DegronMD

Uniprot ID: O15049

Source protein: NEDD4-binding protein 3

Source gene: N4BP3

Class: DEG_APCC_DBOX_1

Location: 52:60

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.506

ASA_SCORE: 85.7333

COIL: 0.6373

CONS_SCORE: 0.6782

DSS_SCORE: 0.4795

HELIX: 0.2922

FCONS_SCORE: 1.041

RIG_SCORE: 0.7582

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S68I	TCGA-85-6561	LUSC	TCGA	QREFLSYLH	DEG_APCC_DBOX_1	0.1111
p.S68I	DO26518	LUSC	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	0.1111
p.L46I	TCGA-AP-A1DK	UCEC	TCGA	QREFLSYLH	DEG_APCC_DBOX_1	0.1667
p.L46I	DO42033	UCEC	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	0.1667
p.E54Q	TCGA-CQ-7071	HNSC	TCGA	QREFLSYLH	DEG_APCC_DBOX_1	0.5633
p.E54Q	DO49069	HNSC	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	0.5633
p.R53C	TCGA-HU-A4GN	STAD	TCGA	QREFLSYLH	DEG_APCC_DBOX_1	0.8301
p.R53C	DO233941	GACA	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	0.8301
p.R53C	DO47833	STAD	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	0.8301
p.R47W	DO233882	GACA	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	0.1944
p.Q52R	DO50879	LICA	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	0.6218
p.G44W	DO231641	LINC	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	0.1111
p.LL45LF	DO220903	MELA	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	0
p.L46F	DO220903	MELA	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	0.1667
p.R53H	DO232761	PBCA	ICGC	QREFLSYLH	DEG_APCC_DBOX_1	0.8244
p.R47G	ACH-000367	Lung Cancer	CCLE	QREFLSYLH	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15049	NEDD4-binding protein 3	DEG_APCC_DBOX_1	52:60	QREFLSYLH	APC,CDC20,FZR1	0.506	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons