DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NDPYSLNP
Uniprot ID:
P05549
Source protein:
Transcription factor AP-2-alpha
Source gene:
TFAP2A
Class:
CBL_PTK
Location:
77:84
E3 ligase:
CBL
DEGRON score:
0.9656
ASA_SCORE:
60.7375
COIL:
0.8038
CONS_SCORE:
0.4444
DSS_SCORE:
0.7138
HELIX:
0.1291
FCONS_SCORE:
1.0548
RIG_SCORE:
0.6429
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D71Y
TCGA-06-5416
GBM
TCGA
NDPYSLNP
CBL_PTK
0.1667
p.S74F
TCGA-06-6694
GBM
TCGA
NDPYSLNP
CBL_PTK
0.25
p.S69W
TCGA-94-8491
LUSC
TCGA
NDPYSLNP
CBL_PTK
0.1111
p.Q88E
TCGA-A2-A1G0
BRCA
TCGA
NDPYSLNP
CBL_PTK
0.2222
p.V76I
TCGA-AX-A0J0
UCEC
TCGA
NDPYSLNP
CBL_PTK
0.3056
p.N77S
TCGA-AX-A0J1
UCEC
TCGA
NDPYSLNP
CBL_PTK
0.7069
p.P72L
TCGA-GV-A3QF
BLCA
TCGA
NDPYSLNP
CBL_PTK
0.1944
p.D78N
TCGA-MA-AA3Y
CESC
TCGA
NDPYSLNP
CBL_PTK
0.5821
p.P84L
TCGA-RP-A694
SKCM
TCGA
NDPYSLNP
CBL_PTK
0.7582
p.Q82E
DO5920
BRCA
ICGC
NDPYSLNP
CBL_PTK
0.6744
p.D72N
DO219721
CESC
ICGC
NDPYSLNP
CBL_PTK
0.1944
p.P85L
DO230346
COCA
ICGC
NDPYSLNP
CBL_PTK
0.3056
p.S68F
DO11052
GBM
ICGC
NDPYSLNP
CBL_PTK
0.0833
p.P83Q
DO228952
LICA
ICGC
NDPYSLNP
CBL_PTK
0.7035
p.H80Q
DO228974
LICA
ICGC
NDPYSLNP
CBL_PTK
0.7582
p.P78L
DO51269
SKCM
ICGC
NDPYSLNP
CBL_PTK
0.7582
p.H69Q
DO229264
THCA
ICGC
NDPYSLNP
CBL_PTK
0.1111
p.N71S
DO41199
UCEC
ICGC
NDPYSLNP
CBL_PTK
0.1667
p.V70I
DO41133
UCEC
ICGC
NDPYSLNP
CBL_PTK
0.1389
p.P89S
SIDM02059
Colorectal Carcinoma
GDSC
NDPYSLNP
CBL_PTK
0.1944
p.A87T
ACH-000985
Colon/Colorectal Cancer
CCLE
NDPYSLNP
CBL_PTK
0.25
p.Y80C
ACH-000998
Colon/Colorectal Cancer
CCLE
NDPYSLNP
CBL_PTK
0.7087
Drug responses associated with TFAP2A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NDPYSLNP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P05549
Transcription factor AP-2-alpha
CBL_PTK
77:84
NDPYSLNP
CBL
0.9656
More...
Q92481
Transcription factor AP-2-beta
CBL_PTK
90:97
NDPYSLNP
CBL
0.9433
More...