DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DVLYSQPP
Uniprot ID:
Q8NFH8
Source protein:
RalBP1-associated Eps domain-containing protein 2
Source gene:
REPS2
Class:
CBL_PTK
Location:
555:562
E3 ligase:
CBL
DEGRON score:
0.5946
ASA_SCORE:
91.6
COIL:
0.836
CONS_SCORE:
0.3088
DSS_SCORE:
0.6866
HELIX:
0.136
FCONS_SCORE:
0.8755
RIG_SCORE:
0.6378
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V556L
TCGA-24-2262
OV
TCGA
DVLYSQPP
CBL_PTK
0.5654
p.A552P
TCGA-55-1595
LUAD
TCGA
DVLYSQPP
CBL_PTK
0.25
p.S550N
TCGA-A5-A0G2
UCEC
TCGA
DVLYSQPP
CBL_PTK
0.1944
p.K554N
TCGA-AX-A063
UCEC
TCGA
DVLYSQPP
CBL_PTK
0.3056
p.Q545H
TCGA-DF-A2KN
UCEC
TCGA
DVLYSQPP
CBL_PTK
0.0556
p.S559F
TCGA-GN-A266
SKCM
TCGA
DVLYSQPP
CBL_PTK
0.7982
p.S559Y
TCGA-ND-A4WC
UCS
TCGA
DVLYSQPP
CBL_PTK
0.712
Drug responses associated with REPS2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DVLYSQPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NFH8
RalBP1-associated Eps domain-containing protein 2
CBL_PTK
555:562
DVLYSQPP
CBL
0.5946
More...
