DegronMD - Q9Y2K2(SIK3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A768T	TCGA-22-1011	LUSC	TCGA	AASSS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.2778
p.S770Y	TCGA-36-2545	OV	TCGA	AASSS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.2222
p.S770Y	DO28015	OV	ICGC	AASSS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.2222
p.M759K	TCGA-A5-A0G1	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.25
p.M759K	DO42472	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.25
p.K578R	TCGA-A6-6653	COAD	TCGA	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.2222
p.G769V	TCGA-A8-A09W	BRCA	TCGA	AASSS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.25
p.Q949R	TCGA-AX-A2HJ	UCEC	TCGA	PPHY	ITCH	939:942	Mutation rewiring degron network	0.1389
p.Q949R	TCGA-AX-A2HJ	UCEC	TCGA	PPDY	ITCH	956:959	Mutation rewiring degron network	0.1389
p.R940K	TCGA-BG-A0MS	UCEC	TCGA	PPHY	ITCH	939:942	Mutation altering degron motif	0.7237
p.P764S	TCGA-BR-7851	STAD	TCGA	AASSS	DEG_SPOP_SBC_1	762:766	Mutation altering degron motif	0.6752
p.P764S	DO38711	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	762:766	Mutation altering degron motif	0.6752
p.R773C	TCGA-CN-5369	HNSC	TCGA	AASSS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.1389
p.R773C	TCGA-FI-A2D0	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.1389
p.R773C	TCGA-VQ-AA6D	STAD	TCGA	AASSS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.1389
p.E598D	TCGA-DU-6392	LGG	TCGA	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0833
p.Q599H	TCGA-EO-A22R	UCEC	TCGA	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0556
p.I590M	TCGA-EQ-A4SO	STAD	TCGA	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.3056
p.Q954H	TCGA-F5-6814	READ	TCGA	PPDY	ITCH	956:959	Mutation rewiring degron network	0.2778
p.Q946R	TCGA-FI-A2D5	UCEC	TCGA	PPHY	ITCH	939:942	Mutation rewiring degron network	0.2222
p.Q946R	TCGA-FI-A2D5	UCEC	TCGA	PPDY	ITCH	956:959	Mutation rewiring degron network	0.0556
p.Q946R	TCGA-WS-AB45	COAD	TCGA	PPHY	ITCH	939:942	Mutation rewiring degron network	0.2222
p.Q946R	TCGA-WS-AB45	COAD	TCGA	PPDY	ITCH	956:959	Mutation rewiring degron network	0.0556
p.P930S	TCGA-HC-8266	PRAD	TCGA	PPHY	ITCH	939:942	Mutation rewiring degron network	0.0833
p.A572V	TCGA-OR-A5LB	ACC	TCGA	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0556
p.R962K	TCGA-ZN-A9VU	MESO	TCGA	PPDY	ITCH	956:959	Mutation rewiring degron network	0.25
p.Q944R	DO51734	COAD	ICGC	PPHY	ITCH	939:942	Mutation rewiring degron network	0.2778
p.Q944R	DO41331	UCEC	ICGC	PPHY	ITCH	939:942	Mutation rewiring degron network	0.2778
p.P594H	DO227646	COCA	ICGC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.1944
p.R767W	DO233699	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.3056
p.H596R	DO233823	GACA	ICGC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.1389
p.Q769E	DO14393	HNSC	ICGC	AASSS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.25
p.H963Y	DO52316	LIHC	ICGC	PPDY	ITCH	956:959	Mutation rewiring degron network	0.2222
p.A573S	DO25797	LUAD	ICGC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0833
p.Q952H	DO36556	READ	ICGC	PPHY	ITCH	939:942	Mutation rewiring degron network	0.0556
p.Q952H	DO36556	READ	ICGC	PPDY	ITCH	956:959	Mutation rewiring degron network	0.2222
p.A762V	DO37819	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	762:766	Mutation altering degron motif	0.5825
p.P941L	DO219472	SKCM	ICGC	PPHY	ITCH	939:942	Mutation altering degron motif	0.7582
p.R581Q	DO48174	UCEC	ICGC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.3056
p.P577L	DO52399	UCEC	ICGC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.1944
p.G594R	SIDM00962	Chronic Myelogenous Leukemia	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.1944
p.G594R	BV-173	haematopoietic and lymphoid tissue	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.1944
p.P587S	SIDM00845	Burkitt's Lymphoma	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation altering degron motif	0.6752
p.R589C	SIDM00525	Osteosarcoma	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation altering degron motif	0.8301
p.R589C	SIDM00393	Gastric Carcinoma	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation altering degron motif	0.8301
p.R589C	MG-63	bone	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation altering degron motif	0.8301
p.R589C	SK-GT-2	stomach	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation altering degron motif	0.8301
p.P573L	SIDM00007	Other Solid Cancers	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0833
p.P573L	MCC13	skin	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0833
p.P573S	SIDM00007	Other Solid Cancers	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0833
p.P573S	MCC13	skin	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0833
p.R591W	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation blocking phosphorylation signal	0.7222
p.R591W	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation blocking phosphorylation signal	0.7222
p.M752T	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.0556
p.M752T	NCI-H1563	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.0556
p.P577R	SIDM00333	Endometrial Carcinoma	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.1944
p.P577R	MFE-319	endometrium	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.1944
p.R589H	SIDM00596	Endometrial Carcinoma	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation altering degron motif	0.8244
p.R589H	ACH-000941	Endometrial/Uterine Cancer	CCLE	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation altering degron motif	0.8244
p.R589H	ACH-000954	Endometrial/Uterine Cancer	CCLE	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation altering degron motif	0.8244
p.R589H	ACH-001517	Endometrial/Uterine Cancer	CCLE	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation altering degron motif	0.8244
p.R589H	HEC-1	endometrium	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation altering degron motif	0.8244
p.V598A	SIDM00498	Colorectal Carcinoma	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0833
p.V598A	SNU-C5	large intestine	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0833
p.V575F	SIDM01009	Neuroblastoma	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.1389
p.V575F	KELLY	autonomic ganglia	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.1389
p.P939L	SIDM01617	Endometrial Carcinoma	GDSC	PPHY	ITCH	939:942	Mutation altering degron motif	0.7582
p.A776S	SIDM01739	Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.0556
p.A776S	ACH-000297	Lung Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.0556
p.Q946K	ACH-000952	Prostate Cancer	CCLE	PPHY	ITCH	939:942	Mutation rewiring degron network	0.2222
p.Q946K	ACH-000952	Prostate Cancer	CCLE	PPDY	ITCH	956:959	Mutation rewiring degron network	0.0556
p.N587S	ACH-000992	Head and Neck Cancer	CCLE	PAVTPVDE	DEG_SCF_FBW7_2	582:589	Mutation altering degron motif	0.7069
p.A967V	ACH-000999	Colon/Colorectal Cancer	CCLE	PPDY	ITCH	956:959	Mutation rewiring degron network	0.1111
p.A967V	SNU-1040	large intestine	COSMIC	PPDY	ITCH	956:959	Mutation rewiring degron network	0.1111
p.S969N	ACH-002084	Skin Cancer	CCLE	PPDY	ITCH	956:959	Mutation rewiring degron network	0.0556
p.S969N	ACH-002162	Skin Cancer	CCLE	PPDY	ITCH	956:959	Mutation rewiring degron network	0.0556
p.S969N	ACH-002290	Leukemia	CCLE	PPDY	ITCH	956:959	Mutation rewiring degron network	0.0556
p.S969N	MMAC-SF	skin	COSMIC	PPDY	ITCH	956:959	Mutation rewiring degron network	0.0556
p.S969N	NKM-1	haematopoietic and lymphoid tissue	COSMIC	PPDY	ITCH	956:959	Mutation rewiring degron network	0.0556
p.V965A	EN	endometrium	COSMIC	PPDY	ITCH	956:959	Mutation rewiring degron network	0.1667
p.L958P	NCI-H1915	lung	COSMIC	PPDY	ITCH	956:959	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SIK3

UniProt ID: Q9Y2K2

Entrez ID: 23387

Protein name: Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SIK3 in