DegronMD

Uniprot ID: P14866

Source protein: Heterogeneous nuclear ribonucleoprotein L

Source gene: HNRNPL

Class: ITCH

Location: 337:340

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9935

ASA_SCORE: 52.9

COIL: 0.8748

CONS_SCORE: 0.3464

DSS_SCORE: 0.6803

HELIX: 0.0478

FCONS_SCORE: 1.0195

RIG_SCORE: 0.5873

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E341K	TCGA-C5-A1MI	CESC	TCGA	PPHY	ITCH	0.3056
p.M345I	TCGA-FS-A1ZQ	SKCM	TCGA	PPHY	ITCH	0.1944
p.M345I	ACH-000717	Esophageal Cancer	CCLE	PPHY	ITCH	0.1944
p.S331L	DO2401	BRCA	ICGC	PPHY	ITCH	0.1667
p.R348Q	DO22920	LIHC	ICGC	PPHY	ITCH	0.1111
p.R348W	DO38607	STAD	ICGC	PPHY	ITCH	0.1111
p.S345G	DO40804	UCEC	ICGC	PPHY	ITCH	0.1944
p.P335A	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPHY	ITCH	0.2778
p.P335A	ACH-000995	Leukemia	CCLE	PPHY	ITCH	0.2778
p.P338A	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	PPHY	ITCH	0.7503
p.H339Y	SIDM01624	Bladder Carcinoma	GDSC	PPHY	ITCH	0.6118
p.H339Y	ACH-000026	Bladder Cancer	CCLE	PPHY	ITCH	0.6118

Drug responses associated with HNRNPL mutations

All proteins holding degron of PPHY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15156	Zinc finger and BTB domain-containing protein 7B	ITCH	468:471	PPHY	ITCH,NEDD4	0.632	More...
O75081	Protein CBFA2T3	ITCH	339:342	PPHY	ITCH,NEDD4	0.9949	More...
O75618	Death effector domain-containing protein	ITCH	146:149	PPHY	ITCH,NEDD4	0.9035	More...
O75923	Dysferlin	ITCH	194:197	PPHY	ITCH,NEDD4	0.877	More...
O94855	Protein transport protein Sec24D	ITCH	23:26	PPHY	ITCH,NEDD4	0.9579	More...
P14866	Heterogeneous nuclear ribonucleoprotein L	ITCH	337:340	PPHY	ITCH,NEDD4	0.9935	More...
P56693	Transcription factor SOX-10	ITCH	366:369	PPHY	ITCH,NEDD4	0.9951	More...
P62072	Mitochondrial import inner membrane translocase subunit Tim10	ITCH	35:38	PPHY	ITCH,NEDD4	0.6439	More...
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	ITCH	1704:1707	PPHY	ITCH,NEDD4	0.6355	More...
Q13227	G protein pathway suppressor 2	ITCH	194:197	PPHY	ITCH,NEDD4	0.9693	More...
Q13621	Solute carrier family 12 member 1	ITCH	42:45	PPHY	ITCH,NEDD4	0.9792	More...
Q6W2J9	BCL-6 corepressor	ITCH	249:252	PPHY	ITCH,NEDD4	0.7281	More...
Q6ZRV2	Protein FAM83H	ITCH	21:24	PPHY	ITCH,NEDD4	0.9628	More...
Q7Z4S6	Kinesin-like protein KIF21A	ITCH	1540:1543	PPHY	ITCH,NEDD4	0.7904	More...
Q86Y56	Dynein axonemal assembly factor 5	ITCH	335:338	PPHY	ITCH,NEDD4	0.6455	More...
Q8NC67	Neuropilin and tolloid-like protein 2	ITCH	395:398	PPHY	ITCH,NEDD4	0.9529	More...
Q8NEA6	Zinc finger protein GLIS3	ITCH	680:683	PPHY	ITCH,NEDD4	0.969	More...
Q8NFH8	RalBP1-associated Eps domain-containing protein 2	ITCH	200:203	PPHY	ITCH,NEDD4	0.9985	More...
Q9NZB2	Constitutive coactivator of PPAR-gamma-like protein 1	ITCH	339:342	PPHY	ITCH,NEDD4	0.7758	More...
Q9Y2G1	Myelin regulatory factor	ITCH	195:198	PPHY	ITCH,NEDD4	0.9944	More...
Q9Y2K2	Serine/threonine-protein kinase SIK3	ITCH	939:942	PPHY	ITCH,NEDD4	0.9973	More...
Q8TF68	Zinc finger protein 384	ITCH	46:49	PPHY	ITCH,NEDD4	0.9991	More...
Q96A35	39S ribosomal protein L24, mitochondrial	ITCH	16:19	PPHY	ITCH,NEDD4	0.837	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPHY

Degron related mutations and impact score

Drug responses associated with HNRNPL mutations

All proteins holding degron of PPHY