DegronMD - O15049(N4BP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G220V	TCGA-25-1329	OV	TCGA	PFSSS	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.0833
p.G220V	DO31230	OV	ICGC	PFSSS	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.0833
p.S68I	TCGA-85-6561	LUSC	TCGA	QREFLSYLH	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.1111
p.S68I	DO26518	LUSC	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.1111
p.F250L	TCGA-AP-A0LM	UCEC	TCGA	PPPY	ITCH	245:248	Mutation rewiring degron network	0.2778
p.F250L	DO43306	UCEC	ICGC	PPPY	ITCH	245:248	Mutation rewiring degron network	0.2778
p.L46I	TCGA-AP-A1DK	UCEC	TCGA	QREFLSYLH	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.1667
p.L46I	DO42033	UCEC	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.1667
p.P246L	TCGA-AX-A0J1	UCEC	TCGA	PPPY	ITCH	245:248	Mutation altering degron motif	0.7582
p.P246L	DO41199	UCEC	ICGC	PPPY	ITCH	245:248	Mutation altering degron motif	0.7582
p.S200I	TCGA-AX-A2HD	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1389
p.S200I	DO42608	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1389
p.E54Q	TCGA-CQ-7071	HNSC	TCGA	QREFLSYLH	DEG_APCC_DBOX_1	52:60	Mutation altering degron motif	0.5633
p.E54Q	DO49069	HNSC	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	52:60	Mutation altering degron motif	0.5633
p.R53C	TCGA-HU-A4GN	STAD	TCGA	QREFLSYLH	DEG_APCC_DBOX_1	52:60	Mutation altering degron motif	0.8301
p.R53C	DO233941	GACA	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	52:60	Mutation altering degron motif	0.8301
p.R53C	DO47833	STAD	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	52:60	Mutation altering degron motif	0.8301
p.P201H	TCGA-IB-7651	PAAD	TCGA	PFSSS	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1667
p.P201H	DO46657	PAAD	ICGC	PFSSS	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1667
p.E249K	TCGA-MP-A4T4	LUAD	TCGA	PPPY	ITCH	245:248	Mutation rewiring degron network	0.3056
p.E249K	DO45357	LUAD	ICGC	PPPY	ITCH	245:248	Mutation rewiring degron network	0.3056
p.A255T	DO234230	ESAD	ICGC	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1389
p.A255T	SIDM00120	Prostate Carcinoma	GDSC	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1389
p.A255T	ACH-000979	Prostate Cancer	CCLE	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1389
p.A255T	DU-145	prostate	COSMIC	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1389
p.R47W	DO233882	GACA	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.1944
p.S206I	DO229031	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.3056
p.Q52R	DO50879	LICA	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	52:60	Mutation altering degron motif	0.6218
p.G44W	DO231641	LINC	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.1111
p.LL45LF	DO220903	MELA	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0
p.L46F	DO220903	MELA	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.1667
p.G219R	DO228142	PBCA	ICGC	PFSSS	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.1111
p.R53H	DO232761	PBCA	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	52:60	Mutation altering degron motif	0.8244
p.E256K	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1111
p.E256K	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1111
p.E256K	SIDM00383	Gastric Carcinoma	GDSC	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1111
p.E256K	SIDM00302	Other Solid Cancers	GDSC	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1111
p.E256K	SIDM01336	Glioblastoma	GDSC	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1111
p.E256K	SIDM01779	Gastric Carcinoma	GDSC	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1111
p.E256K	ACH-000368	Brain Cancer	CCLE	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1111
p.E256K	ACH-000561	Esophageal Cancer	CCLE	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1111
p.E256K	ACH-000761	Gastric Cancer	CCLE	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1111
p.E256K	ACH-000920	Leukemia	CCLE	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1111
p.E256K	ACH-002023	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1111
p.E256K	ACH-002149	Ovarian Cancer	CCLE	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1111
p.E256K	ACH-002198	Gastric Cancer	CCLE	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1111
p.E256K	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1111
p.E256K	T-T	oesophagus	COSMIC	PPPY	ITCH	245:248	Mutation rewiring degron network	0.1111
p.H214Q	SIDM01347	Ovarian Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.25
p.H214Q	ACH-000701	Ovarian Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.25
p.R47G	ACH-000367	Lung Cancer	CCLE	QREFLSYLH	DEG_APCC_DBOX_1	52:60	Mutation rewiring degron network	0.1944
p.S209R	ACH-000634	Brain Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	207:211	Mutation altering degron motif	0.7427
p.H214N	ACH-001378	Pancreatic Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

N4BP3

UniProt ID: O15049

Entrez ID: 23138

Protein name: NEDD4-binding protein 3 (N4BP3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for N4BP3 in