DegronMD

Uniprot ID: Q6ZRV2

Source protein: Protein FAM83H

Source gene: FAM83H

Class: ITCH

Location: 21:24

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9628

ASA_SCORE: 65.625

COIL: 0.8975

CONS_SCORE: 0.9304

DSS_SCORE: 0.3187

HELIX: 0.0725

FCONS_SCORE: 1.0473

RIG_SCORE: 0.7508

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G18E	TCGA-56-7221	LUSC	TCGA	PPHY	ITCH	0.25
p.G18E	DO26689	LUSC	ICGC	PPHY	ITCH	0.25
p.D12G	TCGA-AA-3947	COAD	TCGA	PPHY	ITCH	0.0833
p.D12G	DO8192	COAD	ICGC	PPHY	ITCH	0.0833
p.R29C	TCGA-CC-5262	LIHC	TCGA	PPHY	ITCH	0.1944
p.R29C	DO50973	LICA	ICGC	PPHY	ITCH	0.1944
p.R29C	DO22953	LIHC	ICGC	PPHY	ITCH	0.1944
p.A34E	TCGA-DM-A1D8	COAD	TCGA	PPHY	ITCH	0.0556
p.A34E	DO8914	COAD	ICGC	PPHY	ITCH	0.0556
p.P21A	TCGA-EE-A20B	SKCM	TCGA	PPHY	ITCH	0.7503
p.P21A	DO37547	SKCM	ICGC	PPHY	ITCH	0.7503
p.A31V	DO222874	COCA	ICGC	PPHY	ITCH	0.1389
p.P14L	SIDM00821	Kidney Carcinoma	GDSC	PPHY	ITCH	0.1389
p.P14L	ACH-002187	Kidney Cancer	CCLE	PPHY	ITCH	0.1389
p.P14L	RCC-AB	kidney	COSMIC	PPHY	ITCH	0.1389
p.A34T	ACH-000836	Head and Neck Cancer	CCLE	PPHY	ITCH	0.0556
p.K25E	ACH-001061	Colon/Colorectal Cancer	CCLE	PPHY	ITCH	0.3056

Drug responses associated with FAM83H mutations

All proteins holding degron of PPHY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15156	Zinc finger and BTB domain-containing protein 7B	ITCH	468:471	PPHY	ITCH,NEDD4	0.632	More...
O75081	Protein CBFA2T3	ITCH	339:342	PPHY	ITCH,NEDD4	0.9949	More...
O75618	Death effector domain-containing protein	ITCH	146:149	PPHY	ITCH,NEDD4	0.9035	More...
O75923	Dysferlin	ITCH	194:197	PPHY	ITCH,NEDD4	0.877	More...
O94855	Protein transport protein Sec24D	ITCH	23:26	PPHY	ITCH,NEDD4	0.9579	More...
P14866	Heterogeneous nuclear ribonucleoprotein L	ITCH	337:340	PPHY	ITCH,NEDD4	0.9935	More...
P56693	Transcription factor SOX-10	ITCH	366:369	PPHY	ITCH,NEDD4	0.9951	More...
P62072	Mitochondrial import inner membrane translocase subunit Tim10	ITCH	35:38	PPHY	ITCH,NEDD4	0.6439	More...
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	ITCH	1704:1707	PPHY	ITCH,NEDD4	0.6355	More...
Q13227	G protein pathway suppressor 2	ITCH	194:197	PPHY	ITCH,NEDD4	0.9693	More...
Q13621	Solute carrier family 12 member 1	ITCH	42:45	PPHY	ITCH,NEDD4	0.9792	More...
Q6W2J9	BCL-6 corepressor	ITCH	249:252	PPHY	ITCH,NEDD4	0.7281	More...
Q6ZRV2	Protein FAM83H	ITCH	21:24	PPHY	ITCH,NEDD4	0.9628	More...
Q7Z4S6	Kinesin-like protein KIF21A	ITCH	1540:1543	PPHY	ITCH,NEDD4	0.7904	More...
Q86Y56	Dynein axonemal assembly factor 5	ITCH	335:338	PPHY	ITCH,NEDD4	0.6455	More...
Q8NC67	Neuropilin and tolloid-like protein 2	ITCH	395:398	PPHY	ITCH,NEDD4	0.9529	More...
Q8NEA6	Zinc finger protein GLIS3	ITCH	680:683	PPHY	ITCH,NEDD4	0.969	More...
Q8NFH8	RalBP1-associated Eps domain-containing protein 2	ITCH	200:203	PPHY	ITCH,NEDD4	0.9985	More...
Q9NZB2	Constitutive coactivator of PPAR-gamma-like protein 1	ITCH	339:342	PPHY	ITCH,NEDD4	0.7758	More...
Q9Y2G1	Myelin regulatory factor	ITCH	195:198	PPHY	ITCH,NEDD4	0.9944	More...
Q9Y2K2	Serine/threonine-protein kinase SIK3	ITCH	939:942	PPHY	ITCH,NEDD4	0.9973	More...
Q8TF68	Zinc finger protein 384	ITCH	46:49	PPHY	ITCH,NEDD4	0.9991	More...
Q96A35	39S ribosomal protein L24, mitochondrial	ITCH	16:19	PPHY	ITCH,NEDD4	0.837	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPHY

Degron related mutations and impact score

Drug responses associated with FAM83H mutations

All proteins holding degron of PPHY