DegronMD - Q92481(TFAP2B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P130R	TCGA-13-0888	OV	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.6401
p.P78H	TCGA-18-3406	LUSC	TCGA	PPPY	ITCH	71:74	Mutation rewiring degron network	0.2222
p.P85S	TCGA-28-5213	GBM	TCGA	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.1944
p.P71Q	TCGA-44-2656	LUAD	TCGA	PPPY	ITCH	71:74	Mutation altering degron motif	0.7035
p.D64E	TCGA-55-8511	LUAD	TCGA	PPPY	ITCH	71:74	Mutation rewiring degron network	0.1389
p.A118S	TCGA-78-8662	LUAD	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.1389
p.Q102K	TCGA-86-8073	LUAD	TCGA	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.1944
p.A127D	TCGA-96-7545	LUSC	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.6682
p.S62L	TCGA-AG-3592	READ	TCGA	PPPY	ITCH	71:74	Mutation rewiring degron network	0.0833
p.S62L	TCGA-DK-A6AW	BLCA	TCGA	PPPY	ITCH	71:74	Mutation rewiring degron network	0.0833
p.D91N	TCGA-AJ-A3EK	UCEC	TCGA	NDPYSLNP	CBL_PTK	90:97	Mutation altering degron motif	0.5821
p.G107E	TCGA-B5-A0JY	UCEC	TCGA	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.0556
p.P130T	TCGA-BA-6868	HNSC	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.5919
p.R126Q	TCGA-CD-A4MG	STAD	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.7329
p.S116L	TCGA-D1-A16X	UCEC	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.0833
p.S116L	TCGA-EO-A22R	UCEC	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.0833
p.H88R	TCGA-D3-A8GM	SKCM	TCGA	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.2778
p.F70V	TCGA-DD-A4NV	LIHC	TCGA	PPPY	ITCH	71:74	Mutation rewiring degron network	0.3056
p.P73L	TCGA-EE-A2MI	SKCM	TCGA	PPPY	ITCH	71:74	Mutation altering degron motif	0.6471
p.P123L	TCGA-ER-A19F	SKCM	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.2778
p.H88Y	TCGA-ER-A19N	SKCM	TCGA	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.2778
p.P78L	TCGA-FR-A726	SKCM	TCGA	PPPY	ITCH	71:74	Mutation rewiring degron network	0.2222
p.P101H	TCGA-FS-A1ZZ	SKCM	TCGA	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.2222
p.P101H	SIDM00214	Colorectal Carcinoma	GDSC	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.2222
p.P101H	ACH-000955	Colon/Colorectal Cancer	CCLE	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.2222
p.P101H	SNU-407	large intestine	COSMIC	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.2222
p.P67L	TCGA-KK-A6E6	PRAD	TCGA	PPPY	ITCH	71:74	Mutation rewiring degron network	0.2222
p.P67L	SIDM01609	Endometrial Carcinoma	GDSC	PPPY	ITCH	71:74	Mutation rewiring degron network	0.2222
p.P67L	ACH-000972	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	71:74	Mutation rewiring degron network	0.2222
p.P105R	TCGA-L9-A5IP	LUAD	TCGA	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.1111
p.Y79D	TCGA-P5-A72U	LGG	TCGA	PPPY	ITCH	71:74	Mutation rewiring degron network	0.1944
p.G115D	TCGA-Y8-A895	KIRP	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.0556
p.S71L	DO48566	BLCA	ICGC	PPPY	ITCH	71:74	Mutation altering degron motif	0.7667
p.S71L	DO37308	READ	ICGC	PPPY	ITCH	71:74	Mutation altering degron motif	0.7667
p.S61L	DO49757	BLCA	ICGC	PPPY	ITCH	71:74	Mutation rewiring degron network	0.0556
p.S61L	DO222762	COCA	ICGC	PPPY	ITCH	71:74	Mutation rewiring degron network	0.0556
p.S61L	DO41020	UCEC	ICGC	PPPY	ITCH	71:74	Mutation rewiring degron network	0.0556
p.R120W	DO1297	BRCA	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation blocking phosphorylation signal	0.6389
p.A63T	DO8754	COAD	ICGC	PPPY	ITCH	71:74	Mutation rewiring degron network	0.1111
p.P85L	DO222842	COCA	ICGC	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.1944
p.S142L	DO234245	ESAD	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.0833
p.R135Q	DO234410	ESAD	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.2778
p.R135Q	DO48009	STAD	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.2778
p.V98I	DO223061	ESCA	ICGC	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.3056
p.S61A	DO233103	GACA	ICGC	PPPY	ITCH	71:74	Mutation rewiring degron network	0.0556
p.R120Q	DO233245	GACA	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation blocking phosphorylation signal	0.6389
p.R120Q	DO41935	UCEC	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation blocking phosphorylation signal	0.6389
p.R118W	DO233693	GACA	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.1389
p.P94S	DO13060	GBM	ICGC	NDPYSLNP	CBL_PTK	90:97	Mutation altering degron motif	0.6752
p.P139T	DO14184	HNSC	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.1667
p.G124D	DO49801	KIRP	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.3056
p.Y88D	DO219823	LGG	ICGC	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.2778
p.G124V	DO228952	LICA	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.3056
p.F79V	DO44876	LIHC	ICGC	PPPY	ITCH	71:74	Mutation rewiring degron network	0.1944
p.Y78C	DO48692	LIRI	ICGC	PPPY	ITCH	71:74	Mutation rewiring degron network	0.2222
p.S62C	DO23798	LUAD	ICGC	PPPY	ITCH	71:74	Mutation rewiring degron network	0.0833
p.A127S	DO45346	LUAD	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.6477
p.D73E	DO24940	LUAD	ICGC	PPPY	ITCH	71:74	Mutation altering degron motif	0.6758
p.P80Q	DO26052	LUAD	ICGC	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.0556
p.P80Q	DO26052	LUAD	ICGC	PPPY	ITCH	71:74	Mutation rewiring degron network	0.1667
p.P81R	DO230918	LUSC	ICGC	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.0833
p.P81R	DO230918	LUSC	ICGC	PPPY	ITCH	71:74	Mutation rewiring degron network	0.1389
p.P81R	DO224546	LUSC	ICGC	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.0833
p.P81R	DO224546	LUSC	ICGC	PPPY	ITCH	71:74	Mutation rewiring degron network	0.1389
p.A136D	DO26492	LUSC	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.25
p.P87H	DO26438	LUSC	ICGC	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.25
p.P94L	DO220884	MELA	ICGC	NDPYSLNP	CBL_PTK	90:97	Mutation altering degron motif	0.7582
p.P139R	DO30420	OV	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.1667
p.P64L	DO229580	PRAD	ICGC	PPPY	ITCH	71:74	Mutation rewiring degron network	0.1389
p.P64L	DO41871	UCEC	ICGC	PPPY	ITCH	71:74	Mutation rewiring degron network	0.1389
p.P76L	DO51361	PRAD	ICGC	PPPY	ITCH	71:74	Mutation rewiring degron network	0.2778
p.P132L	DO37679	SKCM	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.7582
p.P82L	DO37531	SKCM	ICGC	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.1111
p.P82L	DO37531	SKCM	ICGC	PPPY	ITCH	71:74	Mutation rewiring degron network	0.1111
p.H97Y	DO37452	SKCM	ICGC	NDPYSLNP	CBL_PTK	90:97	Mutation altering degron motif	0.7229
p.H97R	DO50288	SKCM	ICGC	NDPYSLNP	CBL_PTK	90:97	Mutation altering degron motif	0.8244
p.P87L	DO48665	SKCM	ICGC	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.25
p.A63V	DO38663	STAD	ICGC	PPPY	ITCH	71:74	Mutation rewiring degron network	0.1111
p.G116E	DO43041	UCEC	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.0833
p.D100N	DO41584	UCEC	ICGC	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.25
p.S125L	DO41799	UCEC	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.7667
p.S125L	DO42713	UCEC	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.7667
p.D136H	SIDM00857	Melanoma	GDSC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.25
p.D136H	ACH-000572	Skin Cancer	CCLE	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation rewiring degron network	0.25
p.A128S	SIDM01099	Neuroblastoma	GDSC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.6477
p.A128S	ACH-000341	Neuroblastoma	CCLE	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.6477
p.H80Q	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.0556
p.H80Q	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	71:74	Mutation rewiring degron network	0.1667
p.H80Q	ACH-000851	Lung Cancer	CCLE	NDPYSLNP	CBL_PTK	90:97	Mutation rewiring degron network	0.0556
p.H80Q	ACH-000851	Lung Cancer	CCLE	PPPY	ITCH	71:74	Mutation rewiring degron network	0.1667
p.A128T	SIDM01619	Endometrial Carcinoma	GDSC	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.6028
p.A128T	ACH-000984	Endometrial/Uterine Cancer	CCLE	PRAALPQLS	DEG_APCC_DBOX_1	125:133	Mutation altering degron motif	0.6028

Kaplan plot for TFAP2B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TFAP2B

UniProt ID: Q92481

Entrez ID: 7021

Protein name: Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TFAP2B in