DegronMD - Q8TF68(ZNF384)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G64V	TCGA-13-0910	OV	TCGA	LAPPHYPTLLTV	DEG_ODPH_VHL_1	44:55	Mutation rewiring degron network	0.0833
p.G64V	TCGA-17-Z042	LUAD	TCGA	LAPPHYPTLLTV	DEG_ODPH_VHL_1	44:55	Mutation rewiring degron network	0.0833
p.G64V	DO29186	OV	ICGC	LAPPHYPTLLTV	DEG_ODPH_VHL_1	44:55	Mutation rewiring degron network	0.0833
p.A554V	TCGA-AX-A2HD	UCEC	TCGA	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation rewiring degron network	0.3056
p.A554V	TCGA-AX-A2HD	UCEC	TCGA	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation rewiring degron network	0.2778
p.A554V	SIDM00572	Gastric Carcinoma	GDSC	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation rewiring degron network	0.3056
p.A554V	SIDM00572	Gastric Carcinoma	GDSC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation rewiring degron network	0.2778
p.A554V	SIDM00607	Glioblastoma	GDSC	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation rewiring degron network	0.3056
p.A554V	SIDM00607	Glioblastoma	GDSC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation rewiring degron network	0.2778
p.A554V	NUGC-3	stomach	COSMIC	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation rewiring degron network	0.3056
p.A554V	NUGC-3	stomach	COSMIC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation rewiring degron network	0.2778
p.A554V	KNS-42	central nervous system	COSMIC	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation rewiring degron network	0.3056
p.A554V	KNS-42	central nervous system	COSMIC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation rewiring degron network	0.2778
p.T553M	TCGA-BR-4370	STAD	TCGA	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation altering degron motif	0.7423
p.P550S	TCGA-CV-7568	HNSC	TCGA	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation altering degron motif	0.6752
p.P550S	TCGA-CV-7568	HNSC	TCGA	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation altering degron motif	0.6752
p.P550S	TCGA-D9-A4Z3	SKCM	TCGA	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation altering degron motif	0.6752
p.P550S	TCGA-D9-A4Z3	SKCM	TCGA	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation altering degron motif	0.6752
p.P538L	TCGA-CV-A468	HNSC	TCGA	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation rewiring degron network	0.0556
p.P538L	TCGA-CV-A468	HNSC	TCGA	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation rewiring degron network	0.1389
p.P538S	TCGA-CV-A468	HNSC	TCGA	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation rewiring degron network	0.0556
p.P538S	TCGA-CV-A468	HNSC	TCGA	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation rewiring degron network	0.1389
p.P538S	DO52070	HNSC	ICGC	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation rewiring degron network	0.0556
p.P538S	DO52070	HNSC	ICGC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation rewiring degron network	0.1389
p.P550L	TCGA-D9-A4Z3	SKCM	TCGA	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation altering degron motif	0.7582
p.P550L	TCGA-D9-A4Z3	SKCM	TCGA	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation altering degron motif	0.7582
p.P550L	DO229453	SKCA	ICGC	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation altering degron motif	0.7582
p.P550L	DO229453	SKCA	ICGC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation altering degron motif	0.7582
p.P550L	DO47555	SKCM	ICGC	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation altering degron motif	0.7582
p.P550L	DO47555	SKCM	ICGC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation altering degron motif	0.7582
p.A554E	TCGA-EO-A22U	UCEC	TCGA	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation rewiring degron network	0.3056
p.A554E	TCGA-EO-A22U	UCEC	TCGA	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation rewiring degron network	0.2778
p.C561G	TCGA-FI-A2D5	UCEC	TCGA	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation rewiring degron network	0.1111
p.C561G	TCGA-FI-A2D5	UCEC	TCGA	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation rewiring degron network	0.0833
p.I560M	DO223037	ESCA	ICGC	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation rewiring degron network	0.1389
p.I560M	DO223037	ESCA	ICGC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation rewiring degron network	0.1111
p.H557R	DO231745	LINC	ICGC	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation rewiring degron network	0.2222
p.H557R	DO231745	LINC	ICGC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation rewiring degron network	0.1944
p.P542L	SIDM00545	Melanoma	GDSC	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation rewiring degron network	0.1667
p.P542L	SIDM00545	Melanoma	GDSC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation rewiring degron network	0.25
p.P542L	Mewo	skin	COSMIC	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation rewiring degron network	0.1667
p.P542L	Mewo	skin	COSMIC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation rewiring degron network	0.25
p.T553P	SIDM00845	Burkitt's Lymphoma	GDSC	LTPYKT	DEG_SCF_FBW7_1	548:553	Mutation altering degron motif	0.7031
p.D535E	SIDM01102	Non-Cancerous	GDSC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation rewiring degron network	0.0556
p.D535E	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation rewiring degron network	0.0556
p.P47L	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	LAPPHYPTLLTV	DEG_ODPH_VHL_1	44:55	Mutation altering degron motif	0.6471
p.P47L	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	PPHY	ITCH	46:49	Mutation altering degron motif	0.7582
p.P47L	ACH-000852	Lung Cancer	CCLE	LAPPHYPTLLTV	DEG_ODPH_VHL_1	44:55	Mutation altering degron motif	0.6471
p.P47L	ACH-000852	Lung Cancer	CCLE	PPHY	ITCH	46:49	Mutation altering degron motif	0.7582
p.P47L	NCI-H1435	lung	COSMIC	LAPPHYPTLLTV	DEG_ODPH_VHL_1	44:55	Mutation altering degron motif	0.6471
p.P47L	NCI-H1435	lung	COSMIC	PPHY	ITCH	46:49	Mutation altering degron motif	0.7582
p.S536C	SIDM00497	Colorectal Carcinoma	GDSC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	545:552	Mutation rewiring degron network	0.0833
p.S58P	ACH-000903	Thyroid Cancer	CCLE	LAPPHYPTLLTV	DEG_ODPH_VHL_1	44:55	Mutation rewiring degron network	0.25
p.S58P	ACH-000903	Thyroid Cancer	CCLE	PPHY	ITCH	46:49	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF384

UniProt ID: Q8TF68

Entrez ID: 171017

Protein name: Zinc finger protein 384 (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (Trinucleotide repeat-containing gene 1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF384 in