DegronMD - P05549(TFAP2A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D71Y	TCGA-06-5416	GBM	TCGA	NDPYSLNP	CBL_PTK	77:84	Mutation rewiring degron network	0.1667
p.D71Y	TCGA-06-5416	GBM	TCGA	PPPY	ITCH	59:62	Mutation rewiring degron network	0.0833
p.S74F	TCGA-06-6694	GBM	TCGA	NDPYSLNP	CBL_PTK	77:84	Mutation rewiring degron network	0.25
p.S69W	TCGA-94-8491	LUSC	TCGA	NDPYSLNP	CBL_PTK	77:84	Mutation rewiring degron network	0.1111
p.S69W	TCGA-94-8491	LUSC	TCGA	PPPY	ITCH	59:62	Mutation rewiring degron network	0.1389
p.P55S	TCGA-96-A4JK	LUSC	TCGA	PPPY	ITCH	59:62	Mutation rewiring degron network	0.2222
p.Q88E	TCGA-A2-A1G0	BRCA	TCGA	NDPYSLNP	CBL_PTK	77:84	Mutation rewiring degron network	0.2222
p.V76I	TCGA-AX-A0J0	UCEC	TCGA	NDPYSLNP	CBL_PTK	77:84	Mutation rewiring degron network	0.3056
p.N77S	TCGA-AX-A0J1	UCEC	TCGA	NDPYSLNP	CBL_PTK	77:84	Mutation altering degron motif	0.7069
p.P49H	TCGA-EE-A2M8	SKCM	TCGA	PPPY	ITCH	59:62	Mutation rewiring degron network	0.0556
p.P72L	TCGA-GV-A3QF	BLCA	TCGA	NDPYSLNP	CBL_PTK	77:84	Mutation rewiring degron network	0.1944
p.P72L	TCGA-GV-A3QF	BLCA	TCGA	PPPY	ITCH	59:62	Mutation rewiring degron network	0.0556
p.D78N	TCGA-MA-AA3Y	CESC	TCGA	NDPYSLNP	CBL_PTK	77:84	Mutation altering degron motif	0.5821
p.P59S	TCGA-MT-A67F	HNSC	TCGA	PPPY	ITCH	59:62	Mutation altering degron motif	0.6752
p.P84L	TCGA-RP-A694	SKCM	TCGA	NDPYSLNP	CBL_PTK	77:84	Mutation altering degron motif	0.7582
p.P66L	DO471	BLCA	ICGC	PPPY	ITCH	59:62	Mutation rewiring degron network	0.2222
p.Q82E	DO5920	BRCA	ICGC	NDPYSLNP	CBL_PTK	77:84	Mutation altering degron motif	0.6744
p.D72N	DO219721	CESC	ICGC	NDPYSLNP	CBL_PTK	77:84	Mutation rewiring degron network	0.1944
p.D72N	DO219721	CESC	ICGC	PPPY	ITCH	59:62	Mutation rewiring degron network	0.0556
p.P85L	DO230346	COCA	ICGC	NDPYSLNP	CBL_PTK	77:84	Mutation rewiring degron network	0.3056
p.S68F	DO11052	GBM	ICGC	NDPYSLNP	CBL_PTK	77:84	Mutation rewiring degron network	0.0833
p.S68F	DO11052	GBM	ICGC	PPPY	ITCH	59:62	Mutation rewiring degron network	0.1667
p.D65Y	DO10880	GBM	ICGC	PPPY	ITCH	59:62	Mutation rewiring degron network	0.25
p.P53S	DO49070	HNSC	ICGC	PPPY	ITCH	59:62	Mutation rewiring degron network	0.1667
p.P83Q	DO228952	LICA	ICGC	NDPYSLNP	CBL_PTK	77:84	Mutation altering degron motif	0.7035
p.H80Q	DO228974	LICA	ICGC	NDPYSLNP	CBL_PTK	77:84	Mutation altering degron motif	0.7582
p.P49S	DO45442	LUSC	ICGC	PPPY	ITCH	59:62	Mutation rewiring degron network	0.0556
p.S63W	DO219174	LUSC	ICGC	PPPY	ITCH	59:62	Mutation rewiring degron network	0.3056
p.P78L	DO51269	SKCM	ICGC	NDPYSLNP	CBL_PTK	77:84	Mutation altering degron motif	0.7582
p.F52S	DO229253	THCA	ICGC	PPPY	ITCH	59:62	Mutation rewiring degron network	0.1389
p.H69Q	DO229264	THCA	ICGC	NDPYSLNP	CBL_PTK	77:84	Mutation rewiring degron network	0.1111
p.H69Q	DO229264	THCA	ICGC	PPPY	ITCH	59:62	Mutation rewiring degron network	0.1389
p.N71S	DO41199	UCEC	ICGC	NDPYSLNP	CBL_PTK	77:84	Mutation rewiring degron network	0.1667
p.N71S	DO41199	UCEC	ICGC	PPPY	ITCH	59:62	Mutation rewiring degron network	0.0833
p.V70I	DO41133	UCEC	ICGC	NDPYSLNP	CBL_PTK	77:84	Mutation rewiring degron network	0.1389
p.V70I	DO41133	UCEC	ICGC	PPPY	ITCH	59:62	Mutation rewiring degron network	0.1111
p.P64S	SIDM02061	Esophageal Carcinoma	GDSC	PPPY	ITCH	59:62	Mutation rewiring degron network	0.2778
p.P89S	SIDM02059	Colorectal Carcinoma	GDSC	NDPYSLNP	CBL_PTK	77:84	Mutation rewiring degron network	0.1944
p.N50H	SIDM00296	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	59:62	Mutation rewiring degron network	0.0833
p.A87T	ACH-000985	Colon/Colorectal Cancer	CCLE	NDPYSLNP	CBL_PTK	77:84	Mutation rewiring degron network	0.25
p.Y80C	ACH-000998	Colon/Colorectal Cancer	CCLE	NDPYSLNP	CBL_PTK	77:84	Mutation altering degron motif	0.7087

Kaplan plot for TFAP2A in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TFAP2A

UniProt ID: P05549

Entrez ID: 7020

Protein name: Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TFAP2A in