DegronMD - Q6ZRV2(FAM83H)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P674A	TCGA-21-1083	LUSC	TCGA	FRSRLNPLV	DEG_APCC_DBOX_1	668:676	Mutation altering degron motif	0.6392
p.P674A	DO26769	LUSC	ICGC	FRSRLNPLV	DEG_APCC_DBOX_1	668:676	Mutation altering degron motif	0.6392
p.R671L	TCGA-39-5016	LUSC	TCGA	FRSRLNPLV	DEG_APCC_DBOX_1	668:676	Mutation altering degron motif	0.7316
p.R671L	DO26701	LUSC	ICGC	FRSRLNPLV	DEG_APCC_DBOX_1	668:676	Mutation altering degron motif	0.7316
p.A874S	TCGA-43-5668	LUSC	TCGA	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation rewiring degron network	0.1111
p.A874S	DO26608	LUSC	ICGC	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation rewiring degron network	0.1111
p.G18E	TCGA-56-7221	LUSC	TCGA	PPHY	ITCH	21:24	Mutation rewiring degron network	0.25
p.G18E	DO26689	LUSC	ICGC	PPHY	ITCH	21:24	Mutation rewiring degron network	0.25
p.V104L	TCGA-85-A50Z	LUSC	TCGA	SDQAVPEL	DEG_COP1_1	100:107	Mutation altering degron motif	0.6765
p.V104L	DO45462	LUSC	ICGC	SDQAVPEL	DEG_COP1_1	100:107	Mutation altering degron motif	0.6765
p.R889Q	TCGA-A5-A2K5	UCEC	TCGA	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation rewiring degron network	0.2778
p.R889Q	TCGA-AA-A010	COAD	TCGA	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation rewiring degron network	0.2778
p.R889Q	DO41379	UCEC	ICGC	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation rewiring degron network	0.2778
p.D12G	TCGA-AA-3947	COAD	TCGA	PPHY	ITCH	21:24	Mutation rewiring degron network	0.0833
p.D12G	DO8192	COAD	ICGC	PPHY	ITCH	21:24	Mutation rewiring degron network	0.0833
p.T883M	TCGA-AZ-6601	COAD	TCGA	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation altering degron motif	0.8534
p.T883M	DO8119	COAD	ICGC	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation altering degron motif	0.8534
p.E877G	TCGA-B5-A1MX	UCEC	TCGA	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation rewiring degron network	0.1944
p.E877G	DO41999	UCEC	ICGC	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation rewiring degron network	0.1944
p.V104M	TCGA-B5-A3FC	UCEC	TCGA	SDQAVPEL	DEG_COP1_1	100:107	Mutation altering degron motif	0.7208
p.V104M	DO41871	UCEC	ICGC	SDQAVPEL	DEG_COP1_1	100:107	Mutation altering degron motif	0.7208
p.R29C	TCGA-CC-5262	LIHC	TCGA	PPHY	ITCH	21:24	Mutation rewiring degron network	0.1944
p.R29C	DO50973	LICA	ICGC	PPHY	ITCH	21:24	Mutation rewiring degron network	0.1944
p.R29C	DO22953	LIHC	ICGC	PPHY	ITCH	21:24	Mutation rewiring degron network	0.1944
p.T894S	TCGA-CQ-6225	HNSC	TCGA	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation blocking phosphorylation signal	0.5833
p.T894S	DO14260	HNSC	ICGC	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation blocking phosphorylation signal	0.5833
p.A34E	TCGA-DM-A1D8	COAD	TCGA	PPHY	ITCH	21:24	Mutation rewiring degron network	0.0556
p.A34E	DO8914	COAD	ICGC	PPHY	ITCH	21:24	Mutation rewiring degron network	0.0556
p.P21A	TCGA-EE-A20B	SKCM	TCGA	PPHY	ITCH	21:24	Mutation altering degron motif	0.7503
p.P21A	DO37547	SKCM	ICGC	PPHY	ITCH	21:24	Mutation altering degron motif	0.7503
p.Q102K	TCGA-GN-A26A	SKCM	TCGA	SDQAVPEL	DEG_COP1_1	100:107	Mutation altering degron motif	0.5833
p.Q102K	DO37861	SKCM	ICGC	SDQAVPEL	DEG_COP1_1	100:107	Mutation altering degron motif	0.5833
p.A103V	TCGA-IB-7651	PAAD	TCGA	SDQAVPEL	DEG_COP1_1	100:107	Mutation altering degron motif	0.5825
p.A103V	DO46657	PAAD	ICGC	SDQAVPEL	DEG_COP1_1	100:107	Mutation altering degron motif	0.5825
p.R669S	DO9708	COAD	ICGC	FRSRLNPLV	DEG_APCC_DBOX_1	668:676	Mutation altering degron motif	0.7427
p.A31V	DO222874	COCA	ICGC	PPHY	ITCH	21:24	Mutation rewiring degron network	0.1389
p.R878Q	DO52450	COCA	ICGC	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation rewiring degron network	0.2222
p.G116R	SIDM00928	Breast Carcinoma	GDSC	SDQAVPEL	DEG_COP1_1	100:107	Mutation rewiring degron network	0.0833
p.G116R	CAL-85-1	breast	COSMIC	SDQAVPEL	DEG_COP1_1	100:107	Mutation rewiring degron network	0.0833
p.P14L	SIDM00821	Kidney Carcinoma	GDSC	PPHY	ITCH	21:24	Mutation rewiring degron network	0.1389
p.P14L	ACH-002187	Kidney Cancer	CCLE	PPHY	ITCH	21:24	Mutation rewiring degron network	0.1389
p.P14L	RCC-AB	kidney	COSMIC	PPHY	ITCH	21:24	Mutation rewiring degron network	0.1389
p.R890T	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation rewiring degron network	0.25
p.R890T	ACH-000945	Lung Cancer	CCLE	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation rewiring degron network	0.25
p.R890T	NCI-H650	lung	COSMIC	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation rewiring degron network	0.25
p.P893Q	SIDM00875	Breast Carcinoma	GDSC	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation rewiring degron network	0.1667
p.P893Q	SIDM01664	Prostate Carcinoma	GDSC	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation rewiring degron network	0.1667
p.D666H	SIDM00887	Other Solid Cancers	GDSC	FRSRLNPLV	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.2778
p.D666H	ACH-000211	Brain Cancer	CCLE	FRSRLNPLV	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.2778
p.F115L	SIDM00451	T-Lymphoblastic Leukemia	GDSC	SDQAVPEL	DEG_COP1_1	100:107	Mutation rewiring degron network	0.1111
p.F115L	ACH-000937	Leukemia	CCLE	SDQAVPEL	DEG_COP1_1	100:107	Mutation rewiring degron network	0.1111
p.F115L	PF-382	haematopoietic and lymphoid tissue	COSMIC	SDQAVPEL	DEG_COP1_1	100:107	Mutation rewiring degron network	0.1111
p.R669C	ACH-000591	Brain Cancer	CCLE	FRSRLNPLV	DEG_APCC_DBOX_1	668:676	Mutation altering degron motif	0.8301
p.A34T	ACH-000836	Head and Neck Cancer	CCLE	PPHY	ITCH	21:24	Mutation rewiring degron network	0.0556
p.Y875C	ACH-000919	Gastric Cancer	CCLE	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation blocking phosphorylation signal	0.5833
p.Y875C	IM-95	stomach	COSMIC	PTPGFS	DEG_SCF_FBW7_1	882:887	Mutation blocking phosphorylation signal	0.5833
p.K25E	ACH-001061	Colon/Colorectal Cancer	CCLE	PPHY	ITCH	21:24	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM83H

UniProt ID: Q6ZRV2

Entrez ID: 286077

Protein name: Protein FAM83H

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM83H in