DegronMD

Uniprot ID: Q8TF68

Source protein: Zinc finger protein 384

Source gene: ZNF384

Class: DEG_SCF_FBW7_1

Location: 548:553

E3 ligase: FBXW7

DEGRON score: 0.8883

ASA_SCORE: 75.8667

COIL: 0.7115

CONS_SCORE: 0.4837

DSS_SCORE: 0.4594

HELIX: 0.1

FCONS_SCORE: 0.9756

RIG_SCORE: 0.7278

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A554V	TCGA-AX-A2HD	UCEC	TCGA	LTPYKT	DEG_SCF_FBW7_1	0.3056
p.A554V	SIDM00572	Gastric Carcinoma	GDSC	LTPYKT	DEG_SCF_FBW7_1	0.3056
p.A554V	SIDM00607	Glioblastoma	GDSC	LTPYKT	DEG_SCF_FBW7_1	0.3056
p.A554V	NUGC-3	stomach	COSMIC	LTPYKT	DEG_SCF_FBW7_1	0.3056
p.A554V	KNS-42	central_nervous_system	COSMIC	LTPYKT	DEG_SCF_FBW7_1	0.3056
p.T553M	TCGA-BR-4370	STAD	TCGA	LTPYKT	DEG_SCF_FBW7_1	0.7423
p.P550S	TCGA-CV-7568	HNSC	TCGA	LTPYKT	DEG_SCF_FBW7_1	0.6752
p.P550S	TCGA-D9-A4Z3	SKCM	TCGA	LTPYKT	DEG_SCF_FBW7_1	0.6752
p.P538L	TCGA-CV-A468	HNSC	TCGA	LTPYKT	DEG_SCF_FBW7_1	0.0556
p.P538S	TCGA-CV-A468	HNSC	TCGA	LTPYKT	DEG_SCF_FBW7_1	0.0556
p.P538S	DO52070	HNSC	ICGC	LTPYKT	DEG_SCF_FBW7_1	0.0556
p.P550L	TCGA-D9-A4Z3	SKCM	TCGA	LTPYKT	DEG_SCF_FBW7_1	0.7582
p.P550L	DO229453	SKCA	ICGC	LTPYKT	DEG_SCF_FBW7_1	0.7582
p.P550L	DO47555	SKCM	ICGC	LTPYKT	DEG_SCF_FBW7_1	0.7582
p.A554E	TCGA-EO-A22U	UCEC	TCGA	LTPYKT	DEG_SCF_FBW7_1	0.3056
p.C561G	TCGA-FI-A2D5	UCEC	TCGA	LTPYKT	DEG_SCF_FBW7_1	0.1111
p.I560M	DO223037	ESCA	ICGC	LTPYKT	DEG_SCF_FBW7_1	0.1389
p.H557R	DO231745	LINC	ICGC	LTPYKT	DEG_SCF_FBW7_1	0.2222
p.P542L	SIDM00545	Melanoma	GDSC	LTPYKT	DEG_SCF_FBW7_1	0.1667
p.P542L	Mewo	skin	COSMIC	LTPYKT	DEG_SCF_FBW7_1	0.1667
p.T553P	SIDM00845	Burkitt's Lymphoma	GDSC	LTPYKT	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF68	Zinc finger protein 384	DEG_SCF_FBW7_1	548:553	LTPYKT	FBXW7	0.8883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons