DegronMD - Q8NFH8(REPS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A435D	TCGA-09-1675	OV	TCGA	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation rewiring degron network	0.0833
p.V556L	TCGA-24-2262	OV	TCGA	DVLYSQPP	CBL_PTK	555:562	Mutation altering degron motif	0.5654
p.R205M	TCGA-28-5211	GBM	TCGA	PPHY	ITCH	200:203	Mutation rewiring degron network	0.2778
p.A552P	TCGA-55-1595	LUAD	TCGA	DVLYSQPP	CBL_PTK	555:562	Mutation rewiring degron network	0.25
p.S550N	TCGA-A5-A0G2	UCEC	TCGA	DVLYSQPP	CBL_PTK	555:562	Mutation rewiring degron network	0.1944
p.R456I	TCGA-A5-A2K5	UCEC	TCGA	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation rewiring degron network	0.1667
p.K554N	TCGA-AX-A063	UCEC	TCGA	DVLYSQPP	CBL_PTK	555:562	Mutation rewiring degron network	0.3056
p.S452I	TCGA-B5-A11E	UCEC	TCGA	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation rewiring degron network	0.2778
p.S459C	TCGA-CZ-4865	KIRC	TCGA	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation blocking phosphorylation signal	0.5278
p.G211C	TCGA-D3-A1Q1	SKCM	TCGA	PPHY	ITCH	200:203	Mutation rewiring degron network	0.1111
p.Q545H	TCGA-DF-A2KN	UCEC	TCGA	DVLYSQPP	CBL_PTK	555:562	Mutation rewiring degron network	0.0556
p.D439A	TCGA-EO-A22U	UCEC	TCGA	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation rewiring degron network	0.1944
p.E442Q	TCGA-G2-AA3B	BLCA	TCGA	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation rewiring degron network	0.2778
p.S559F	TCGA-GN-A266	SKCM	TCGA	DVLYSQPP	CBL_PTK	555:562	Mutation altering degron motif	0.7982
p.R456K	TCGA-JX-A3Q0	CESC	TCGA	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation rewiring degron network	0.1667
p.H202P	TCGA-KB-A93H	STAD	TCGA	PPHY	ITCH	200:203	Mutation altering degron motif	0.6583
p.S559Y	TCGA-ND-A4WC	UCS	TCGA	DVLYSQPP	CBL_PTK	555:562	Mutation altering degron motif	0.712
p.R455K	DO51607	CESC	ICGC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation rewiring degron network	0.1944
p.S460A	DO6320	CESC	ICGC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation rewiring degron network	0.0556
p.R454C	DO9002	COAD	ICGC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation substituting flanking lysine	0.3333
p.R454C	DO222762	COCA	ICGC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation substituting flanking lysine	0.3333
p.R454C	DO218861	SKCA	ICGC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation substituting flanking lysine	0.3333
p.R454C	DO41542	UCEC	ICGC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation substituting flanking lysine	0.3333
p.R454C	DO41488	UCEC	ICGC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation substituting flanking lysine	0.3333
p.D190G	DO8842	COAD	ICGC	PPHY	ITCH	200:203	Mutation rewiring degron network	0.0556
p.D190H	DO14447	HNSC	ICGC	PPHY	ITCH	200:203	Mutation rewiring degron network	0.0556
p.S458C	DO16741	KIRC	ICGC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation rewiring degron network	0.1111
p.L446F	DO229035	LICA	ICGC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation altering degron motif	0.6981
p.G213S	DO23729	LUAD	ICGC	PPHY	ITCH	200:203	Mutation blocking phosphorylation signal	0.5
p.S451N	DO51549	PACA	ICGC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation rewiring degron network	0.3056
p.T457S	DO50293	SKCM	ICGC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation rewiring degron network	0.1389
p.H440Y	DO47480	SKCM	ICGC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation rewiring degron network	0.2222
p.H205Y	DO47331	SKCM	ICGC	PPHY	ITCH	200:203	Mutation rewiring degron network	0.2778
p.E199K	DO219456	SKCM	ICGC	PPHY	ITCH	200:203	Mutation blocking phosphorylation signal	0.75
p.R210Q	DO38479	STAD	ICGC	PPHY	ITCH	200:203	Mutation rewiring degron network	0.1389
p.G193E	DO42280	UCEC	ICGC	PPHY	ITCH	200:203	Mutation rewiring degron network	0.1389
p.Q441H	DO43082	UCEC	ICGC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation rewiring degron network	0.25
p.I207V	DO52402	UCEC	ICGC	PPHY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.S451I	DO41644	UCEC	ICGC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation rewiring degron network	0.3056
p.K211N	DO41542	UCEC	ICGC	PPHY	ITCH	200:203	Mutation rewiring degron network	0.1111
p.R455I	DO41379	UCEC	ICGC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation rewiring degron network	0.1944
p.P207S	SIDM00845	Burkitt's Lymphoma	GDSC	PPHY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.P207S	SIDM00461	Acute Myeloid Leukemia	GDSC	PPHY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.P207S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPHY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.P207S	SIDM01519	Head and Neck Carcinoma	GDSC	PPHY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.P207S	ACH-000786	Lymphoma	CCLE	PPHY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.P207S	ACH-000992	Head and Neck Cancer	CCLE	PPHY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.P207S	ACH-001067	Brain Cancer	CCLE	PPHY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.P207S	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PPHY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.P207S	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPHY	ITCH	200:203	Mutation rewiring degron network	0.2222
p.V206M	SIDM00190	Melanoma	GDSC	PPHY	ITCH	200:203	Mutation rewiring degron network	0.25
p.V206M	ACH-002097	Skin Cancer	CCLE	PPHY	ITCH	200:203	Mutation rewiring degron network	0.25
p.V206M	CP66-MEL	skin	COSMIC	PPHY	ITCH	200:203	Mutation rewiring degron network	0.25
p.K448N	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation altering degron motif	0.5806
p.K448N	JSC-1	haematopoietic and lymphoid tissue	COSMIC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation altering degron motif	0.5806
p.A455T	SIDM00901	Endometrial Carcinoma	GDSC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation rewiring degron network	0.1944
p.A455T	AN3-CA	endometrium	COSMIC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation rewiring degron network	0.1944
p.A454T	AN3-CA	endometrium	COSMIC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation substituting flanking lysine	0.3333
p.P206S	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPHY	ITCH	200:203	Mutation rewiring degron network	0.25
p.P206S	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PPHY	ITCH	200:203	Mutation rewiring degron network	0.25
p.K447N	JSC-1	haematopoietic and lymphoid tissue	COSMIC	PATPKDS	DEG_SCF_FBW7_1	444:450	Mutation altering degron motif	0.6918
p.V205M	CP66-MEL	skin	COSMIC	PPHY	ITCH	200:203	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

REPS2

UniProt ID: Q8NFH8

Entrez ID: 9185

Protein name: RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for REPS2 in