DegronMD

Uniprot ID: Q9Y2K2

Source protein: Serine/threonine-protein kinase SIK3

Source gene: SIK3

Class: DEG_SCF_FBW7_2

Location: 582:589

E3 ligase: FBXW7

DEGRON score: 0.9804

ASA_SCORE: 92.1875

COIL: 0.9305

CONS_SCORE: 0.4094

DSS_SCORE: 0.6982

HELIX: 0.0375

FCONS_SCORE: 1.0345

RIG_SCORE: 0.6832

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K578R	TCGA-A6-6653	COAD	TCGA	PAVTPVDE	DEG_SCF_FBW7_2	0.2222
p.E598D	TCGA-DU-6392	LGG	TCGA	PAVTPVDE	DEG_SCF_FBW7_2	0.0833
p.Q599H	TCGA-EO-A22R	UCEC	TCGA	PAVTPVDE	DEG_SCF_FBW7_2	0.0556
p.I590M	TCGA-EQ-A4SO	STAD	TCGA	PAVTPVDE	DEG_SCF_FBW7_2	0.3056
p.A572V	TCGA-OR-A5LB	ACC	TCGA	PAVTPVDE	DEG_SCF_FBW7_2	0.0556
p.P594H	DO227646	COCA	ICGC	PAVTPVDE	DEG_SCF_FBW7_2	0.1944
p.H596R	DO233823	GACA	ICGC	PAVTPVDE	DEG_SCF_FBW7_2	0.1389
p.A573S	DO25797	LUAD	ICGC	PAVTPVDE	DEG_SCF_FBW7_2	0.0833
p.R581Q	DO48174	UCEC	ICGC	PAVTPVDE	DEG_SCF_FBW7_2	0.3056
p.P577L	DO52399	UCEC	ICGC	PAVTPVDE	DEG_SCF_FBW7_2	0.1944
p.G594R	SIDM00962	Chronic Myelogenous Leukemia	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	0.1944
p.G594R	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	0.1944
p.P587S	SIDM00845	Burkitt's Lymphoma	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	0.6752
p.R589C	SIDM00525	Osteosarcoma	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	0.8301
p.R589C	SIDM00393	Gastric Carcinoma	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	0.8301
p.R589C	MG-63	bone	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	0.8301
p.R589C	SK-GT-2	stomach	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	0.8301
p.P573L	SIDM00007	Other Solid Cancers	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	0.0833
p.P573L	MCC13	skin	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	0.0833
p.P573S	SIDM00007	Other Solid Cancers	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	0.0833
p.P573S	MCC13	skin	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	0.0833
p.R591W	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	0.7222
p.R591W	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	0.7222
p.P577R	SIDM00333	Endometrial Carcinoma	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	0.1944
p.P577R	MFE-319	endometrium	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	0.1944
p.R589H	SIDM00596	Endometrial Carcinoma	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	0.8244
p.R589H	ACH-000941	Endometrial/Uterine Cancer	CCLE	PAVTPVDE	DEG_SCF_FBW7_2	0.8244
p.R589H	ACH-000954	Endometrial/Uterine Cancer	CCLE	PAVTPVDE	DEG_SCF_FBW7_2	0.8244
p.R589H	ACH-001517	Endometrial/Uterine Cancer	CCLE	PAVTPVDE	DEG_SCF_FBW7_2	0.8244
p.R589H	HEC-1	endometrium	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	0.8244
p.V598A	SIDM00498	Colorectal Carcinoma	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	0.0833
p.V598A	SNU-C5	large_intestine	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	0.0833
p.V575F	SIDM01009	Neuroblastoma	GDSC	PAVTPVDE	DEG_SCF_FBW7_2	0.1389
p.V575F	KELLY	autonomic_ganglia	COSMIC	PAVTPVDE	DEG_SCF_FBW7_2	0.1389
p.N587S	ACH-000992	Head and Neck Cancer	CCLE	PAVTPVDE	DEG_SCF_FBW7_2	0.7069

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PAVTPVDE

Degron related mutations and impact score

Drug responses associated with SIK3 mutations

All proteins holding degron of PAVTPVDE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2K2	Serine/threonine-protein kinase SIK3	DEG_SCF_FBW7_2	582:589	PAVTPVDE	FBXW7	0.9804	More...