DegronMD

Uniprot ID: Q92481

Source protein: Transcription factor AP-2-beta

Source gene: TFAP2B

Class: DEG_APCC_DBOX_1

Location: 125:133

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9964

ASA_SCORE: 72.5

COIL: 0.7921

CONS_SCORE: 0.4692

DSS_SCORE: 0.6128

HELIX: 0.1332

FCONS_SCORE: 1.0641

RIG_SCORE: 0.674

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S125L	DO41799	UCEC	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.7667
p.S125L	DO42713	UCEC	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.7667
p.P132L	DO37679	SKCM	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.7582
p.R126Q	TCGA-CD-A4MG	STAD	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	0.7329
p.A127D	TCGA-96-7545	LUSC	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	0.6682
p.A127S	DO45346	LUAD	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.6477
p.A128S	SIDM01099	Neuroblastoma	GDSC	PRAALPQLS	DEG_APCC_DBOX_1	0.6477
p.A128S	ACH-000341	Neuroblastoma	CCLE	PRAALPQLS	DEG_APCC_DBOX_1	0.6477
p.P130R	TCGA-13-0888	OV	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	0.6401
p.R120W	DO1297	BRCA	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.6389
p.R120Q	DO233245	GACA	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.6389
p.R120Q	DO41935	UCEC	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.6389
p.A128T	SIDM01619	Endometrial Carcinoma	GDSC	PRAALPQLS	DEG_APCC_DBOX_1	0.6028
p.A128T	ACH-000984	Endometrial/Uterine Cancer	CCLE	PRAALPQLS	DEG_APCC_DBOX_1	0.6028
p.P130T	TCGA-BA-6868	HNSC	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	0.5919
p.G124D	DO49801	KIRP	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.3056
p.G124V	DO228952	LICA	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.3056
p.P123L	TCGA-ER-A19F	SKCM	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	0.2778
p.R135Q	DO234410	ESAD	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.2778
p.R135Q	DO48009	STAD	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.2778
p.A136D	DO26492	LUSC	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.25
p.D136H	SIDM00857	Melanoma	GDSC	PRAALPQLS	DEG_APCC_DBOX_1	0.25
p.D136H	ACH-000572	Skin Cancer	CCLE	PRAALPQLS	DEG_APCC_DBOX_1	0.25
p.P139T	DO14184	HNSC	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.1667
p.P139R	DO30420	OV	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92481	Transcription factor AP-2-beta	DEG_APCC_DBOX_1	125:133	PRAALPQLS	APC,CDC20,FZR1	0.9964	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons