DegronMD

Uniprot ID: Q6ZRV2

Source protein: Protein FAM83H

Source gene: FAM83H

Class: DEG_COP1_1

Location: 100:107

E3 ligase: COP1

DEGRON score: 0.9936

ASA_SCORE: 77.5375

COIL: 0.8324

CONS_SCORE: 0.8251

DSS_SCORE: 0.3899

HELIX: 0.1175

FCONS_SCORE: 1.0143

RIG_SCORE: 0.7958

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V104L	TCGA-85-A50Z	LUSC	TCGA	SDQAVPEL	DEG_COP1_1	0.6765
p.V104L	DO45462	LUSC	ICGC	SDQAVPEL	DEG_COP1_1	0.6765
p.V104M	TCGA-B5-A3FC	UCEC	TCGA	SDQAVPEL	DEG_COP1_1	0.7208
p.V104M	DO41871	UCEC	ICGC	SDQAVPEL	DEG_COP1_1	0.7208
p.Q102K	TCGA-GN-A26A	SKCM	TCGA	SDQAVPEL	DEG_COP1_1	0.5833
p.Q102K	DO37861	SKCM	ICGC	SDQAVPEL	DEG_COP1_1	0.5833
p.A103V	TCGA-IB-7651	PAAD	TCGA	SDQAVPEL	DEG_COP1_1	0.5825
p.A103V	DO46657	PAAD	ICGC	SDQAVPEL	DEG_COP1_1	0.5825
p.G116R	SIDM00928	Breast Carcinoma	GDSC	SDQAVPEL	DEG_COP1_1	0.0833
p.G116R	CAL-85-1	breast	COSMIC	SDQAVPEL	DEG_COP1_1	0.0833
p.F115L	SIDM00451	T-Lymphoblastic Leukemia	GDSC	SDQAVPEL	DEG_COP1_1	0.1111
p.F115L	ACH-000937	Leukemia	CCLE	SDQAVPEL	DEG_COP1_1	0.1111
p.F115L	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	SDQAVPEL	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRV2	Protein FAM83H	DEG_COP1_1	100:107	SDQAVPEL	COP1	0.9936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons