DegronMD

Uniprot ID: Q8NFH8

Source protein: RalBP1-associated Eps domain-containing protein 2

Source gene: REPS2

Class: DEG_SCF_FBW7_1

Location: 444:450

E3 ligase: FBXW7

DEGRON score: 0.9559

ASA_SCORE: 82.1571

COIL: 0.9214

CONS_SCORE: 0.2587

DSS_SCORE: 0.7008

HELIX: 0.0551

FCONS_SCORE: 0.7348

RIG_SCORE: 0.6261

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A435D	TCGA-09-1675	OV	TCGA	PATPKDS	DEG_SCF_FBW7_1	0.0833
p.R456I	TCGA-A5-A2K5	UCEC	TCGA	PATPKDS	DEG_SCF_FBW7_1	0.1667
p.S452I	TCGA-B5-A11E	UCEC	TCGA	PATPKDS	DEG_SCF_FBW7_1	0.2778
p.S459C	TCGA-CZ-4865	KIRC	TCGA	PATPKDS	DEG_SCF_FBW7_1	0.5278
p.D439A	TCGA-EO-A22U	UCEC	TCGA	PATPKDS	DEG_SCF_FBW7_1	0.1944
p.E442Q	TCGA-G2-AA3B	BLCA	TCGA	PATPKDS	DEG_SCF_FBW7_1	0.2778
p.R456K	TCGA-JX-A3Q0	CESC	TCGA	PATPKDS	DEG_SCF_FBW7_1	0.1667
p.R455K	DO51607	CESC	ICGC	PATPKDS	DEG_SCF_FBW7_1	0.1944
p.S460A	DO6320	CESC	ICGC	PATPKDS	DEG_SCF_FBW7_1	0.0556
p.R454C	DO9002	COAD	ICGC	PATPKDS	DEG_SCF_FBW7_1	0.3333
p.R454C	DO222762	COCA	ICGC	PATPKDS	DEG_SCF_FBW7_1	0.3333
p.R454C	DO218861	SKCA	ICGC	PATPKDS	DEG_SCF_FBW7_1	0.3333
p.R454C	DO41542	UCEC	ICGC	PATPKDS	DEG_SCF_FBW7_1	0.3333
p.R454C	DO41488	UCEC	ICGC	PATPKDS	DEG_SCF_FBW7_1	0.3333
p.S458C	DO16741	KIRC	ICGC	PATPKDS	DEG_SCF_FBW7_1	0.1111
p.L446F	DO229035	LICA	ICGC	PATPKDS	DEG_SCF_FBW7_1	0.6981
p.S451N	DO51549	PACA	ICGC	PATPKDS	DEG_SCF_FBW7_1	0.3056
p.T457S	DO50293	SKCM	ICGC	PATPKDS	DEG_SCF_FBW7_1	0.1389
p.H440Y	DO47480	SKCM	ICGC	PATPKDS	DEG_SCF_FBW7_1	0.2222
p.Q441H	DO43082	UCEC	ICGC	PATPKDS	DEG_SCF_FBW7_1	0.25
p.S451I	DO41644	UCEC	ICGC	PATPKDS	DEG_SCF_FBW7_1	0.3056
p.R455I	DO41379	UCEC	ICGC	PATPKDS	DEG_SCF_FBW7_1	0.1944
p.K448N	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	PATPKDS	DEG_SCF_FBW7_1	0.5806
p.K448N	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	PATPKDS	DEG_SCF_FBW7_1	0.5806
p.A455T	SIDM00901	Endometrial Carcinoma	GDSC	PATPKDS	DEG_SCF_FBW7_1	0.1944
p.A455T	AN3-CA	endometrium	COSMIC	PATPKDS	DEG_SCF_FBW7_1	0.1944
p.A454T	AN3-CA	endometrium	COSMIC	PATPKDS	DEG_SCF_FBW7_1	0.3333
p.K447N	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	PATPKDS	DEG_SCF_FBW7_1	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFH8	RalBP1-associated Eps domain-containing protein 2	DEG_SCF_FBW7_1	444:450	PATPKDS	FBXW7	0.9559	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATPKDS

Degron related mutations and impact score

Drug responses associated with REPS2 mutations

All proteins holding degron of PATPKDS