DegronMD

Uniprot ID: Q92481

Source protein: Transcription factor AP-2-beta

Source gene: TFAP2B

Class: DEG_APCC_DBOX_1

Location: 125:133

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9964

ASA_SCORE: 72.5

COIL: 0.7921

CONS_SCORE: 0.4692

DSS_SCORE: 0.6128

HELIX: 0.1332

FCONS_SCORE: 1.0641

RIG_SCORE: 0.674

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P130R	TCGA-13-0888	OV	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	0.6401
p.A118S	TCGA-78-8662	LUAD	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	0.1389
p.A127D	TCGA-96-7545	LUSC	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	0.6682
p.P130T	TCGA-BA-6868	HNSC	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	0.5919
p.R126Q	TCGA-CD-A4MG	STAD	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	0.7329
p.S116L	TCGA-D1-A16X	UCEC	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	0.0833
p.S116L	TCGA-EO-A22R	UCEC	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	0.0833
p.P123L	TCGA-ER-A19F	SKCM	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	0.2778
p.G115D	TCGA-Y8-A895	KIRP	TCGA	PRAALPQLS	DEG_APCC_DBOX_1	0.0556
p.R120W	DO1297	BRCA	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.6389
p.S142L	DO234245	ESAD	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.0833
p.R135Q	DO234410	ESAD	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.2778
p.R135Q	DO48009	STAD	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.2778
p.R120Q	DO233245	GACA	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.6389
p.R120Q	DO41935	UCEC	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.6389
p.R118W	DO233693	GACA	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.1389
p.P139T	DO14184	HNSC	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.1667
p.G124D	DO49801	KIRP	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.3056
p.G124V	DO228952	LICA	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.3056
p.A127S	DO45346	LUAD	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.6477
p.A136D	DO26492	LUSC	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.25
p.P139R	DO30420	OV	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.1667
p.P132L	DO37679	SKCM	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.7582
p.G116E	DO43041	UCEC	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.0833
p.S125L	DO41799	UCEC	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.7667
p.S125L	DO42713	UCEC	ICGC	PRAALPQLS	DEG_APCC_DBOX_1	0.7667
p.D136H	SIDM00857	Melanoma	GDSC	PRAALPQLS	DEG_APCC_DBOX_1	0.25
p.D136H	ACH-000572	Skin Cancer	CCLE	PRAALPQLS	DEG_APCC_DBOX_1	0.25
p.A128S	SIDM01099	Neuroblastoma	GDSC	PRAALPQLS	DEG_APCC_DBOX_1	0.6477
p.A128S	ACH-000341	Neuroblastoma	CCLE	PRAALPQLS	DEG_APCC_DBOX_1	0.6477
p.A128T	SIDM01619	Endometrial Carcinoma	GDSC	PRAALPQLS	DEG_APCC_DBOX_1	0.6028
p.A128T	ACH-000984	Endometrial/Uterine Cancer	CCLE	PRAALPQLS	DEG_APCC_DBOX_1	0.6028

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRAALPQLS

Degron related mutations and impact score

Drug responses associated with TFAP2B mutations

All proteins holding degron of PRAALPQLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92481	Transcription factor AP-2-beta	DEG_APCC_DBOX_1	125:133	PRAALPQLS	APC,CDC20,FZR1	0.9964	More...