DegronMD - Q969F2(NKD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H408Y	TCGA-CK-4951	COAD	TCGA	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation rewiring degron network	0.1667
p.T417M	DO50451	ESAD	ICGC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation altering degron motif	0.7423
p.T417M	DO233920	GACA	ICGC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation altering degron motif	0.7423
p.T417M	SIDM01265	Plasma Cell Myeloma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation altering degron motif	0.7423
p.T417M	SIDM01126	Small Cell Lung Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation altering degron motif	0.7423
p.T417M	SIDM00721	Small Cell Lung Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation altering degron motif	0.7423
p.T417M	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation altering degron motif	0.7423
p.R430Q	DO234357	ESAD	ICGC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation rewiring degron network	0.0833
p.P377L	DO218068	GACA	ICGC	PPPY	ITCH	377:380	Mutation altering degron motif	0.7582
p.A424V	DO233899	GACA	ICGC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation rewiring degron network	0.25
p.P415L	DO228176	PBCA	ICGC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation altering degron motif	0.6471
p.P415L	SIDM00267	Biliary Tract Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation altering degron motif	0.6471
p.P415L	SIDM00296	Small Cell Lung Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation altering degron motif	0.6471
p.P415L	SIDM00589	Oral Cavity Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation altering degron motif	0.6471
p.P415L	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation altering degron motif	0.6471
p.P415L	SIDM00301	Pancreatic Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation altering degron motif	0.6471
p.P415L	SIDM00687	Gastric Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation altering degron motif	0.6471
p.P415L	SIDM01735	Biliary Tract Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation altering degron motif	0.6471
p.P415L	SIDM01494	Glioblastoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation altering degron motif	0.6471
p.R412Q	SIDM01293	Colorectal Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation rewiring degron network	0.2778
p.R430W	SIDM00631	Breast Carcinoma	GDSC	LPPTPAGE	DEG_SCF_FBW7_2	414:421	Mutation rewiring degron network	0.0833
p.P378L	SIDM00893	Breast Carcinoma	GDSC	PPPY	ITCH	377:380	Mutation altering degron motif	0.7582
p.P378L	ACH-000536	Breast Cancer	CCLE	PPPY	ITCH	377:380	Mutation altering degron motif	0.7582
p.R384Q	SIDM00312	Plasma Cell Myeloma	GDSC	PPPY	ITCH	377:380	Mutation rewiring degron network	0.2222
p.Q374K	ACH-000888	Lung Cancer	CCLE	PPPY	ITCH	377:380	Mutation rewiring degron network	0.25
p.H382Y	ACH-000931	Skin Cancer	CCLE	PPPY	ITCH	377:380	Mutation rewiring degron network	0.2778

Kaplan plot for NKD2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NKD2

UniProt ID: Q969F2

Entrez ID: 85409

Protein name: Protein naked cuticle homolog 2 (Naked-2) (hNkd2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NKD2 in