DegronMD

Uniprot ID: Q92481

Source protein: Transcription factor AP-2-beta

Source gene: TFAP2B

Class: CBL_PTK

Location: 90:97

E3 ligase: CBL

DEGRON score: 0.9433

ASA_SCORE: 55.125

COIL: 0.8641

CONS_SCORE: 0.4701

DSS_SCORE: 0.7143

HELIX: 0.0795

FCONS_SCORE: 1.0158

RIG_SCORE: 0.6439

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P85S	TCGA-28-5213	GBM	TCGA	NDPYSLNP	CBL_PTK	0.1944
p.Q102K	TCGA-86-8073	LUAD	TCGA	NDPYSLNP	CBL_PTK	0.1944
p.D91N	TCGA-AJ-A3EK	UCEC	TCGA	NDPYSLNP	CBL_PTK	0.5821
p.G107E	TCGA-B5-A0JY	UCEC	TCGA	NDPYSLNP	CBL_PTK	0.0556
p.H88R	TCGA-D3-A8GM	SKCM	TCGA	NDPYSLNP	CBL_PTK	0.2778
p.H88Y	TCGA-ER-A19N	SKCM	TCGA	NDPYSLNP	CBL_PTK	0.2778
p.P101H	TCGA-FS-A1ZZ	SKCM	TCGA	NDPYSLNP	CBL_PTK	0.2222
p.P101H	SIDM00214	Colorectal Carcinoma	GDSC	NDPYSLNP	CBL_PTK	0.2222
p.P101H	ACH-000955	Colon/Colorectal Cancer	CCLE	NDPYSLNP	CBL_PTK	0.2222
p.P101H	SNU-407	large_intestine	COSMIC	NDPYSLNP	CBL_PTK	0.2222
p.P105R	TCGA-L9-A5IP	LUAD	TCGA	NDPYSLNP	CBL_PTK	0.1111
p.P85L	DO222842	COCA	ICGC	NDPYSLNP	CBL_PTK	0.1944
p.V98I	DO223061	ESCA	ICGC	NDPYSLNP	CBL_PTK	0.3056
p.P94S	DO13060	GBM	ICGC	NDPYSLNP	CBL_PTK	0.6752
p.Y88D	DO219823	LGG	ICGC	NDPYSLNP	CBL_PTK	0.2778
p.P80Q	DO26052	LUAD	ICGC	NDPYSLNP	CBL_PTK	0.0556
p.P81R	DO230918	LUSC	ICGC	NDPYSLNP	CBL_PTK	0.0833
p.P81R	DO224546	LUSC	ICGC	NDPYSLNP	CBL_PTK	0.0833
p.P87H	DO26438	LUSC	ICGC	NDPYSLNP	CBL_PTK	0.25
p.P94L	DO220884	MELA	ICGC	NDPYSLNP	CBL_PTK	0.7582
p.P82L	DO37531	SKCM	ICGC	NDPYSLNP	CBL_PTK	0.1111
p.H97Y	DO37452	SKCM	ICGC	NDPYSLNP	CBL_PTK	0.7229
p.H97R	DO50288	SKCM	ICGC	NDPYSLNP	CBL_PTK	0.8244
p.P87L	DO48665	SKCM	ICGC	NDPYSLNP	CBL_PTK	0.25
p.D100N	DO41584	UCEC	ICGC	NDPYSLNP	CBL_PTK	0.25
p.H80Q	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	NDPYSLNP	CBL_PTK	0.0556
p.H80Q	ACH-000851	Lung Cancer	CCLE	NDPYSLNP	CBL_PTK	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05549	Transcription factor AP-2-alpha	CBL_PTK	77:84	NDPYSLNP	CBL	0.9656	More...
Q92481	Transcription factor AP-2-beta	CBL_PTK	90:97	NDPYSLNP	CBL	0.9433	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons