DegronMD

Uniprot ID: Q6ZRV2

Source protein: Protein FAM83H

Source gene: FAM83H

Class: DEG_SCF_FBW7_1

Location: 882:887

E3 ligase: FBXW7

DEGRON score: 0.9599

ASA_SCORE: 91.4333

COIL: 0.9673

CONS_SCORE: 0.3144

DSS_SCORE: 0.7659

HELIX: 0.0137

FCONS_SCORE: 0.8742

RIG_SCORE: 0.5694

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A874S	TCGA-43-5668	LUSC	TCGA	PTPGFS	DEG_SCF_FBW7_1	0.1111
p.A874S	DO26608	LUSC	ICGC	PTPGFS	DEG_SCF_FBW7_1	0.1111
p.R889Q	TCGA-A5-A2K5	UCEC	TCGA	PTPGFS	DEG_SCF_FBW7_1	0.2778
p.R889Q	TCGA-AA-A010	COAD	TCGA	PTPGFS	DEG_SCF_FBW7_1	0.2778
p.R889Q	DO41379	UCEC	ICGC	PTPGFS	DEG_SCF_FBW7_1	0.2778
p.T883M	TCGA-AZ-6601	COAD	TCGA	PTPGFS	DEG_SCF_FBW7_1	0.8534
p.T883M	DO8119	COAD	ICGC	PTPGFS	DEG_SCF_FBW7_1	0.8534
p.E877G	TCGA-B5-A1MX	UCEC	TCGA	PTPGFS	DEG_SCF_FBW7_1	0.1944
p.E877G	DO41999	UCEC	ICGC	PTPGFS	DEG_SCF_FBW7_1	0.1944
p.T894S	TCGA-CQ-6225	HNSC	TCGA	PTPGFS	DEG_SCF_FBW7_1	0.5833
p.T894S	DO14260	HNSC	ICGC	PTPGFS	DEG_SCF_FBW7_1	0.5833
p.R878Q	DO52450	COCA	ICGC	PTPGFS	DEG_SCF_FBW7_1	0.2222
p.R890T	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PTPGFS	DEG_SCF_FBW7_1	0.25
p.R890T	ACH-000945	Lung Cancer	CCLE	PTPGFS	DEG_SCF_FBW7_1	0.25
p.R890T	NCI-H650	lung	COSMIC	PTPGFS	DEG_SCF_FBW7_1	0.25
p.P893Q	SIDM00875	Breast Carcinoma	GDSC	PTPGFS	DEG_SCF_FBW7_1	0.1667
p.P893Q	SIDM01664	Prostate Carcinoma	GDSC	PTPGFS	DEG_SCF_FBW7_1	0.1667
p.Y875C	ACH-000919	Gastric Cancer	CCLE	PTPGFS	DEG_SCF_FBW7_1	0.5833
p.Y875C	IM-95	stomach	COSMIC	PTPGFS	DEG_SCF_FBW7_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRV2	Protein FAM83H	DEG_SCF_FBW7_1	882:887	PTPGFS	FBXW7	0.9599	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons