DegronMD

Uniprot ID: Q6ZRV2

Source protein: Protein FAM83H

Source gene: FAM83H

Class: DEG_APCC_DBOX_1

Location: 668:676

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9975

ASA_SCORE: 89.5778

COIL: 0.79

CONS_SCORE: 0.8518

DSS_SCORE: 0.5699

HELIX: 0.1653

FCONS_SCORE: 1.0655

RIG_SCORE: 0.7416

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P674A	TCGA-21-1083	LUSC	TCGA	FRSRLNPLV	DEG_APCC_DBOX_1	0.6392
p.P674A	DO26769	LUSC	ICGC	FRSRLNPLV	DEG_APCC_DBOX_1	0.6392
p.R671L	TCGA-39-5016	LUSC	TCGA	FRSRLNPLV	DEG_APCC_DBOX_1	0.7316
p.R671L	DO26701	LUSC	ICGC	FRSRLNPLV	DEG_APCC_DBOX_1	0.7316
p.R669S	DO9708	COAD	ICGC	FRSRLNPLV	DEG_APCC_DBOX_1	0.7427
p.D666H	SIDM00887	Other Solid Cancers	GDSC	FRSRLNPLV	DEG_APCC_DBOX_1	0.2778
p.D666H	ACH-000211	Brain Cancer	CCLE	FRSRLNPLV	DEG_APCC_DBOX_1	0.2778
p.R669C	ACH-000591	Brain Cancer	CCLE	FRSRLNPLV	DEG_APCC_DBOX_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRV2	Protein FAM83H	DEG_APCC_DBOX_1	668:676	FRSRLNPLV	APC,CDC20,FZR1	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons