DegronMD

Uniprot ID: Q8NEA6

Source protein: Zinc finger protein GLIS3

Source gene: GLIS3

Class: ITCH

Location: 304:307

E3 ligase: ITCH,NEDD4

DEGRON score: 0.5841

ASA_SCORE: 97.65

COIL: 0.9043

CONS_SCORE: 0.5786

DSS_SCORE: 0.7191

HELIX: 0.0733

FCONS_SCORE: 1.0611

RIG_SCORE: 0.4279

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L305F	TCGA-VR-A8EX	ESCA	TCGA	PPPY	ITCH	0.6981
p.L303M	TCGA-AX-A06F	UCEC	TCGA	PPPY	ITCH	0.3056
p.L303M	DO41752	UCEC	ICGC	PPPY	ITCH	0.3056
p.A302V	TCGA-EO-A22U	UCEC	TCGA	PPPY	ITCH	0.2778
p.A302V	DO43755	UCEC	ICGC	PPPY	ITCH	0.2778
p.S309C	TCGA-QQ-A5VD	SARC	TCGA	PPPY	ITCH	0.2778
p.S309C	DO220252	SARC	ICGC	PPPY	ITCH	0.2778
p.A302G	DO224563	LUSC	ICGC	PPPY	ITCH	0.2778
p.K299N	TCGA-ND-A4WC	UCS	TCGA	PPPY	ITCH	0.1944
p.K299N	TCGA-ZF-AA5P	BLCA	TCGA	PPPY	ITCH	0.1944
p.K299N	DO219103	BLCA	ICGC	PPPY	ITCH	0.1944
p.P299S	MZ7-mel	skin	COSMIC	PPPY	ITCH	0.1944
p.G313R	TCGA-CG-5728	STAD	TCGA	PPPY	ITCH	0.1667
p.G313R	DO38619	STAD	ICGC	PPPY	ITCH	0.1667
p.G313R	SIDM01086	B-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	0.1667
p.G313R	ACH-000874	Leukemia	CCLE	PPPY	ITCH	0.1667
p.G313R	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	PPPY	ITCH	0.1667
p.S298Y	SIDM00541	Colorectal Carcinoma	GDSC	PPPY	ITCH	0.1667
p.S298Y	SIDM00212	Glioblastoma	GDSC	PPPY	ITCH	0.1667
p.S298Y	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPPY	ITCH	0.1667
p.S298Y	SIDM01161	Other Sarcomas	GDSC	PPPY	ITCH	0.1667
p.S298Y	SIDM00311	Mesothelioma	GDSC	PPPY	ITCH	0.1667
p.S298Y	SIDM01567	Hodgkin's Lymphoma	GDSC	PPPY	ITCH	0.1667
p.G313E	SIDM00082	Melanoma	GDSC	PPPY	ITCH	0.1667
p.G313E	SK-MEL-2	skin	COSMIC	PPPY	ITCH	0.1667

Showing 1 to 25 of 32 entries

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Drug responses associated with GLIS3 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPPY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DV4	39S ribosomal protein L38, mitochondrial	ITCH	347:350	PPPY	ITCH,NEDD4	0.6466	More...
O15072	A disintegrin and metalloproteinase with thrombospondin motifs 3	ITCH	1058:1061	PPPY	ITCH,NEDD4	0.9797	More...
Q13625	Apoptosis-stimulating of p53 protein 2	ITCH	871:874	PPPY	ITCH,NEDD4	0.9885	More...
P54259	Atrophin-1	ITCH	445:448	PPPY	ITCH,NEDD4	0.973	More...
P54259	Atrophin-1	ITCH	636:639	PPPY	ITCH,NEDD4	0.9909	More...
Q8WXX7	Autism susceptibility gene 2 protein	ITCH	516:519	PPPY	ITCH,NEDD4	0.9979	More...
O00512	B-cell CLL/lymphoma 9 protein	ITCH	515:518	PPPY	ITCH,NEDD4	0.9973	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	ITCH	561:564	PPPY	ITCH,NEDD4	0.9923	More...
O95395	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3	ITCH	285:288	PPPY	ITCH,NEDD4	0.5532	More...
O95415	Brain protein I3	ITCH	39:42	PPPY	ITCH,NEDD4	0.9496	More...
Q15018	BRISC complex subunit Abraxas 2	ITCH	305:308	PPPY	ITCH,NEDD4	0.9939	More...
Q9P203	BTB/POZ domain-containing protein 7	ITCH	762:765	PPPY	ITCH,NEDD4	0.9575	More...
Q9Y6W3	Calpain-7	ITCH	624:627	PPPY	ITCH,NEDD4	0.5393	More...
Q8WXE0	Caskin-2	ITCH	751:754	PPPY	ITCH,NEDD4	0.6879	More...
Q9H305	Cell death-inducing p53-target protein 1	ITCH	6:9	PPPY	ITCH,NEDD4	0.9945	More...
Q9H305	Cell death-inducing p53-target protein 1	ITCH	51:54	PPPY	ITCH,NEDD4	0.9943	More...
Q16630	Cleavage and polyadenylation specificity factor subunit 6	ITCH	387:390	PPPY	ITCH,NEDD4	0.9919	More...
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	ITCH	704:707	PPPY	ITCH,NEDD4	0.9478	More...
Q86YQ8	Copine-8	ITCH	550:553	PPPY	ITCH,NEDD4	0.743	More...
Q6UUV7	CREB-regulated transcription coactivator 3	ITCH	445:448	PPPY	ITCH,NEDD4	0.998	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	113:116	PPPY	ITCH,NEDD4	0.9396	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	129:132	PPPY	ITCH,NEDD4	0.9428	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	145:148	PPPY	ITCH,NEDD4	0.9794	More...
Q9H1C7	Cysteine-rich and transmembrane domain-containing protein 1	ITCH	6:9	PPPY	ITCH,NEDD4	0.9391	More...
Q9BTC0	Death-inducer obliterator 1	ITCH	1817:1820	PPPY	ITCH,NEDD4	0.9967	More...

Showing 1 to 25 of 180 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPPY

Degron related mutations and impact score

Drug responses associated with GLIS3 mutations

All proteins holding degron of PPPY