DegronMD

Uniprot ID: Q8TF68

Source protein: Zinc finger protein 384

Source gene: ZNF384

Class: DEG_SCF_SKP2-CKS1_1

Location: 545:552

E3 ligase: SKP2,CSK1

DEGRON score: 0.965

ASA_SCORE: 81.6125

COIL: 0.8044

CONS_SCORE: 0.5019

DSS_SCORE: 0.5447

HELIX: 0.051

FCONS_SCORE: 1.0693

RIG_SCORE: 0.7284

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A554V	TCGA-AX-A2HD	UCEC	TCGA	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.2778
p.A554V	SIDM00572	Gastric Carcinoma	GDSC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.2778
p.A554V	SIDM00607	Glioblastoma	GDSC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.2778
p.A554V	NUGC-3	stomach	COSMIC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.2778
p.A554V	KNS-42	central_nervous_system	COSMIC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.2778
p.P550S	TCGA-CV-7568	HNSC	TCGA	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.6752
p.P550S	TCGA-D9-A4Z3	SKCM	TCGA	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.6752
p.P538L	TCGA-CV-A468	HNSC	TCGA	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.1389
p.P538S	TCGA-CV-A468	HNSC	TCGA	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.1389
p.P538S	DO52070	HNSC	ICGC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.1389
p.P550L	TCGA-D9-A4Z3	SKCM	TCGA	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P550L	DO229453	SKCA	ICGC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P550L	DO47555	SKCM	ICGC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.7582
p.A554E	TCGA-EO-A22U	UCEC	TCGA	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.2778
p.C561G	TCGA-FI-A2D5	UCEC	TCGA	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.0833
p.I560M	DO223037	ESCA	ICGC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.1111
p.H557R	DO231745	LINC	ICGC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P542L	SIDM00545	Melanoma	GDSC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.25
p.P542L	Mewo	skin	COSMIC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.25
p.D535E	SIDM01102	Non-Cancerous	GDSC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.0556
p.D535E	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.0556
p.S536C	SIDM00497	Colorectal Carcinoma	GDSC	SFDLTPYK	DEG_SCF_SKP2-CKS1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF68	Zinc finger protein 384	DEG_SCF_SKP2-CKS1_1	545:552	SFDLTPYK	SKP2,CSK1	0.965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons