DegronMD

Uniprot ID: Q7Z4S6

Source protein: Kinesin-like protein KIF21A

Source gene: KIF21A

Class: LIG_APCC_ABBA_1

Location: 175:180

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.507

ASA_SCORE: 43.2

COIL: 0.2567

CONS_SCORE: 0.6052

DSS_SCORE: 0.341

HELIX: 0.004

FCONS_SCORE: 1.2684

RIG_SCORE: 0.7599

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H178N	TCGA-AA-3977	COAD	TCGA	IRIHED	LIG_APCC_ABBA_1	0.7423
p.H178N	DO8730	COAD	ICGC	IRIHED	LIG_APCC_ABBA_1	0.7423
p.D180Y	TCGA-BS-A0UF	UCEC	TCGA	IRIHED	LIG_APCC_ABBA_1	0.7325
p.D180Y	TCGA-FD-A3B5	BLCA	TCGA	IRIHED	LIG_APCC_ABBA_1	0.7325
p.D180Y	DO714	BLCA	ICGC	IRIHED	LIG_APCC_ABBA_1	0.7325
p.D180Y	DO41488	UCEC	ICGC	IRIHED	LIG_APCC_ABBA_1	0.7325
p.R176K	SIDM00422	Hodgkin's Lymphoma	GDSC	IRIHED	LIG_APCC_ABBA_1	0.6126
p.R176K	ACH-001203	Lymphoma	CCLE	IRIHED	LIG_APCC_ABBA_1	0.6126
p.R176K	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	IRIHED	LIG_APCC_ABBA_1	0.6126
p.H178Y	DO220891	MELA	ICGC	IRIHED	LIG_APCC_ABBA_1	0.6118
p.S181L	DO222749	MELA	ICGC	IRIHED	LIG_APCC_ABBA_1	0.3056
p.T182S	TCGA-HT-7689	LGG	TCGA	IRIHED	LIG_APCC_ABBA_1	0.2778
p.T182S	DO22740	LGG	ICGC	IRIHED	LIG_APCC_ABBA_1	0.2778
p.S173L	TCGA-WE-A8ZX	SKCM	TCGA	IRIHED	LIG_APCC_ABBA_1	0.2778
p.S173L	DO51291	SKCM	ICGC	IRIHED	LIG_APCC_ABBA_1	0.2778
p.S170N	SIDM00845	Burkitt's Lymphoma	GDSC	IRIHED	LIG_APCC_ABBA_1	0.1944
p.S170N	SIDM00461	Acute Myeloid Leukemia	GDSC	IRIHED	LIG_APCC_ABBA_1	0.1944
p.S170N	SIDM01519	Head and Neck Carcinoma	GDSC	IRIHED	LIG_APCC_ABBA_1	0.1944
p.S170N	ACH-000786	Lymphoma	CCLE	IRIHED	LIG_APCC_ABBA_1	0.1944
p.S170N	ACH-000992	Head and Neck Cancer	CCLE	IRIHED	LIG_APCC_ABBA_1	0.1944
p.V188M	SIDM00878	Breast Carcinoma	GDSC	IRIHED	LIG_APCC_ABBA_1	0.1111
p.V188M	ACH-000930	Breast Cancer	CCLE	IRIHED	LIG_APCC_ABBA_1	0.1111
p.V188M	HCC1569	breast	COSMIC	IRIHED	LIG_APCC_ABBA_1	0.1111
p.G189S	DO229257	THCA	ICGC	IRIHED	LIG_APCC_ABBA_1	0.0833
p.V190L	DO228945	LICA	ICGC	IRIHED	LIG_APCC_ABBA_1	0.0556

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Drug responses associated with KIF21A mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of IRIHED

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z4S6	Kinesin-like protein KIF21A	LIG_APCC_ABBA_1	175:180	IRIHED	APC,CDC20,FZR1	0.507	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRIHED

Degron related mutations and impact score

Drug responses associated with KIF21A mutations

All proteins holding degron of IRIHED