DegronMD - Q8NEA6(GLIS3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P688T	TCGA-05-4396	LUAD	TCGA	PPHY	ITCH	680:683	Mutation rewiring degron network	0.1944
p.P688T	DO23838	LUAD	ICGC	PPHY	ITCH	680:683	Mutation rewiring degron network	0.1944
p.T674K	TCGA-66-2787	LUSC	TCGA	PPHY	ITCH	680:683	Mutation rewiring degron network	0.1667
p.T674K	DO229006	LICA	ICGC	PPHY	ITCH	680:683	Mutation rewiring degron network	0.1667
p.T674K	DO26647	LUSC	ICGC	PPHY	ITCH	680:683	Mutation rewiring degron network	0.1667
p.R297C	TCGA-A6-6653	COAD	TCGA	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1389
p.R297C	DO10373	COAD	ICGC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1389
p.R297H	TCGA-AP-A1DK	UCEC	TCGA	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1389
p.R297H	DO42033	UCEC	ICGC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1389
p.L303M	TCGA-AX-A06F	UCEC	TCGA	PPPY	ITCH	304:307	Mutation rewiring degron network	0.3056
p.L303M	DO41752	UCEC	ICGC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.3056
p.G313R	TCGA-CG-5728	STAD	TCGA	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1667
p.G313R	DO38619	STAD	ICGC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1667
p.G313R	SIDM01086	B-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1667
p.G313R	ACH-000874	Leukemia	CCLE	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1667
p.G313R	RS4-11	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1667
p.V679M	TCGA-DB-A64L	LGG	TCGA	PPHY	ITCH	680:683	Mutation rewiring degron network	0.3056
p.V679M	DO44615	LGG	ICGC	PPHY	ITCH	680:683	Mutation rewiring degron network	0.3056
p.D675N	TCGA-EE-A20C	SKCM	TCGA	PPHY	ITCH	680:683	Mutation rewiring degron network	0.1944
p.D675N	DO222775	MELA	ICGC	PPHY	ITCH	680:683	Mutation rewiring degron network	0.1944
p.D675N	DO47665	SKCM	ICGC	PPHY	ITCH	680:683	Mutation rewiring degron network	0.1944
p.A302V	TCGA-EO-A22U	UCEC	TCGA	PPPY	ITCH	304:307	Mutation rewiring degron network	0.2778
p.A302V	DO43755	UCEC	ICGC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.2778
p.D675H	TCGA-FD-A3B6	BLCA	TCGA	PPHY	ITCH	680:683	Mutation rewiring degron network	0.1944
p.D675H	DO458	BLCA	ICGC	PPHY	ITCH	680:683	Mutation rewiring degron network	0.1944
p.A296T	TCGA-FR-A726	SKCM	TCGA	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1111
p.A296T	DO48665	SKCM	ICGC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1111
p.K299N	TCGA-ND-A4WC	UCS	TCGA	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1944
p.K299N	TCGA-ZF-AA5P	BLCA	TCGA	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1944
p.K299N	DO219103	BLCA	ICGC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1944
p.S309C	TCGA-QQ-A5VD	SARC	TCGA	PPPY	ITCH	304:307	Mutation rewiring degron network	0.2778
p.S309C	DO220252	SARC	ICGC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.2778
p.L305F	TCGA-VR-A8EX	ESCA	TCGA	PPPY	ITCH	304:307	Mutation altering degron motif	0.6981
p.A302G	DO224563	LUSC	ICGC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.2778
p.P688H	DO228253	MALY	ICGC	PPHY	ITCH	680:683	Mutation rewiring degron network	0.1944
p.A693D	DO46779	PAEN	ICGC	PPHY	ITCH	680:683	Mutation rewiring degron network	0.0556
p.S298Y	SIDM00541	Colorectal Carcinoma	GDSC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1667
p.S298Y	SIDM00212	Glioblastoma	GDSC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1667
p.S298Y	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1667
p.S298Y	SIDM01161	Other Sarcomas	GDSC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1667
p.S298Y	SIDM00311	Mesothelioma	GDSC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1667
p.S298Y	SIDM01567	Hodgkin's Lymphoma	GDSC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1667
p.G313E	SIDM00082	Melanoma	GDSC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1667
p.G313E	SK-MEL-2	skin	COSMIC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1667
p.E317D	TGBC11TKB	stomach	COSMIC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.0556
p.P299S	MZ7-mel	skin	COSMIC	PPPY	ITCH	304:307	Mutation rewiring degron network	0.1944
p.P692L	SNU-C5	large intestine	COSMIC	PPHY	ITCH	680:683	Mutation rewiring degron network	0.0833

Kaplan plot for GLIS3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GLIS3

UniProt ID: Q8NEA6

Entrez ID: 169792

Protein name: Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GLIS3 in