carcinoma	GDSC	IRIHED	LIG_APCC_ABBA_1	0.1944
p.S170N	ACH-000786	Lymphoma	CCLE	IRIHED	LIG_APCC_ABBA_1	0.1944
p.S170N	ACH-000992	Head and Neck Cancer	CCLE	IRIHED	LIG_APCC_ABBA_1	0.1944
p.D165Y	SIDM00796	Head and Neck Carcinoma	GDSC	IRIHED	LIG_APCC_ABBA_1	0.0556
p.D165Y	ACH-000740	Head and Neck Cancer	CCLE	IRIHED	LIG_APCC_ABBA_1	0.0556
p.D165Y	A253	salivary_gland	COSMIC	IRIHED	LIG_APCC_ABBA_1	0.0556
p.V188M	SIDM00878	Breast Carcinoma	GDSC	IRIHED	LIG_APCC_ABBA_1	0.1111
p.V188M	ACH-000930	Breast Cancer	CCLE	IRIHED	LIG_APCC_ABBA_1	0.1111
p.V188M	HCC1569	breast	COSMIC	IRIHED	LIG_APCC_ABBA_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRIHED

Degron related mutations and impact score

Drug responses associated with KIF21A mutations

All proteins holding degron of IRIHED

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z4S6	Kinesin-like protein KIF21A	LIG_APCC_ABBA_1	175:180	IRIHED	APC,CDC20,FZR1	0.507	More...